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1. バラシクロビル：概要 valacyclovir an overview
2. 性器単純ヘルペスウイルス感染の治療 treatment of genital herpes simplex virus infection
3. 免疫正常患者における帯状疱疹の治療 treatment of herpes zoster in the immunocompetent host
4. 腎移植レシピエントにおけるサイトメガロウイルス感染 cytomegalovirus infection in renal transplant recipients
5. HIV感染患者における2型性器単純ヘルペスウイルスの治療 treatment of genital herpes simplex virus type 2 in hiv infected patients

Formulation development, optimization, and evaluation of sustained release tablet of valacyclovir hydrochloride by combined approach of floating and swelling for better gastric retention.

Upadhyay P1, Nayak K, Patel K, Patel J, Shah S, Deshpande J.
Drug delivery and translational research.Drug Deliv Transl Res.2014 Dec;4(5-6):452-64. doi: 10.1007/s13346-014-0207-x.
The present study is intended to enhance gastric retention of sustained release tablet of valacyclovir hydrochloride by combined approach of floating and swelling. The tablets are prepared by direct compression method. Polyethylene oxide (Polyox WSR 303) is selected as the swelling matrix agent. Sod
PMID 25787207

[Enantiomeric separation and impurity determination of valaciclovir hydrochloride].

Zhu QY1, Yu LS1, Zheng GG2, Xie SG2, Tao QF3.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.Zhejiang Da Xue Xue Bao Yi Xue Ban.2014 Mar;43(2):164-7.
OBJECTIVE: To determine the contents of L-enantiomer impurity in valaciclovir hydrochloride.METHODS: Valaciclovir enantiomers were separated and determined by using chiral high performance liquid chromatography. Chromatographic conditions were as follows:CROWNPAK(®) CR(+) chiral column (4 mm×150 m
PMID 24782372

Kinetic Study of the Alkaline Degradation of Oseltamivir Phosphate and Valacyclovir Hydrochloride using Validated Stability Indicating HPLC.

Al-Bagary RI1, El-Zaher AA1, Morsy FA2, Fouad MM2.
Analytical chemistry insights.Anal Chem Insights.2014 May 27;9:41-8. doi: 10.4137/ACI.S13878. eCollection 2014.
Aqueous alkaline degradation was performed for oseltamivir phosphate (OP) and valacyclovir hydrochloride (VA). Isocratic stability indicating the use of high-performance liquid chromatography (HPLC) was presented for each drug in the presence of its degradation product. The separations were performe
PMID 24932100

Drug Interaction Studies Reveal That Simotinib Upregulates Intestinal Absorption by Increasing the Paracellular Permeability of Intestinal Epithelial Cells

ZHU Qubo,LIU Zhifang,LI Pei,CHENG Zeneng
Drug Metabolism and Pharmacokinetics 29(4), 317-324, 2014
… Hypothesis: Simotinib hydrochloride (SIM6802), which is a new epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR-TKI), is often prescribed for cancer patients with comorbidities and has serious adverse effects on gastrointestinal physiology. … Results: Our research demonstrated that simotinib upregulated the absorption of cefaclor, valaciclovir and acyclovir. …
NAID 130004463390