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1. 基礎疾患の状態、環境曝露、およびその他の原因による二次性免疫不全症secondary immunodeficiency due to underlying disease states environmental exposures and miscellaneous causes [show details]
…immune dysfunction is regularly encountered are presented in this section. Neutrophil dysfunction underlies much of the predisposition to bacterial and fungal infections found in patients with diabetes . …
2. 肺移植：疾患に基づいた処置の選択lung transplantation disease based choice of procedure [show details]
…lung transplant procedures, the most common diseases that require lung transplant, and how the underlying lung disease affects the choice of procedure will be reviewed here. An overview of lung transplantation …
3. 小児の慢性腎臓病：定義、疫学、病因、経過chronic kidney disease in children definition epidemiology etiology and course [show details]
…functioning nephrons. A reduction in GFR implies a decrease in the number of functioning nephrons due to underlying disease/injury, which may or may not be reversible. Clinically, GFR is estimated from the urinary …
4. 成人の急性腎障害における腎前性疾患と急性尿細管壊死の病因および診断etiology and diagnosis of prerenal disease and acute tubular necrosis in acute kidney injury in adults [show details]
…examination can frequently identify events and/or disease processes that underlie prerenal disease or ATN, suggesting the underlying diagnosis. In addition to a careful history and physical examination …
5. 慢性疾患／炎症時の貧血anemia of chronic disease inflammation [show details]
…associated disorders . Typically, the underlying disorder(s) responsible for ACD will be known to the patient and the clinician. Therapy for the underlying disorder should be pursued, with the specific …

English Journal

PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease.

, B B, S S, S S, .
Adipocyte. 2019 Dec;8(1)201-208.
Fatty liver disease (FLD) affects more than one-third of the population in the western world and an increasing number of children in the United States. It is a leading cause of obesity and liver transplantation. Mechanistic insights into the causes of FLD are urgently needed since no therapeutic int
PMID 31062641

Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells.

Fu X, Zhu J, Zhang L, Shu J.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1782-1787.
Hepatic steatosis is one of the most important features of the pathogenesis for non-alcoholic fatty liver disease. Fat deposition in liver cells can influence hepatic lipogenesis along with other metabolic pathways and further lead to the irreversible liver cirrhosis and injury. However, the underly
PMID 31062612

LncRNA FOXD2-AS1 induces chondrocyte proliferation through sponging miR-27a-3p in osteoarthritis.

Wang Y, Cao L, Wang Q, Huang J, Xu S.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1241-1247.
Osteoarthritis (OA) is a common degenerative joint disease worldwide. Long non-coding RNAs (lncRNAs) have been widely confirmed to involve in the modulation of OA progression. However, the underlying mechanisms of lncRNA FOXD2-AS1 in OA remain unclear. In the present study, we showed FOXD2-AS1 expre
PMID 30945573

Japanese Journal

Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells

Nakajima Taiki,Ikeya Makoto
Regenerative Therapy (11), 25-30, 2019-12
… Recently, several researchers have attempted to apply induced pluripotent stem cell (iPSC) technology as a powerful tool for studying the mechanisms underlying the onset of various diseases and for new drug screening. … This technology has made an enormous breakthrough, since it permits us to recapitulate the disease phenotype in vitro, outside of the patient's body. …
NAID 120006630969

Integrative network analysis reveals biological pathways associated with Williams syndrome

Kimura Ryo,Swarup Vivek,Tomiwa Kiyotaka,Gandal Michael J.,Parikshak Neelroop N.,Funabiki Yasuko,Nakata Masatoshi,Awaya Tomonari,Kato Takeo,Iida Kei,Okazaki Shin,Matsushima Kanae,Kato Toshihiro,Murai Toshiya,Heike Toshio,Geschwind Daniel H.,Hagiwara Masatoshi
Journal of Child Psychology and Psychiatry 60(5), 585-598, 2019-05
ウィリアムス症候群の多彩な症状が生じる仕組みを発見 --遺伝子発現ネットワークの異常に着目--. 京都大学プレスリリース. 2018-10-26.
NAID 120006533268

Impact of Body Mass Index of Japanese Gallbladder Cancer Patients on their Postoperative Outcomes

Fujii Masakuni,Fujimoto Kenji,Yabe Syuntaro,Nasu Junichiro,Miyaike Jiro,Yoshioka Masao,Shiode Junji,Yamamoto Kazuhide,Matsuda Shinya
Acta Medica Okayama 73(1), 51-59, 2019-02
… We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. …
NAID 120006559387