WordNet
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds
PrepTutorEJDIC
- 『頼っている』,依存している,従属している / 扶養される人(家族)
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- 1. 癌における悪液質の病因、臨床的特徴および評価 pathogenesis clinical features and assessment of cancer cachexia
- 2. ビタミンKおよびその合成ならびにガンマカルボキシグルタミン酸の機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
- 3. 黒色腫（メラノーマ）に対する遺伝的感受性 inherited susceptibility to melanoma
- 4. 稀な遺伝性凝固異常 rare inherited coagulation disorders
- 5. 緩和ケア：悪液質と食欲不振の評価および管理 palliative care assessment and management of anorexia and cachexia
English Journal
- Homology modeling and virtual screening of ubiquitin conjugation enzyme E2A for designing a novel selective antagonist against cancer.
- Ramatenki V1, Potlapally SR2, Dumpati RK1, Vadija R1, Vuruputuri U1.
- Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2015 Dec;35(6):536-49. doi: 10.3109/10799893.2014.969375. Epub 2015 Sep 4.
- Cancer is a major health problem in the world. The initiation and progression of cancer is due to imbalance between the programmed cell growth and death. These processes are triggered by the ubiquitin family enzymes. The ubiquitin-like proteins are responsible for the cell metabolism. Ubiquitin-depe
- PMID 25316404
- The N-terminal domains determine cellular localization and functions of the Doa4 and Ubp5 deubiquitinating enzymes.
- Wolters N1, Amerik A2.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 20;467(3):570-6. doi: 10.1016/j.bbrc.2015.09.136. Epub 2015 Sep 30.
- Ubiquitination is involved in numerous cellular regulatory mechanisms including the cell cycle, signal transduction and quality control. Ubiquitin modifies proteins by consecutive actions of ubiquitin-activating/conjugating enzymes. Attachment of ubiquitin is reversible. Deubiquitinating enzymes are
- PMID 26427873
- Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer.
- Yun SI1, Kim HH2, Yoon JH3, Park WS3, Hahn MJ1, Kim HC4, Chung CH5, Kim KK6.
- Molecular oncology.Mol Oncol.2015 Nov;9(9):1834-51. doi: 10.1016/j.molonc.2015.06.006. Epub 2015 Jul 3.
- β-catenin is a key signal transducer in the canonical WNT pathway and is negatively regulated by ubiquitin-dependent proteolysis. Through screening of various deubiquitinating enzymes (DUBs), we identified ubiquitin specific protease 4 (USP4) as a candidate for β-catenin-specific DUB. The effects
- PMID 26189775
Japanese Journal
- VHL病に伴う中枢神経系血管芽腫
- 中村 英夫,倉津 純一,執印 太郎
- 脳神経外科ジャーナル = Japanese journal of neurosurgery 22(1), 52-60, 2013-01-20
- Von Hippel-Lindau (VHL) 病は中枢神経系に血管芽腫が発生するだけでなく, 全身性に嚢胞や腫瘍が認められる疾患であり, 神経線維腫症と並んで脳神経外科医が携わる代表的な遺伝病である. 常染色体優性遺伝の形式をとり, 浸透率がほぼ100%であるVHL病は3番染色体上の腫瘍抑制遺伝子であるVHL遺伝子の異常が原因で起こるということが1993年に報告された. それ以来, VHL遺伝 …
- NAID 10031131676
- GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms.
- Kitagawa Kyoko,Kotake Yojiro,Hiramatsu Yoshihiro,Liu Ning,Suzuki Sayuri,Nakamura Satoki,Kikuchi Akira,Kitagawa Masatoshi
- 2010-11-21
- … The cellular level of c-Myb is controlled by not only transcriptional regulation but also ubiquitin-dependent proteolysis. … We recently reported that mouse c-Myb protein is controlled by ubiquitin-dependent degradation by SCF-Fbw7 E3 ligase via glycogen synthase kinase 3 (GSK3)-mediated phosphorylation of Thr-572 in a Cdc4 phosphodegron (CPD)-dependent manner. …
- NAID 120005305355
- F-Box Proteins That Contain Sugar-Binding Domains
- Bioscience, biotechnology, and biochemistry 71(11), 2623-2631, 2007-11-23
- … F-box proteins are the substrate-recognition subunits of the SCF (Skp1-Cul1-F-box protein) complex, which is the largest known class of E3 ubiquitin ligases. … They play important roles in ubiquitin-dependent proteolysis in eukaryotes. …
- NAID 10027520502
Related Links
- Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies. Sakamoto KM. Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children's Hospital, Jonsson Comprehensive ...
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★リンクテーブル★
| リンク元 | 「ubiquitin-mediated proteolysis」「ユビキチン依存性タンパク質分解」 |
| 関連記事 | 「proteolysis」「dependent」 |
「ubiquitin-mediated proteolysis」
「ユビキチン依存性タンパク質分解」
「proteolysis」
「dependent」
- adj.
- 依存性の、依存的な、依存型の、依存の