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リンク元 | 「慢性拒絶反応」 |
関連記事 | 「反応」「拒否」「慢性」 |
hyperacute rejection | Antibody mediated due to the presence of preformed antidonor antibodies in the transplant recipient.
Occurs within minutes after transplantation. |
acute rejection | Cell mediated due to cytotoxic T lymphocytes reacting against foreign MHCs.
Occurs weeks after transplantation. Reversible with immunosuppressants such as cyclosporin and OKT3. |
chronic rejection | Antibody-mediated vascular damage (fibrinoid necrosis);
Occurs months to years after transplantation. Irreversible. |
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