WordNet
- associated with or divided into zones; "a zonal pattern of cell structure"; "zonal division"
- relating to or of the nature of a zone; "the zonal frontier" (同)zonary
- the motion of charged particles in a colloid under the influence of an electric field; particles with a positive charge go to the cathode and negative to the anode (同)cataphoresis, dielectrolysis, ionophoresis
PrepTutorEJDIC
- 帯の;地域(地区)に分けられた
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- 1. 異常ヘモグロビン症の検査室診断 laboratory diagnosis of the hemoglobinopathies
- 2. モノクローナル蛋白の認識 recognition of monoclonal proteins
- 3. 形質細胞白血病 plasma cell leukemia
- 4. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma
- 5. ワルデンシュトレーム型マクログロブリン血症の疫学、病因、臨床症状、および診断 epidemiology pathogenesis clinical manifestations and diagnosis of waldenstrom macroglobulinemia
English Journal
- Proteomic analysis reveals that Adh1p is involved in a synergistic fluconazole and tetrandrine mechanism against Candida albicans.
- Zhang XL1, Zhang GH2, Wang ZY2, Guo H1, Gao LQ1, Wu S2, Song YJ1, Zhang H1.Author information 1The First Affiliated Hospital and Institute of Mycology of Jinan University, Guangzhou, China.2Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.AbstractWe previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. albicans and that the mechanism of action could be related to inhibition of a drug efflux system. To determine whether Adh1p participates in the synergistic antifungal activity of TET against C. albicans, we performed a comparative proteomic study comparing cells treated with FLC and/or TET in FLC-sensitive CA-3 and untreated control cells. Proteins were analyzed using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), and differentially expressed proteins were identified through matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF/TOF) mass spectrometry. The resulting data were searched against a C. albicans protein database. Our analyses identified six differentially expressed proteins; four (Eno1p, Adh1p, Slb1p, and Tdh1p) were down-regulated, and two (Xyl2p, and Cdc19p) were up-regulated. The Adh1p mRNA levels were consistent with the Adh1p protein levels in all of the groups. The results suggest that Adh1p participates in the synergistic antifungal activity of TET against C. albicans.
- Die Pharmazie.Pharmazie.2013 Dec;68(12):951-4.
- We previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. albicans and that the mechanism of action c
- PMID 24400441
- Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
- Zhong Q1, Shi G, Zhang Q, Zhang Y, Levy D, Zhong S.Author information 1Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 605, Los Angeles, CA 90033, USA.AbstractThe products of Pol III genes (RNA polymerase III-dependent genes), such as tRNAs and 5S rRNA, are elevated in both transformed and tumor cells suggesting that they play a crucial role in tumorigenesis. An increase in Brf1 (TFIIIB-related factor 1), a subunit of TFIIIB, augments Pol III gene transcription and is sufficient for cell transformation and tumor formation. We have demonstrated that enhancement of Brf1 and Pol III gene expression is associated with the occurrences of hepatocellular carcinoma (HCC) in mice. This suggests that Brf1 may be a key molecule during HCC development. Diethylnitrosamine (DEN), a chemical carcinogen, has been used to induce HCC in rodents. To determine the role of Brf1 and the epigenetic-regulating events in cell proliferation and transformation, hepatocytes were treated with DEN. The results indicate that DEN increases proliferation and transformation of AML-12 cells. DEN enhanced Brf1 expression and tRNA(Leu) and 5S rRNA transcription, as well as H3S10ph (phosphorylation of histone H3 serine 10). Interestingly, DEN-induced Pol III gene transcription and H3S10ph in tumor cells of liver are significantly higher than in non-tumor cells. Inhibition of H3S10ph by H3S10A attenuates the induction of Brf1 and Pol III genes. Further analysis indicates that H3S10ph occupies the promoters of Brf1 and Pol III genes to modulate their expression. Blocking H3S10ph represses cell proliferation and transformation. These results demonstrate that DEN induces H3S10ph, which mediate Brf1 expression, including but not limited Brf1-dependent genes, to upregulate Pol III gene transcription, resulting in an increase in cell proliferation and transformation.
- Carcinogenesis.Carcinogenesis.2013 Nov;34(11):2460-9. doi: 10.1093/carcin/bgt219. Epub 2013 Jun 17.
- The products of Pol III genes (RNA polymerase III-dependent genes), such as tRNAs and 5S rRNA, are elevated in both transformed and tumor cells suggesting that they play a crucial role in tumorigenesis. An increase in Brf1 (TFIIIB-related factor 1), a subunit of TFIIIB, augments Pol III gene transcr
- PMID 23774401
- Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex.
- Peng H1, Zhu QS, Zhong S, Levy D.Author information 1University of Southern California, Keck School of Medicine, Department of Biochemistry and Molecular Biology, 2011 Zonal Avenue, Los Angeles, CA 90033, USA.AbstractMicrosomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in the metabolism of numerous xenobiotics as well as mediating the sodium-dependent transport of bile acids into hepatocytes where they are involved in cholesterol excretion and metabolism, lipid digestion and regulating numerous signaling pathways. Previous studies have demonstrated the critical role of GATA-4 and a C/EBPα-NF/Y complex in the regulation of the mEH gene (EPHX1). In this study we show that HNF-4α and CAR/RXR also bind to the proximal promoter region and regulate EPHX1 expression. Bile acids, which inhibit the expression of HNF-4α also decrease the expression of EPHX1. Studies also established that the binding of HNF-4α was essential for the activation of EPHX1 activity by CAR suggesting the formation of a complex between these adjacent factors. The nature of this regulatory complex was further explored using a biotinylated oligonucleotide of this region in conjunction with BioMag beads and mass spectrometric analysis which demonstrated the presence of an additional inhibitory factor (PSF), confirmed by co-immunoprecipitation and ChIP analyses, which interacted with DNA-bound CAR/RXR/HNF-4α forming a 4-component regulatory complex.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1829(10):1000-9. doi: 10.1016/j.bbagrm.2013.05.003. Epub 2013 May 26.
- Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a central role in the metabolism of numerous xenobiotics as well as mediating the sodium-dependent transport of bile acids into hepatocytes where they are involved in cholesterol excretion and metabolism, lipid digestion and reg
- PMID 23714182
Japanese Journal
- 百寿者の日常生活自立度と血清グロブリン分画および免疫グロブリン濃度に関する研究
- 野崎 宏幸,野原 由美子,瑞慶覧 涼子,安次富 郁哉,稲福 徹也,秋坂 真史,鈴木 信
- 日本老年医学会雑誌 35(9), 680-685, 1998
- 百寿者101名 (女性77名, 男性24名) の血清グロブリンを電気泳動と免疫グロブリン定量にて検討した. 血清蛋白電気泳動にてMバンド (M蛋白) を有した百寿者数は6名 (全対象者の5.9%)で, IgG型が5名, IgA型が1名で, IgG型の1名は多発性骨髄腫が, 他の5名は本態性 (良性) 単クローン性M蛋白血症が疑われた. Mバンドを有さない百寿者95名の日常生活自立度 (ADL) と …
- NAID 130003652460
- 血管平滑筋由来泡沫細胞の形成機構に関する研究 : マクロファージと中膜平滑筋細胞相互作用の存在とその意義
- 西出 敏雄
- 千葉医学雑誌 68(1), 17-27, 1992-02-01
- … Zonal超遠心法で標識Mβ-CMを分析したところ,比重1.006(peak I)の他に1.150(peak II)にも放射活性のピークを認めた。 …
- NAID 110006174656
- ラットリポ蛋白におけるApo B(大, 小分子量)とApo Eの分布
- 玉井 利孝,中井 継彦,宮保 進,PATSCH Wolfgang,SCHONFELD Gustav
- 動脈硬化 13(3), 701-706, 1985
- … The d=1.006-1.070 fraction was subjected to zonal ultracentrifugation in a 14 Ti rotor using a linear NaBr density gradient spanning the densities 1.000 to 1.300g/ml. … The faster floating population had zonal floatation properties similar to that of human LDL and was therefore designated LDL. … Proportion of various apoproteins of lipoproteins were assessed by SDS polyacrylamide gel electrophoresis. …
- NAID 130004883214
Related Links
- Zonal electrophoresis information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Zonal electrophoresis: Related Topics These medical condition or symptom topics may be ...
- zone electrophoresis any of several methods of electrophoresis in which an inert support medium holds the molecules as they migrate in the conducting medium, thus preventing convection and diffusion ... zonal electrophoresis zone ...
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★リンクテーブル★
| リンク元 | 「分域電気泳動」「ゾーン電気泳動」「zone electrophoresis」 |
| 関連記事 | 「electrophoresis」「zona」「zonal」 |
「分域電気泳動」
「ゾーン電気泳動」
「zone electrophoresis」
「electrophoresis」
「zona」
- n.
「zonal」
- adj.
- 帯状の、地帯の、ゾーンの