人全血液

WordNet

including all components without exception; being one unit or constituting the full amount or extent or duration; complete; "gave his whole attention"; "a whole wardrobe for the tropics"; "the whole hog"; "a whole week"; "the baby cried the whole trip home"; "a whole loaf of bread"
an assemblage of parts that is regarded as a single entity; "how big is that part compared to the whole?"; "the team is a unit" (同)unit
all of something including all its component elements or parts; "Europe considered as a whole"; "the whole of American literature"
(of siblings) having the same parents; "whole brothers and sisters"
sing with closed lips; "She hummed a melody"
a humming noise; "the hum of distant traffic" (同)humming
be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
sound with a monotonous hum (同)thrum
make a low continuous sound; "The refrigerator is humming"
smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
temperament or disposition; "a person of hot blood"
people viewed as members of a group; "we need more young blood in this organization"
the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea
relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
characteristic of humanity; "human nature"
having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"

PrepTutorEJDIC

《the ~,one's ~ の形で名詞の前に用いて》『全体の』,全部の,全… / 《名詞の前にのみ用いて》(時間・距離などが)『まる』…,満… / (物が)完全な,欠けていない;《名詞の後に置いて》丸ごとで,ひとかたまりに / 《冠詞をつけずに複数名詞の前に用いて》ひじょうに多くの / 《古》(人が)無傷の,(肉体的に)健康な / 整数の,分数を含まない / 〈U〉《the ~》(…の)『全部』,全体,全量《+of+名》 / 〈C〉完全なもの,統一体
〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
(動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
《疑問代名詞》『だれが』,どんな人が / 《関係代名詞》(先行詞は「人」) / 《制限用法》(…する,…した)『ところの』 / 《非制限用法》『そしてその人は(を)』,それは…する(した)人だが / 《古》《先行詞を含んで》…する人[はだれでも]

UpToDate Contents

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1. 輸血への赤血球使用 use of red blood cells for transfusion
2. 胎児の採血 fetal blood sampling
3. 重症患者における血液製剤の使用 use of blood products in the critically ill
4. 輸血関連急性肺障害（TRALI） transfusion related acute lung injury trali
5. 幼児および小児における赤血球輸血の適応 indications for red blood cell transfusion in infants and children

English Journal

Selective capture of human red blood cells based on blood group using long-range surface plasmon waveguides.

Krupin O, Wang C, Berini P.Author information Department of Biological and Chemical Engineering, University of Ottawa, 161 Louis Pasteur, Ottawa, Ontario, Canada K1N 6N5.AbstractAn optical biosensor based on long-range surface plasmon-polariton waveguides is applied to the detection of blood group antigen A on whole erythrocytes. The biosensor consists of straight gold waveguides embedded in CYTOP with an etched fluidic channel. The gold waveguides were functionalized with immunoglobulin G against blood group A (anti-A IgG) by forming a self-assembled monolayer (SAM) of 16-mercaptohexadecanoic acid (16-MHA) and then conjugating the anti-A IgG through carbodiimide chemistry. In order to demonstrate anti-A surface selectivity, solutions of O-type, B-type, A-type and AB-type red blood cells (RBCs) were sequentially injected over an anti-A functionalized waveguide. Surfaces were regenerated by lysing attached cells with distilled/deionized water (DDI H2O). The efficiency of surface regeneration with DDI H2O was very high as determined by performing six sequential binding/regeneration cycles of A RBC capture on the same anti-A surface. Also, five solutions of different A RBC concentrations, ranging from 1.14×10(5)cells/ml to 1.83×10(6)cells/ml, were injected over an anti-A surface to determine the limit of detection (LOD), which was found to be less than 3×10(5)cells/ml. Finally, the response produced by a single cell bound to a waveguide was determined by relating the number of bound cells to the response produced, from which the signal-to-noise ratio for single cell detection was determined to be ~95. The waveguides are promising as simple, low-cost and compact transducers, functionalized using standard thiol-based chemistries, for the selective detection of cells.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Mar 15;53:117-22. doi: 10.1016/j.bios.2013.09.051. Epub 2013 Sep 29.
An optical biosensor based on long-range surface plasmon-polariton waveguides is applied to the detection of blood group antigen A on whole erythrocytes. The biosensor consists of straight gold waveguides embedded in CYTOP with an etched fluidic channel. The gold waveguides were functionalized with
PMID 24135542

Copper, zinc superoxide dismutase and nitrate reductase coimmobilized bienzymatic biosensor for the simultaneous determination of nitrite and nitrate.

Madasamy T, Pandiaraj M, Balamurugan M, Bhargava K, Sethy NK, Karunakaran C.Author information Biomedical Research Laboratory, Department of Chemistry, VHNSN College (Autonomous), Virudhunagar 626001, Tamil Nadu, India.AbstractThis work presents a novel bienzymatic biosensor for the simultaneous determination of nitrite (NO2(-)) and nitrate (NO3(-)) ions using copper, zinc superoxide dismutase (SOD1) and nitrate reductase (NaR) coimmobilized on carbon nanotubes (CNT)-polypyrrole (PPy) nanocomposite modified platinum electrode. Morphological changes of the PPy and CNT modified electrodes were investigated using scanning electron microscopy. The electrochemical behavior of the bienzymatic electrode (NaR-SOD1-CNT-PPy-Pt) was characterized by cyclic voltammetry exhibiting quasi-reversible redox peak at +0.06 V and reversible redox peaks at -0.76 and -0.62V vs. Ag/AgCl, for the immobilized SOD1 and NaR respectively. The electrocatalytic activity of SOD1 towards NO2(-) oxidation observed at +0.8 V was linear from 100 nM to 1mM with a detection limit of 50 nM and sensitivity of 98.5 ± 1.7 nA µM(-1)cm(-2). Similarly, the coimmobilized NaR showed its electrocatalytic activity towards NO3(-) reduction at -0.76 V exhibiting linear response from 500 nM to 10mM NO3(-) with a detection limit of 200 nM and sensitivity of 84.5 ± 1.56 nA µM(-1)cm(-2). Further, the present bienzymatic biosensor coated with cellulose acetate membrane for the removal of non-specific proteins was used for the sensitive and selective determinations of NO2(-) and NO3(-) present in human plasma, whole blood and saliva samples.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Feb 15;52:209-15. doi: 10.1016/j.bios.2013.08.036. Epub 2013 Aug 28.
This work presents a novel bienzymatic biosensor for the simultaneous determination of nitrite (NO2(-)) and nitrate (NO3(-)) ions using copper, zinc superoxide dismutase (SOD1) and nitrate reductase (NaR) coimmobilized on carbon nanotubes (CNT)-polypyrrole (PPy) nanocomposite modified platinum elect
PMID 24055935

Optimized selection of anti-tumor recombinant antibodies from phage libraries on intact cells.

Pavoni E, Vaccaro P, Anastasi AM, Minenkova O.Author information Biotechnology, Sigma-tau, SpA, via Pontina km 30.400, Pomezia (RM) 00040, Italy. Electronic address: emiliano.pavoni@email.it.AbstractGeneration of human recombinant antibody libraries displayed on the surface of the filamentous phage and selection of specific antibodies against desirable targets allows production of fully human antibodies usable for repeated administration in humans. Various lymphoid tissues from immunized donors, such as lymph nodes or peripheral blood lymphocytes from individuals with tumor or lymphocytes infiltrating tumor masses may serve as a source of specific anti-tumor antibody repertoire for generation of tumor-focused phage display libraries. In the case of lack of tumor-associated antigens in the purified form, high affinity anti-tumor antibodies can be isolated through library panning on whole cells expressing these antigens. However, affinity selection against cell surface specific antigens within highly heterogeneous population of molecules is not a very efficient process that often results in the selection of unspecific antibodies or antibodies against intracellular antigens that are generally useless for targeted immunotherapy. In this work, we developed a new cell-based antibody selection protocol that, by eliminating the contamination of dead cells from the cell suspension, dramatically improves the selection frequency of anti-tumor antibodies recognizing cell surface antigens.
Molecular immunology.Mol Immunol.2014 Feb;57(2):317-22. doi: 10.1016/j.molimm.2013.10.009. Epub 2013 Nov 13.
Generation of human recombinant antibody libraries displayed on the surface of the filamentous phage and selection of specific antibodies against desirable targets allows production of fully human antibodies usable for repeated administration in humans. Various lymphoid tissues from immunized donors
PMID 24240062

Japanese Journal

Quantitative Determination of Cyclosporine in Human Whole Blood by Ultra-Performance Liquid Chromatography with Triple Quadrupole Tandem Mass Spectrometry

JUNG Hyun Jin,GWON Mi-Ri,PARK Jeonghyeon [他]
Analytical Sciences 30(2), 293-298, 2014-02
NAID 40019987706

抗フィブロネクチンモノクローナル抗体MOの反応性の検討

岡田眞理子,福岡史奈,佐川輝高,櫃本泰雄
生物試料分析 36(5), 366-372, 2013-12-20
… The properties of an anti-fibronectin monoclonal antibody MO which recognizes an epitope on a subpopulation of human neutrophils were examined. … Flow cytometric analysis revealed that the ratio of the MO-binding subpopulation of neutrophils increased by the stimulation of whole blood with formyl-methyonyl-leucyl-phenylalanine. …
NAID 120005387543

Morphologic, flow cytometric, functional, and molecular analyses of S100B positive lymphocytes, unique cytotoxic lymphocytes containing S100B protein

Miki Yukari,Gion Yuka,Mukae Yuriko,Hayashi Atsushi,Sato Hiaki,Yoshino Tadashi,Takahashi Kiyoshi
European Journal of Haematology 90(2), 99-110, 2013-02
… Little is known about the S100B+ lymphocytes, which are unique human peripheral blood lymphocytes (PBL) containing the S100B protein. … In this study, we precisely characterized the S100B+ lymphocytes of healthy adults with respect to the proportion in the whole PBL, immunophenotypes, function, and their S100B mRNA expression and also evaluated their S100B-releasing activity upon stimulation. …
NAID 120005311989