upstream open reading frame

上流オープンリーディングフレーム

関

uORF

WordNet

1. without undue constriction as from e.g. tenseness or inhibition; "the clarity and resonance of an open tone"; "her natural and open response"
2. a clear or unobstructed space or expanse of land or water; "finally broke out of the forest into the open" (同)clear
3. information that has become public; "all the reports were out in the open"; "the facts had been brought to the surface" (同)surface
4. a tournament in which both professionals and amateurs may play
5. become available; "an opportunity opened up" (同)open_up
6. become open; "The door opened" (同)open_up
7. cause to open or to become open; "Mary opened the car door" (同)open_up
8. make available; "This opens up new possibilities" (同)open_up
9. start to operate or function or cause to start operating or functioning; "open a business" (同)open_up
10. not sealed or having been unsealed; "the letter was already open"; "the opened package lay on the table" (同)opened
11. used of mouth or eyes; "keep your eyes open"; "his mouth slightly opened" (同)opened
12. not brought to a conclusion; subject to further thought; "an open question"; "our position on this bill is still undecided"; "our lawsuit is still undetermined" (同)undecided, undetermined, unresolved
13. affording unobstructed entrance and exit; not shut or closed; "an open door"; "they left the door open" (同)unfastened
14. (set theory) of an interval that contains neither of its endpoints
15. accessible to all; "open season"; "an open economy"
16. affording free passage or access; "open drains"; "the road is open to traffic"; "open ranks"
17. begin or set in action, of meetings, speeches, recitals, etc.; "He opened the meeting with a long speech"
18. display the contents of a file or start an application as on a computer
19. have an opening or passage or outlet; "The bedrooms open into the hall"
20. having no protecting cover or enclosure; "an open boat"; "an open fire"; "open sports cars"
21. make the opening move; "Kasparov opened with a standard opening"
22. not having been filled; "the job is still open"
23. not requiring union membership; "an open shop employs nonunion workers"
24. open to or in view of all; "an open protest"; "an open letter to the editor"
25. ready for business; "the stores are open"
26. enclose in a frame, as of a picture
27. a framework that supports and protects a picture or a mirror; "the frame enhances but is not itself the subject of attention"; "the frame was much more valuable than the miror it held" (同)framing
28. a single one of a series of still transparent pictures forming a cinema, television or video film
29. one of the ten divisions into which bowling is divided
30. the framework for a pair of eyeglasses
31. a single drawing in a comic_strip
32. an application that divides the users display into two or more windows that can be scrolled independently
33. make up plans or basic details for; "frame a policy" (同)compose, draw_up
34. enclose in or as if in a frame; "frame a picture" (同)frame in, border
35. construct by fitting or uniting parts together (同)frame up
36. formulate in a particular style or language; "I wouldnt put it that way"; "She cast her request in very polite language" (同)redact, cast, put, couch
37. first or beginning; "the memorable opening bars of Beethovens Fifth"; "the plays opening scene"
38. opportunity especially for employment or promotion; "there is an opening in the sales department"
39. a recognized sequence of moves at the beginning of a game of chess; "he memorized all the important chess openings" (同)chess opening
40. a vacant or unobstructed space that is man-made; "they left a small opening for the cat at the bottom of the door"
41. becoming open or being made open; "the opening of his arms was the sign I was waiting for"
42. the act of opening something; "the ray of light revealed his cautious opening of the door"
43. an open or empty space in or between things; "there was a small opening between the trees"; "the explosion made a gap in the wall" (同)gap
44. the first performance (as of a theatrical production); "the opening received good critical reviews" (同)opening_night, curtain raising
45. a ceremony accompanying the start of some enterprise
46. the initial part of the introduction; "the opening established the basic theme"
47. the act of measuring with meters or similar instruments; "he has a job meter reading for the gas company" (同)meter reading
48. a datum about some physical state that is presented to a user by a meter or similar instrument; "he could not believe the meter reading"; "the barometer gave clear indications of an approaching storm" (同)meter reading, indication
49. written material intended to be read; "the teacher assigned new readings"; "he bought some reading material at the airport" (同)reading material
50. a particular interpretation or performance; "on that reading it was an insult"; "he was famous for his reading of Mozart"
51. the cognitive process of understanding a written linguistic message; "his main reading was detective stories"; "suggestions for further reading"
52. in the direction against a streams current

PrepTutorEJDIC

1. …‘を'『開く』,開ける;…‘の'ふた(おおい)をとる / …‘を'『切り開いて作る』,開拓する;…‘を'全開通させる《+『名』+『up,』+『名』+『up』》 / …‘を'『広げる』《+『up』+(『out』)+『名,』+『名』+『up』(『out』)》 / …‘を'『始める』 / …‘を'開業する,開店する,開場する / (人に)〈心など〉‘を'打ち明ける,〈秘密など〉‘を'漏らす《+『名』+『to』+『名』》 / (新思想などに)〈心・目〉‘を'開く《+『名』+『to』+『名』》 / 〈戸などが〉『開く』,あく / 〈花・つぼみが〉開く《+『out』》 / 〈学校などが〉『始まる』;〈店などが〉開く / 〈道路などが〉開通する / (…に)向かって開いている,(…に)通じている《+『out』『on』(『upon,to,onto』)+『名』》 / 《副詞[句]を伴って》〈風景などが〉広がる,ひらける / 本を開く;(…)ページを開く《+『to』(《英》『at』)+『名』》 / (窓・口などが)『開いた』,開いている;(包みなどが)広げられて / (花が)咲いた / (店などが)『開いている』,開業している;(催し物が)『公開の』,だれでも入れる / 《名詞の前にのみ用いて》ふたのしてない,屋根のない,おおいのない / 広く開いた,さえぎるものがない / 公然の / 率直な,遠慮しない / さらされている,無防備の / 《補語にのみ用いて》(職・地位などが)空位の;(時間などが)あいている / (問題・議事などが)未解決の / 凍結しない,雪や霜の降らない;温和な / (漁・猟が)解禁の / (音声が)開口音の;開音節の / 《the~》戸外,野外 / 空き地;(樹木のない)開けた場所,平野
2. 〈C〉(建造物・機械などの)『骨組み』《+『of』+『名』》 / 〈C〉(戸・窓などの)『枠』;額縁《+『of』+『名』》《複数形で》めがねの枠 / 〈C〉『体格』 / 〈C〉(…の)構造,体制《+『of』+『名』》 / 〈C〉(簡略な)温室,温床 / 〈C〉(ボーリングで)フレーム(10回で1ゲームを構成するその各回);各回の得点を記入する枠 / 〈C〉(映画のフイルムの)一こま / 《修飾語を伴って》《a~》気持ち,気分 / (組み合わせて)…‘を'『形作る』,組み立てる;(ある目的などに合うように)〈人・物〉‘を'作り上げる / 〈考え・構想など〉‘を'心に抱く / 〈絵など〉‘を'粋に入れる,縁どる / 〈言葉など〉‘を'言う / 《話》〈人〉‘に'ぬれぎぬを着せる
3. 〈C〉(森・垣根・壁などの)空いている所;空き地;すき間,穴 / 〈C〉(物語・会議などの)始め,出だし,冒頭(beginning) / 〈C〉(…の地位の)空き,就職口《+『for』(『at, in』)+『名』》(vacant) / 〈C〉(劇などの)初演 / 〈U〉(…が)開くこと,あくこと《+『of』+『名』》 / 〈C〉(…の)よい機会,好機《+『for』+『名』》 / 初めの,開始の
4. 〈U〉『読書』 / 〈U〉(読書によって得た)知識,学識 / 〈U〉朗読;〈C〉朗読会 / 〈U〉読みもの;《複数形で》(…の)選集,文選《+『from』+『名』》 / 〈C〉(劇の役・楽曲・文章などの)解釈《+『of』+『名』》 / 〈C〉(計器などの)示度 / 読書する / 読書用の
5. 上流に,流れおさかのぼって / 上流の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/07 13:17:23」(JST)

wiki en

[Wiki en表示]

An Upstream Open Reading Frame (uORF) is a very short Open Reading Frame (ORF) within the 5'untranslated region of a mRNA that is a common mechanism for the regulation of eukaryotic genes expression. Expression of the uORF typically interferes with the expression of a downstream primary ORF, which corresponds to the gene under regulation. In bacteria, uORFs are called leader peptides, and were originally discovered on the basis of their impact on the regulation of genes involved in the synthesis or transport of amino acids.

References

UpToDate Contents

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• 1. MERSコロナウイルス：臨床症状および診断 middle east respiratory syndrome coronavirus clinical manifestations and diagnosis
• 2. 遺伝学：用語集 genetics glossary of terms
• 3. 開腹下胆嚢摘出術 open cholecystectomy
• 4. Molecular genetics of the thalassemic syndromes
• 5. Open globe injuries: Emergency evaluation and initial management

English Journal

• Analytical and Clinical Validation of Six Commercial Middle East Respiratory Syndrome Coronavirus RNA Detection Kits Based on Real-Time Reverse-Transcription PCR.

• Kim MN1, Ko YJ2, Seong MW3, Kim JS4, Shin BM5, Sung H2.
• Annals of laboratory medicine.Ann Lab Med.2016 Sep;36(5):450-6. doi: 10.3343/alm.2016.36.5.450.
• BACKGROUND: During the 2015 outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV), six different commercial MERS-CoV RNA detection kits based on real-time reverse-transcription polymerase chain reaction (rRT-PCR) were available in Korea. We performed analytical and clinical validations
• PMID 27374710

• The cag-pathogenicity island encoded CncR1 sRNA oppositely modulates Helicobacter pylori motility and adhesion to host cells.

• Vannini A1, Roncarati D1, Danielli A2.
• Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2016 Aug;73(16):3151-68. doi: 10.1007/s00018-016-2151-z. Epub 2016 Feb 10.
• Small regulatory RNAs (sRNAs) are emerging as key post-transcriptional regulators in many bacteria. In the human pathobiont Helicobacter pylori a plethora of trans- and cis-encoded sRNAs have been pinpointed by a global transcriptome study. However, only two have been studied in depth at the functio
• PMID 26863876

• Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

• Liang XH1, Shen W1, Sun H1, Migawa MT2, Vickers TA1, Crooke ST1.
• Nature biotechnology.Nat Biotechnol.2016 Aug;34(8):875-80. doi: 10.1038/nbt.3589. Epub 2016 Jul 11.
• Increasing the levels of therapeutic proteins in vivo remains challenging. Antisense oligonucleotides (ASOs) are often used to downregulate gene expression or to modify RNA splicing, but antisense technology has not previously been used to directly increase the production of selected proteins. Here
• PMID 27398791

Japanese Journal

• Galactose oxidase/kelch repeat-containing protein is involved in the iron deficiency stress response in the roots of <i>Hyoscyamus albus</i>

• Kawahara Yuki,Hashimoto Takashi,Nakayama Hideki,Kitamura Yoshie
• Plant Root 11(0), 58-63, 2017
• … To confirm the involvement of galactose oxidase/kelch repeat-containing protein (Glx) in response to iron (Fe) deficiency in Hyoscyamus albus, we cloned a putative full-length HaGlx cDNA, which contained an open reading frame (975 bp, 324 amino acids). …
• NAID 130006233706

• The SAC51 Family Plays a Central Role in Thermospermine Responses in Arabidopsis

• Cai Qingqing,Fukushima Hiroko,Yamamoto Mai,Ishii Nami,Sakamoto Tomoaki,Kurata Tetsuya,Motose Hiroyasu,Takahashi Taku
• Plant and Cell Physiology 57(8), 1583-1592, 2016-08
• … The sac51-d mutant has a premature termination codon in an upstream open reading frame (uORF) that is conserved among all four members of the SAC51 family, SAC51 and SACL1-SACL3 This suggests that thermospermine cancels the inhibitory effect of the uORF in main ORF translation. …
• NAID 120006348277

• Characterization of the <i>TRAF3IP1</i> gene in Yesso scallop (<i>Patinopecten yessoensis</i>) and its expression in response to bacterial challenge

• Cheng Jie,Wang Jing,Wang Shuyue,Li Ruojiao,Ning Xianhui,Xing Qiang,Ma Xiaoli,Zhang Lingling,Wang Shi,Hu Xiaoli,Bao Zhenmin
• 遺伝学雑誌 91(5), 267-276, 2016
• … <p>Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an important adaptor that transmits upstream activation signals to induce innate immune responses. … cDNA is 2,367 bp, with an open reading frame of 1,629 bp encoding 542 amino acids. …
• NAID 130005548844

Related Links

• Gene Expression Regulation by Upstream Open Reading ...

Upstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryotic mRNAs, one or more uORFs precede the initiation codon of the main coding region. Indeed, several studies have revealed ...

• Upstream open reading frames: Molecular switches in (patho ...

Conserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF-mediated translational control in the ...

• Upstream Open Reading Frame - an overview | ScienceDirect ...

Alan Urban, Jean Rossier, in Progress in Brain Research, 2012Adeno-associated vectors AAV is a small (25 nm diameter), non-enveloped, and single-stranded DNA parvovirus.The upstream open reading frame encodes four replication (rep) proteins that allow AAV rep-proteins to package AAV ITR-flanked transgenes into nearly all serotype virions.

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★リンクテーブル★

リンク元	「uORF」「上流オープンリーディングフレーム」
関連記事	「reading」「open」「opening」「frame」「reading frame」

「uORF」

　　[★]

• 上流オープンリーディングフレーム

関

upstream open reading frame

「上流オープンリーディングフレーム」

　　[★]

英

upstream open reading frame、uORF

「reading」

　　[★]

• n.

• 読書。読書能力。朗読。朗読会。(議会の)読み会
• (書物による)学問研究。読書量。学識
• 判断、解釈。(脚本の)演出。(楽曲の)演奏。(写本・原稿などの)読み方(version)、異文
• 読物
• (晴雨計、温度計などの)示度、示数、記録

• adj.

• 読書の/読書用の、読むための。読書する、本好きの。勤勉な

　 　 　 　 　 　

「open」

　　[★]

• n.

• 開く、オープン

• v.

• 開口する、開放する、開放性の、開放的な

関

aperture、liberal、opening、orificial

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「opening」

　　[★]

• n.

• 開口

関

aperture、open、orificial

　 　 　 　 　 　 　 　 　 　 　

「frame」

　　[★]

• 骨組み、枠、フレーム

　 　 　 　 　 　 　 　 　 　 　 　

「reading frame」

　　[★]

• 読み枠

関

open reading frame