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A variant of CLEC16A gene confers protection for Vogt-Koyanagi-Harada syndrome but not for Behcet's disease in a Chinese Han population.

Li K1, Hou S2, Qi J2, Kijlstra A3, Yang P4.
Experimental eye research.Exp Eye Res.2015 Mar;132:225-30. doi: 10.1016/j.exer.2015.01.004. Epub 2015 Jan 7.
Vogt-Koyanagi-Harada (VKH) syndrome and Behcet's disease (BD) are two common form of uveitis in China. The aim of this study was to investigate the association of C-type lectin domain family 16, member A (CLEC16A) gene polymorphisms with Vogt-Koyanagi-Harada syndrome and Behcet's disease in a Chines
PMID 25576669

Genetic variations of IL17F and IL23A show associations with Behçet's disease and Vogt-Koyanagi-Harada syndrome.

Hou S1, Liao D2, Zhang J2, Fang J2, Chen L2, Qi J2, Zhang Q2, Liu Y2, Bai L2, Zhou Y2, Kijlstra A3, Yang P4.
Ophthalmology.Ophthalmology.2015 Mar;122(3):518-23. doi: 10.1016/j.ophtha.2014.09.025. Epub 2014 Nov 15.
PURPOSE: To investigate the associations of IL17A, IL17F, IL23A, and IL23R copy number variants (CNVs) with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) and the possible mechanisms involved.DESIGN: Two-stage case-control and functional studies.PARTICIPANTS: A total of 1159 VKH pati
PMID 25439430

High C4 gene copy numbers protects against Vogt-Koyanagi-Harada syndrome in Chinese Han.

Hou S1, Qi J1, Liao D1, Fang J1, Chen L1, Kijlstra A2, Yang P1.
The British journal of ophthalmology.Br J Ophthalmol.2014 Dec;98(12):1733-7. doi: 10.1136/bjophthalmol-2014-305596. Epub 2014 Sep 2.
AIMS: Considering the phenotypical consequences and association of C4 copy number variation (CNV) with various autoimmune diseases, we aimed to examine C4 CNVs for 1027 patients with Vogt-Koyanagi-Harada (VKH) syndrome and 2083 controls.METHODS: C4 CNVs were examined by real-time PCR for 1027 patien
PMID 25185257