ツーヒット機構
WordNet
- pay unsolicited and usually unwanted sexual attention to; "He tries to hit on women in bars"
- the act of contacting one thing with another; "repeated hitting raised a large bruise"; "after three misses she finally got a hit" (同)hitting, striking
- a conspicuous success; "that song was his first hit and marked the beginning of his career"; "that new Broadway show is a real smasher"; "the party went with a bang" (同)smash, smasher, strike, bang
- (baseball) a successful stroke in an athletic contest (especially in baseball); "he came all the way around on Williams hit"
- a connection made via the internet to another website; "WordNet gets many hits from users worldwide"
- a dose of a narcotic drug
- a murder carried out by an underworld syndicate; "it has all the earmarks of a Mafia hit"
- affect or afflict suddenly, usually adversely; "We were hit by really bad weather"; "He was stricken with cancer when he was still a teenager"; "The earthquake struck at midnight" (同)strike
- drive something violently into a location; "he hit his fist on the table"; "she struck her head on the low ceiling" (同)strike
- cause to experience suddenly; "Panic struck me"; "An interesting idea hit her"; "A thought came to me"; "The thought struck terror in our minds"; "They were struck with fear" (同)strike, come_to
- hit against; come into sudden contact with; "The car hit a tree"; "He struck the table with his elbow" (同)strike, impinge on, run_into, collide with
- cause to move by striking; "hit a ball"
- consume to excess; "hit the bottle"
- deal a blow to, either with the hand or with an instrument; "He hit her hard in the face"
- hit the intended target or goal
- the atomic process that occurs during a chemical reaction; "he determined unique mechanisms for the photochemical reactions" (同)chemical mechanism
- the technical aspects of doing something; "a mechanism of social control"; "mechanisms of communication"; "the mechanics of prose style" (同)mechanics
- device consisting of a piece of machinery; has moving parts that perform some function
- (philosophy) the philosophical theory that all phenomena can be explained in terms of physical or biological causes
- a natural object resembling a machine in structure or function; "the mechanism of the ear"; "the mechanism of infection"
- being one more than one; "he received two messages" (同)2, ii
- the cardinal number that is the sum of one and one or a numeral representing this number (同)2, II, deuce
PrepTutorEJDIC
- 〈人・物〉‘を'『打つ』,なぐる / …‘に'『ぶつかる』,衝突する / (…に)〈自分の体〉‘を'『ぶつける』《+『名』+『against』(『on』,『upon』)』+『名』》 / 《話》…‘に'達する / …‘に'ひどい打撃(結果)を与える / 《米》〈事が〉〈人〉‘に'ふと思い浮かぶ;〈人が〉…‘を'ふと見つける / (野球で)〈安打〉‘を'打つ;(クリケットで)〈…点〉‘を'取る / (武器などで)(…を)『打つ』,攻撃する《+『at』+『名』》 / (…に)『ぶつかる』,衝突する《+『against(on, upon)』+『名』》 / 襲う,急に現れる / 『打撃』,命中 / ヒット,大当たり,大成功 / (野球で)ヒット,安打(base hit) / 風刺,当てこすり
- 〈C〉機械;(部分的な)機械装置 / 〈C〉(機械装置に似た)機構 / 〈C〉(物事が行われる)仕組み,方法 / 〈U〉機械論
- 〈C〉(数の)『2』,2の記号 / 〈U〉2時,2分;2歳 / 《複数扱い》二人;2個 / 〈C〉二つ(二人,2個)1組のもの / 〈C〉(カードゲーム)2の札,(さいころの)2の目 / 2の;二人の;二つの,2個の / 《補語にのみ用いて》2歳の(で)
- 《話》(あいさつとして)『やあ』,こんにちは / 《英》(注意を促す発声として)おい,ちょっと(hey)
UpToDate Contents
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English Journal
- Mutation and catastrophe in the aging genome.
- Milholland B1, Suh Y2, Vijg J3.
- Experimental gerontology.Exp Gerontol.2017 Aug;94:34-40. doi: 10.1016/j.exger.2017.02.073. Epub 2017 Mar 2.
- PMID 28263867
- Effects of chronic forced-swim stress on behavioral properties in rats with neonatal repeated MK-801 treatment.
- Kawabe K1.
- Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2017 Aug;159:48-54. doi: 10.1016/j.pbb.2017.06.009. Epub 2017 Jun 21.
- PMID 28647564
- Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors.
- Kiwerska K1,2, Szaumkessel M3, Paczkowska J3, Bodnar M4,5, Byzia E3, Kowal E3, Kostrzewska-Poczekaj M3, Janiszewska J3, Bednarek K3, Jarmuż-Szymczak M3,6, Kalinowicz E5, Wierzbicka M5, Grenman R7, Szyfter K3,8, Marszałek A9, Giefing M3,5.
- Scientific reports.Sci Rep.2017 Jul 14;7(1):5386. doi: 10.1038/s41598-017-05857-1.
- PMID 28710449
Japanese Journal
- 高木 健治,石田 光明,岡部 英俊,野崎 和彦
- 脳神経外科ジャーナル = Japanese journal of neurosurgery 22(1), 28-36, 2013-01-20
- … Germline and somatic mutations may occur before cavernous malformations develop (two-hit mechanism). … Two patterns, with mulberry-like and hematoma-like appearances, are seen intraoperatively, and from histological findings, mulberry-like appearance may change into hematoma-like one by intralesional hemorrhage. …
- NAID 10031131673
- Mechanism of carcinogenesis in familial tumors
- TAMURA Kazuo,UTSUNOMIYA Joji,IWAMA Takeo,FURUYAMA Jun-ichi,TAKAGAWA Tetsuya,TAKEDA Naohisa,FUKUDA Yoshihiro,MATSUMOTO Takayuki,NISHIGAMI Takashi,KUSUHARA Kiyoshi,SAGAYAMA Ken,NAKAGAWA Kazuhiko,YAMAMURA Takehira
- International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology 9(4), 232-245, 2004-08-01
- NAID 10013569300
- 小林 敏之,百瀬 修二,足立 浩幸,三谷 弘明,小林 悦子,平山 榕子,樋野 興夫
- 日本疾患モデル学会記録 19, 38-42, 2003
- … Two causative genes for TSC. … Both genes act as tumor suppressors, and Knudson's two hit theory can be applied for the development of lesions in TSC. … However, activity of hamartin/tuberin complex and precise molecular mechanism undelying TSC disease remain to be determined.<BR>We identified a germline mutation of rat <I>TSC2</I> …
- NAID 130000760669
Related Links
- 1. Neurosurg Rev. 2013 Jul;36(3):483-6. doi: 10.1007/s10143-013-0456-z. Epub 2013 Apr 13. Two-hit mechanism in cerebral cavernous malformation? A case of monozygotic twins with a CCM1/KRIT1 germline mutation.
- 'Two-Hit' Hypothesis Much of what scientists know about the origins of cancer and the role of tumor suppressors can be traced back 28 years to the elegant theory of cancer researcher Alfred G. Knudson. Widely thought ...
★リンクテーブル★
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- 英
- two-hit mechanism
- 関
- ヘテロ接合性欠損
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- 関
- beat、strike
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ヘパリン起因性血小板減少症 heparin-induced thrombocytopenia
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