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- upstream open reading frame
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/21 01:28:48」(JST)
[Wiki en表示]
An Upstream Open Reading Frame (uORF) is an Open Reading Frame (ORF) within the 5'UTR (5' untranslated region) of a mRNA. uORFs can regulate eukaryotic gene expression.[1][2] Translation of the uORF typically inhibits downstream expression of the primary ORF. In bacteria, uORFs are called leader peptides, and were originally discovered on the basis of their impact on the regulation of genes involved in the synthesis or transport of amino acids.
See also
References
- ^ Vilela C, McCarthy JE (August 2003). "Regulation of fungal gene expression via short open reading frames in the mRNA 5'untranslated region". Mol. Microbiol. 49 (4): 859–67. doi:10.1046/j.1365-2958.2003.03622.x. PMID 12890013.
- ^ Lovett PS, Rogers EJ (June 1996). "Ribosome regulation by the nascent peptide". Microbiol. Rev. 60 (2): 366–85. PMC 239448. PMID 8801438.
English Journal
- An inhibitory effect of the sequence-conserved upstream open-reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis.
- Zhu X, Thalor SK, Takahashi Y, Berberich T, Kusano T.SourceGraduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai-city, Miyagi 980-8577, Japan.
- Plant, cell & environment.Plant Cell Environ.2012 Nov;35(11):2014-30. doi: 10.1111/j.1365-3040.2012.02533.x. Epub 2012 May 31.
- Plants have as many as 20 heat shock factors (Hsfs) grouped into three classes, A, B and C, based on sequence similarity and modular structures. Through screening for cell death-inducing factor(s) in Nicotiana benthamiana, we identified Arabidopsis HsfB2b and thus subjected all other members of Arab
- PMID 22571635
- BAIUCAS: a novel BLAST-based algorithm for the identification of upstream open reading frames with conserved amino acid sequences and its application to the Arabidopsis thaliana genome.
- Takahashi H, Takahashi A, Naito S, Onouchi H.SourcePlant Biology Research Center, Chubu University, Kasugai, Aichi, Japan.
- Bioinformatics (Oxford, England).Bioinformatics.2012 Sep 1;28(17):2231-41. doi: 10.1093/bioinformatics/bts303. Epub 2012 May 21.
- MOTIVATION: Upstream open reading frames (uORFs) are often found in the 5'-untranslated regions of eukaryotic messenger RNAs. Some uORFs have been shown to encode functional peptides involved in the translational regulation of the downstream main ORFs. Comparative genomic approaches have been used i
- PMID 22618534
Japanese Journal
- Genome-wide comparative analysis of Oryza sativa (japonica) and Arabidopsis thaliana 5'-UTR sequences for translational regulatory signals
- SHASHIKANTH M.,KRISHNA A. R.,RAMYA G.,DEVI Geeta,ULGANATHAN K.
- Plant biotechnology 25(6), 553-563, 2008-12-01
- Untranslated regions of eukaryotic genes contain elements that in combination with proteins/RNAs modulate translation of individual messenger RNAs. Elements present in 5′-UTRs that influence translati …
- NAID 10023988135
- Characterization of a dehydrogenase motif and an uORF in Arabidopsis ANGUSTIFOLIA gene
- CHO Kiu-Hyung,TSUKAYA Hirokazu,KIM Gyung-Tae
- Plant biotechnology 25(4), 365-368, 2008-09-01
- … Moreover, we found that AN has an additional short open reading frame (ORF), which was identified as an upstream ORF (uORF), in its 5′-untranslated region that overlaps with the start codon of the AN gene. … Transcriptional analysis revealed that the uORF and AN ORF are transcribed as a single molecule, indicating that the uORF might influence AN transcription during leaf development. …
- NAID 10021914183
Related Links
- シロイヌナズナにおけるuORF にコードされるペプチドによる 翻訳制御の探索と解析 生命科学院 生命科学専攻 環境応答統御科学分野 蝦名 績 <背景> 真核生物の30~50%のmRNAには5’非翻訳領域に小さなORF(upstream ORF: uORF ...
- uORF(upstream open reading frame).成熟mRNAのコーディング領域の5′上流に存在するタンパク質をコードする可能性がある読み取り枠のこと.5′上流の非翻訳領域にあるuORFによって,下流ORFの翻訳活性や読み取り枠の選択が調節 ...
Related Pictures
★リンクテーブル★
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上流オープンリーディングフレーム
- 関
- uORF
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- 英
- upstream open reading frame、uORF