同: Ecto-5'-nucleotidase, Lymphocyte vas- cular adhesion protein-2

PrepTutorEJDIC

certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/30 23:53:17」(JST)

wiki en

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (Cluster of Differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.^[1] CD73 commonly serves to convert AMP to adenosine.

Function

Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.^[2] Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.^[3]^[4]^[5]

References

^ Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". Eur. J. Biochem. 191 (3): 563–9. doi:10.1111/j.1432-1033.1990.tb19158.x. PMID 2129526.
^ "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)".
^ St. Hilaire, Cynthia; Ziegler, Shira G.; Markello, Thomas C.; Brusco, Alfredo; Groden, Catherine; Gill, Fred; Carlson-Donohoe, Hannah; Lederman, Robert J.; Chen, Marcus Y.; Yang, Dan; Siegenthaler, Michael P.; Arduino, Carlo; Mancini, Cecilia; Freudenthal, Bernard; Stanescu, Horia C.; Zdebik, Anselm A.; Chaganti, R. Krishna; Nussbaum, Robert L.; Kleta, Robert; Gahl, William A.; Boehm, Manfred (2011). "NT5EMutations and Arterial Calcifications". New England Journal of Medicine 364 (5): 432–442. doi:10.1056/NEJMoa0912923. ISSN 0028-4793.
^ Sharp, J. (March 1954). "Heredo-familial vascular and articular calcification". Ann. Rheum. Dis. 13 (1): 15–27. doi:10.1136/ard.13.1.15. PMC 1030367. PMID 13149051.
^ Online 'Mendelian Inheritance in Man' (OMIM) 211800

External links

NT5E protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 慢性腎疾患における血管石灰化の生物学 biology of vascular calcification in chronic kidney disease
2. 新生児の免疫 immunity of the newborn

English Journal

Impaired ATP-Induced Coronary Blood Flow and Diminished Aortic NTPDase Activity Precede Lesion Formation in Apolipoprotein E-Deficient Mice.

Mercier N, Kiviniemi TO, Saraste A, Miiluniemi M, Silvola J, Jalkanen S, Yegutkin GG.SourceMedicity Research Laboratory and the Department of Medical Microbiology, University of Turku, Turku, Finland.
The American journal of pathology.Am J Pathol.2012 Jan;180(1):419-28. Epub 2011 Nov 7.
Intravascular ATP and ADP are important regulators of vascular tone, thrombosis, inflammation, and angiogenesis. This study was undertaken to evaluate the contribution of purinergic signaling to disturbed vasodilation and vascular remodeling during atherosclerosis progression. We used apolipoprotein
PMID 22074736

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

Garavaglia S, Bruzzone S, Cassani C, Canella L, Allegrone G, Sturla L, Mannino E, Millo E, De Flora A, Rizzi M.Source*Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, University of Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100 Novara, Italy.
The Biochemical journal.Biochem J.2012 Jan 1;441(1):131-41.
Haemophilus influenzae is a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NAD(P) for its nicotinamide dinucleotide requirement. This strategy is organized around a periplasmic enzyme termed NadN (NAD nucleotidase), which plays a central role by d
PMID 21933152

Japanese Journal

Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells

KIM Beom-Su,KIM Yoon-Chul,ZADEH Homa,PARK Yoon-Jeong,PI Sung-Hee,SHIN Hyung-Shik,YOU Hyung-Keun
Bioscience, Biotechnology, and Biochemistry 75(1), 13-19, 2011
… They showed a fibroblast-like morphology and expressed CD29, CD44, CD73, and CD105, but not CD34. …
NAID 130000406528

RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells

ZHI Xiuling,WANG Yingjian,ZHOU Xuerui,YU Jerry,JIAN Rongrong,TANG Shaoxian,YIN Lianhua,ZHOU Ping
Cancer science 101(12), 2561-2569, 2010-12-10
NAID 10027834467

Related Pictures

figure 1 cd73 generated adenosine CD73: A Novel Target for Cancer CD73 Repair of Arcam CD73 laser mechanism New Insights into Immune Cell Dysfunction Marantz cd73 cdplayer 2011ONCO0031-F1.tif

★リンクテーブル★

リンク元	「表面抗原分類」「CD13」
関連記事	「CD」

「表面抗原分類」

5'-nucleotidase, ecto (CD73)
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	4H1S, 4H1Y, 4H2B, 4H2F, 4H2G, 4H2I
Identifiers
Symbols	NT5E ; CALJA; CD73; E5NT; NT; NT5; NTE; eN; eNT
External IDs	OMIM: 129190 MGI: 99782 HomoloGene: 1895 ChEMBL: 5957 GeneCards: NT5E Gene
EC number	3.1.3.5
Gene ontology
Molecular function	• nucleotide binding; • 5'-nucleotidase activity; • metal ion binding;
Cellular component	• cytoplasm; • plasma membrane; • membrane; • anchored component of membrane; • extracellular vesicular exosome;
Biological process	• purine nucleobase metabolic process; • purine nucleotide catabolic process; • AMP catabolic process; • pyrimidine nucleobase metabolic process; • DNA metabolic process; • dephosphorylation; • small molecule metabolic process; • adenosine biosynthetic process; • pyrimidine nucleoside catabolic process; • negative regulation of inflammatory response; • nucleobase-containing small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD13」

　　[★]

同: MY7, Aminopeptidase N

概念

WCH.33

2型の膜タンパクでメタロプロテアーゼファミリー(CD10,CD26,CD73等)に属する。
ホモ2量体
遺伝子：15q25
分子量：150 kDa
発現：骨髄球系・単球系の細胞系統に発現。多くの急性骨髄性白血病と少数のリンパ芽球性白血病(5-10%)でみられる。骨髄細胞による細胞間接着による発現制御を受けており、in vitroではCD13は発現しない。その他の組織でも発現している(略)。
機能：RNAコロナウイルスの受容体。内皮の形態形成と細胞の移動性を制御しており、血管新生と腫瘍進展のいずれにおいても重要な役割を果たしている。

「CD」

　　[★]

[pmid2129526-1] Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". Eur. J. Biochem. 191 (3): 563–9. doi:10.1111/j.1432-1033.1990.tb19158.x. PMID 2129526.

[entrez-2] "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)".

[St._HilaireZiegler2011-3] St. Hilaire, Cynthia; Ziegler, Shira G.; Markello, Thomas C.; Brusco, Alfredo; Groden, Catherine; Gill, Fred; Carlson-Donohoe, Hannah; Lederman, Robert J.; Chen, Marcus Y.; Yang, Dan; Siegenthaler, Michael P.; Arduino, Carlo; Mancini, Cecilia; Freudenthal, Bernard; Stanescu, Horia C.; Zdebik, Anselm A.; Chaganti, R. Krishna; Nussbaum, Robert L.; Kleta, Robert; Gahl, William A.; Boehm, Manfred (2011). "NT5EMutations and Arterial Calcifications". New England Journal of Medicine 364 (5): 432–442. doi:10.1056/NEJMoa0912923. ISSN 0028-4793.

[4] Sharp, J. (March 1954). "Heredo-familial vascular and articular calcification". Ann. Rheum. Dis. 13 (1): 15–27. doi:10.1136/ard.13.1.15. PMC 1030367. PMID 13149051.

[5] Online 'Mendelian Inheritance in Man' (OMIM) 211800

匿名

検索

案内

案内

CD73