WordNet

matter that remains after something has been removed
an amino acid that occurs in proteins; is essential for growth and normal metabolism; a precursor of niacin (同)tryptophane

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Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH.
Biochimica et biophysica acta. Molecular cell research. 2019 Jul;1866(7)1189-1196.
The NAD-glycohydrolase/ADP-ribosyl cyclase CD38 catalyzes the metabolism of nicotinamide adenine dinucleotide (NAD) to the Ca mobilizing second messengers ADP-ribose (ADPR), 2'-deoxy-ADPR, and cyclic ADP-ribose (cADPR). In the present study, we investigated binding and metabolism of NAD by a soluble
PMID 30472140

C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.

Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N, Simizu S.
International journal of oncology. 2019 Jun;54(6)2127-2138.
R‑spondin2 (Rspo2), one of the four members of the R‑spondin family of proteins, has agonistic activity in the Wnt/β‑catenin signaling pathway, and it is associated with normal development, as well as disease, such as cancer. The present study focused on the C‑mannosylation of Rspo2, which
PMID 30942431

Interaction of a macrocycle with an aggregation-prone region of a monoclonal antibody.

Martinez Morales M, Zalar M, Sonzini S, Golovanov AP, van der Walle CF, Derrick JP.
Molecular pharmaceutics. 2019 May;().
Colloidal stability is among the key challenges the pharmaceutical industry faces during production and manufacturing of protein therapeutics. Self-association and aggregation processes can not only impair therapeutic efficacy but also induce immunogenic responses in patients. Aggregation-prone regi
PMID 31088082

Role of Tryptophan Residues in a Class V Chitinase from <I>Nicotiana tabacum</I>

UMEMOTO Naoyuki,OHNUMA Takayuki,URPILAINEN Henri,YAMAMOTO Takanori,NUMATA Tomoyuki,FUKAMIZO Tamo
Bioscience, Biotechnology, and Biochemistry 76(4), 778-784, 2012
… Tryptophan residues located in the substrate-binding cleft of a class V chitinase from <I>Nicotiana tabacum</I> … The strong effects of the Trp326 mutations on activity and stability suggest multiple roles of the residue in stabilizing the protein structure, in sugar residue binding at subsite −2, and probably in maintaining catalytic efficiency by providing a hydrophobic environment for proton donor Glu115. …
NAID 130001862889

森下文浩,古川康雄,松島治
比較生理生化学 28(4), 308-316, 2011-12-20
　動物の恒常性や行動の調節において重要な役割を担う神経ペプチドやペプチドホルモンの中には，特定のアミノ酸残基がＤ型化しているものがある。これらのペプチドは，元々，全てＬ型アミノ酸を用いて生合成され，翻訳後修飾の過程でイソメラーゼによりＤ型化される。われわれは，アメフラシから強力な心拍動増強作用をもつ３残基ペプチド，NdWFamide（NdWFa）を同定した。このペプチドは，その名の通り，Asn-T …
NAID 10030754322

OKADA Masahiro
Bioscience, biotechnology, and biochemistry 75(8), 1413-1417, 2011-08-23
… The ComX pheromones are formed by geranylation or farnesylation on a tryptophan residue at the 3 position of its indole ring. … The ComX pheromone is the first example of isoprenoidal modifiations of tryptophan residues in living organisms and post-translational isoprenylation of any amino acid in prokaryotes. …
NAID 10029590897