WordNet
- occupy an intermediate or middle position or form a connecting link or stage between two others; "mediate between the old and the new"
- acting through or dependent on an intervening agency; "the disease spread by mediate as well as direct contact"
- the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds
- acting or brought about through an intervening agency; "the mediated settlement brought satisfaction to both sides"
PrepTutorEJDIC
- 〈紛争・相違点など〉‘を'調停する,仲裁する / 〈妥協・和解・同意など〉‘を'仲裁して成立させる / (両者の)調停をする《+『between』+『名』》 / 仲介者(媒介物)を通じての,間接の
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- 1. 癌における悪液質の臨床的特徴および病因 clinical features and pathogenesis of cancer cachexia
- 2. 癌における食欲不振および悪液質の薬理学的マネージメント pharmacologic management of cancer anorexia cachexia
- 3. 末梢神経と筋肉に影響を与える腫瘍随伴性症候群 paraneoplastic syndromes affecting peripheral nerve and muscle
- 4. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
- 5. 輸血関連の免疫性および非免疫性溶血 transfusion associated immune and non immune mediated hemolysis
English Journal
- Fbw7α and fbw7γ collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation.
- Bhaskaran N, van Drogen F, Ng HF, Kumar R, Ekholm-Reed S, Peter M, Sangfelt O, Reed SI.SourceDepartment of Cell and Molecular Biology, The Karolinska Institute, Stockholm, Sweden.
- Molecular and cellular biology.Mol Cell Biol.2013 Jan;33(1):85-97. doi: 10.1128/MCB.00288-12. Epub 2012 Oct 29.
- Cyclin E1, an activator of cyclin-dependent kinase 2 (Cdk2) that promotes replicative functions, is normally expressed periodically within the mammalian cell cycle, peaking at the G(1)-S-phase transition. This periodicity is achieved by E2F-dependent transcription in late G(1) and early S phases and
- PMID 23109421
- Exome capture sequencing of adenoma reveals genetic alterations in multiple cellular pathways at the early stage of colorectal tumorigenesis.
- Zhou D, Yang L, Zheng L, Ge W, Li D, Zhang Y, Hu X, Gao Z, Xu J, Huang Y, Hu H, Zhang H, Zhang H, Liu M, Yang H, Zheng L, Zheng S.SourceThe Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, the Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China ; The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
- PloS one.PLoS One.2013;8(1):e53310. doi: 10.1371/journal.pone.0053310. Epub 2013 Jan 2.
- Most of colorectal adenocarcinomas are believed to arise from adenomas, which are premalignant lesions. Sequencing the whole exome of the adenoma will help identifying molecular biomarkers that can predict the occurrence of adenocarcinoma more precisely and help understanding the molecular pathways
- PMID 23301059
- The phosphatase-transcription activator EYA1 is targeted by APC/Cdh1 for degradation at M-to-G1 transition.
- Sun J, Karoulia Z, Wong EY, Ahmed M, Itoh K, Xu PX.SourceDepartment of Genetics and Genomic Sciences.
- Molecular and cellular biology.Mol Cell Biol.2012 Dec 21. [Epub ahead of print]
- The phosphatase and transactivator EYA family proteins are overexpressed in many cancer cell lines and are abundantly distributed in undifferentiated cells during development. Loss-of-function studies have shown that EYA1 is required for cell proliferation and survival during mammalian organogenesis
- PMID 23263983
Japanese Journal
- Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.
- The Journal of cell biology 204(5), 729-745, 2014-03-03
- NAID 120005385888
- Deregulation of Anaphase-promoting Complex/cyclosome-dependent Proteolysis in Cancer
- Journal of Oral Biosciences 52(4), 388-401, 2010
- NAID 130004475724
- 拡大するユビキチンの世界：基礎から病態へ
- 生物物理化学 51(2), 83-89, 2007
- NAID 130004456450
Related Links
- Ubiquitin-Mediated Proteolysis Ubiquitin is a highly conserved 76 amino acid protein capable of being covalently linked to lysine residues in protein targets. A cascade of enzymatic events that covalently tags substrates with ...
- Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a ...
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★リンクテーブル★
| リンク元 | 「ubiquitin-dependent proteolysis」「ユビキチン依存性タンパク質分解」 |
| 関連記事 | 「proteolysis」「mediate」 |
「ubiquitin-dependent proteolysis」
「ユビキチン依存性タンパク質分解」
「proteolysis」
「mediate」
- 仲介する、媒介する