出典: meddic

FcγRIII低親和性Fcγ受容体 lowaffinity Fcγ receptor
  • FcγRIII
  • NK細胞の抗体依存性細胞介在性細胞傷害(ADCC)に重要



  • Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity ADCC

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/14 04:47:10」(JST)

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  • Monocytes as a diagnostic marker of cardiovascular diseases.
  • Gratchev A, Sobenin I, Orekhov A, Kzhyshkowska J.SourceDepartment of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany; Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Russia.
  • Immunobiology.Immunobiology.2012 May;217(5):476-82. Epub 2012 Jan 13.
  • Inflammation is an important pathogenic factor of cardiovascular diseases. Inflammatory processes induce the organism systemic changes that are sensed by the cells of innate immune system. These systemic changes include increased concentrations of soluble factors capable of activating monocytes in t
  • PMID 22325375
  • Aberrant expression of FcγRIIIA (CD16) contributes to the development of atherosclerosis.
  • Huang Y, Yin H, Wang J, Liu Q, Wu C, Chen K.AbstractPrevious studies have documented that Fc receptor III A of immunoglobulin G (FcγRIIIA, also named CD16) is involved in the development of coronary heart disease (CHD). However, the mechanism responsible for FcγRIIIA's in contribution to CHD development remains largely unclear. Herein, we investigated the possible role of FcγRIIIA in the development of atherosclerosis. Our results showed that the elevated level of FcγRIIIA on monocytes closely correlated to the adhesive efficiency of human umbilical vein endothelial cells (HUVECs) in vitro. Importantly, we also observed increased population of CD16(+) monocytes and elevated CD16 level on monocytes in ApoE(-/-) mice with characterized atherosclerosis after feeding with high-fat diet for 10weeks. The enhancement of CD16 on monocytes closely correlated to increased content of MMP-9 in aorta and increased inflammatory cytokines in sera. In addition, similar to simvastatin, recombinant human M-CSF represented a robust inhibitory influence on plaque instability and inflammation. Taken together, these data established that FcγRIIIA (CD16)-mediated signaling orchestrated by interaction between monocytes and HUVECs, coupled with inflammatory cytokine stimulation and MMP activation, as a fundamental pathway linked to the development of atherosclerotic formation. Inhibition of FcγRIIIA or its signaling thus might represent a promising approach for the prevention and treatment of CHD.
  • Gene.Gene.2012 Apr 25;498(1):91-5. Epub 2012 Feb 15.
  • Previous studies have documented that Fc receptor III A of immunoglobulin G (FcγRIIIA, also named CD16) is involved in the development of coronary heart disease (CHD). However, the mechanism responsible for FcγRIIIA's in contribution to CHD development remains largely unclear. Herein, we investiga
  • PMID 22366371
  • Methods to measure the binding of therapeutic monoclonal antibodies to the human Fc receptor FcγRIII (CD16) using real time kinetic analysis and flow cytometry.
  • Harrison A, Liu Z, Makweche S, Maskell K, Qi H, Hale G.SourceMillipore BioPharma Services, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Apr 7;63:23-8. Epub 2012 Jan 30.
  • Two different methods have been developed to measure the binding of therapeutic antibodies to the low affinity human Fc receptor FcγRIII (CD16). The first measures binding of antibody to recombinant soluble receptor by surface plasmon resonance and the second uses flow cytometry to measure antibody
  • PMID 22366323


  • CD16(+) natural killer cells play a limited role against primary dengue virus infection in tamarins.
  • Yoshida Tomoyuki,Omatsu Tsutomu,Saito Akatsuki,Katakai Yuko,Iwasaki Yuki,Iijima Sayuki,Kurosawa Terue,Hamano Masataka,Nakamura Shinichiro,Takasaki Tomohiko,Yasutomi Yasuhiro,Kurane Ichiro,Akari Hirofumi
  • Archives of virology 157(2), 363-368, 2012-02
  • CD16 is a major molecule expressed on NK cells. … To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo, CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. … This resulted in the transient depletion of CD16(+) NK cells, whereas no significant effects on the overall levels or kinetics of plasma viral loads and antiviral antibodies were observed in the treated monkeys when compared to control monkeys. …
  • NAID 120003874271
  • 4)免疫学的異常による流産原因の解明(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)
  • 中島 彰俊
  • 日本産科婦人科學會雜誌 63(12), 2185-2197, 2011-12-01
  • … Results: First topic is the cytokines expression profiles of CD16^-CD56^<bright> … Second is the direct correlation between extravillous trophoblasts (EVTs) and CD16^-CD56^<bright> …
  • NAID 110008799037
  • 3)免疫機構から見た流産の病態解明とその対策(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)
  • 福井 淳史
  • 日本産科婦人科學會雜誌 63(12), 2167-2184, 2011-12-01
  • … The main population of uterine NK cell is CD16^-/CD56^<bright> … cytokine producing cells and that of peripheral blood NK cell is CD16^+/CD56^<dim> … We reported that the percentages of CD16^+/CD56^<dim> … NK cells in peripheral blood and the endometrium were significantly higher while that of CD16^-/CD56^<btight> … After treatment with Danazol, endometrial CD16^-/CD56^<bright> …
  • NAID 110008799036


CD16 【FcγRⅢ】 CD16はIgGの低親和性レセプタ(FcγRⅢ)で、FcγRⅢA(またはⅢ-2)とFcγRⅢB(またはⅢ-1)の2種類の遺伝子でコードされているアイソフォームがあります。このCD16遺伝子多型により異なる膜タンパクが ...
製品&受託サービス MACS 細胞解析 抗体・試薬 MACS 抗体 ... 細胞分離 細胞解析 細胞培養 分子生物学的アプリケーション イメージング 腫瘍血管新生 サンプル調製 細胞分離 細胞解析
備考 曜日指定 受託可能日は月~金曜日です。10項目以上依頼の場合は血液5.0mL採血してください。主として反応する細胞・代表的な反応性:NK細胞(Fcγレセプター) 曜日指定 受託可能日は月~金曜日です。検体取扱方法


SPEEDSTER 50 (CD16)Lettore CDCD16Human CD16Istanbul Mehmet Traditional CD16activation of NK cells, promote CD16 Leonardo CD16Cd16 Cd16




lymphocyte (Z)
リンパ細胞免疫細胞 immunocytes

  • 白血球の一種で、無顆粒球に分類される。
  • 末梢血に白血球が4000-9000 /μl存在するとすれば、リンパ球の存在比は26-46.6 %といわれているので、リンパ球は1040-4194 /μl存在。(IMD)


細胞膜上に発現しているリガンド? (2007前期生理学授業プリント)

    αβTCR TCR Ig CD3 CD4 CD8 CD16 CD56
T細胞 ○             


  • リンパ球数は生後1ヶ月以降に増加して6ヶ月~1年でピークとなり、以降減少して成人と同程度となる。
  • これに対して好中球は生下時にピークとなり、以降減少して成人と同程度となる。
  • 生後一ヶ月までは好中球優位であり、1ヶ月~2-6歳まではリンパ球優位となり、以降好中球優位となる。



natural killer cell, NK cell
単球自然免疫LAK細胞ナチュラルキラー細胞活性natural killer


  • 自然免疫
  • リンパ球の5-10%を占めるらしい。
Large granular lymphocytes(LGLs) or NK cells account for 5-10% of periphral blood plymphocytes.(HAR.2024)
  • 大型のアズール好性顆粒を有する(SMB.41)
  • 単球と共に自然免疫に関与
  • ウイルス感染細胞やガン細胞を傷害する細胞で、T細胞に特異的なマーカをもたずに直接標的細胞を攻撃する (人間の正常構造と機能 VIIA血管・免疫 p.29)
  • 抗体依存性細胞毒性(ADCC)





  • IgGのFc部を結合し、顆粒を放出する(IMM.96)


  • CD16:IgGのFc部に対するレセプター
  • CD56:NCAM-I
  • NK1.1(NKRP-1 = CD161)


  • CD8:IL-2に反応してNK細胞が増殖
  • CD57:多くの細胞表面で発現


リガンド 作用 産生
IL-12 NK細胞活性化 INF-γ
IL-18 Th1分化促進
  • IL-12,IL-18により活性化され、IFN-γを産生
  • IL-2により活性化し、細胞障害能が高まる (SPU.65)


  • NIR
MHC class Iを認識して攻撃を抑制。MHC class Iが少ないと抑制が外れる(IMM.96)



[show details]

食細胞表面レセプター (SMB.38)

リガンド種 受容体 CD リガンド 発現
抗体 FcγRI CD64 IgG3, IgG1, IgG4 マクロファージ
FcγRII CD32 IgG3, IgG1, IgG2 多核白血球
FcγRIII CD16 IgG1, IgG3  
補体 CR1 CD35 C3b  
CR3 CD11b/CD18 iC3b  
CR4 CD11c/CD18 iC3b  



cluster of differentiation, CD
  • 細胞の表面抗原を認識する抗体を整理した分類
Bリンパ球 CD10,CD19,CD20
Tリンパ球 CD2,CD3,CD5,CD7
幹細胞 CD34
顆粒球 CD13,CD33
単球 CD14:LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
巨核球 CD41(GpIIb),CD42(GpIb)

CD1 CD21 CD41 CD61 CD81
CD2 CD22 CD42 CD62 CD82
CD3 CD23 CD43 CD63 CD83
CD4 CD24 CD44 CD64 CD84
CD5 CD25 CD45 CD65 CD85
CD6 CD26 CD46 CD66 CD86
CD7 CD27 CD47 CD67 CD87
CD8 CD28 CD48 CD68 CD88
CD9 CD29 CD49 CD69 CD89
CD10 CD30 CD50 CD70 CD90
CD11 CD31 CD51 CD71 CD91
CD12 CD32 CD52 CD72 CD92
CD13 CD33 CD53 CD73 CD93
CD14 CD34 CD54 CD74 CD94
CD15 CD35 CD55 CD75 CD95
CD16 CD36 CD56 CD76 CD96
CD17 CD37 CD57 CD77 CD97
CD18 CD38 CD58 CD78 CD98
CD19 CD39 CD59 CD79 CD99
CD20 CD40 CD60 CD80 CD100



lymphokine activated killer cell, LAK cell
リンホカイン活性化キラー細胞 lymphokine-activated killer cell



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