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prolonged spasm of the jaw muscles

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/18 20:44:10」(JST)

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Trismus, or lockjaw, refers to reduced opening of the jaws caused by spasm of the muscles of mastication, or may generally refer to all causes of limited mouth opening.^[1] It is a common problem with a variety of causes, and may interfere with eating, speech, oral hygiene, and could alter facial appearance. There is an increased risk of aspiration. Temporary trismus is much more common than permanent trismus,^[2] and may be distressing and painful, and limit or prevent medical examination or treatments requiring access to the oral cavity.

1 Definition
2 Differential diagnosis
- 2.1 Joint problems
  - 2.1.1 Ankylosis
  - 2.1.2 Arthritis synovitis
  - 2.1.3 Meniscus pathology
- 2.2 Extra-articular causes
  - 2.2.1 Infection
  - 2.2.2 Dental treatment
  - 2.2.3 Trauma
  - 2.2.4 TMJ disorders
  - 2.2.5 Tumors and oral care
  - 2.2.6 Drug therapy
  - 2.2.7 Radiotherapy and chemotherapy
  - 2.2.8 Congenital and developmental causes
  - 2.2.9 Miscellaneous disorders
- 2.3 Common causes
- 2.4 Other causes
3 Diagnostic approach
4 Treatment
5 History
6 References

Definition

Classically, the definition of trismus is an inability to open the mouth due to muscular spasm, but more generally it refers to limited mouth opening of any cause.^[3] Another definition of trismus is simply a limitation of movement.^[2] Historically and commonly, the term lock jaw was sometimes used as a synonym for both trismus and tetanus. Definitions from popular medical dictionaries vary, e.g.:

"a motor disturbance of the trigeminal nerve, especially spasm of the masticatory muscles, with difficulty in opening the mouth (lockjaw); a characteristic early symptom of tetanus."

"a firm closing of the jaw due to tonic spasm of the muscles of mastication from disease of the motor branch of the trigeminal nerve. It is usually associated with general tetanus. Also called lockjaw."

"a prolonged tonic spasm of the muscles of the jaw."

"spasms of the muscles of mastication resulting in the inability to open the oral cavity; often symptomatic of pericoronitis."^[4]

Normal mouth opening ranges from 35 to 45 mm.^[3] Males usually have slightly greater mouth opening than females. (40-60mm)=(avg-35mm). The Normal Lateral movement is (8-12mm).^[5] Some have distinguished mild trismus as 20–30 mm interincisal opening, moderate as 10–20 mm and severe as less than 10 mm.^[6]

Trismus is derived from the Greek word trismos meaning "a scream; a grinding, rasping or gnashing"^[7]

Differential diagnosis

Traditionally causes of trismus are divided into intra-articular (factors within the temporomandibular joint [TMJ]) and extra-articular (factors outside the joint, see table).^[2]

Commonly listed causes of trismus

Intra-articular:

Internal derangement of TMJ / meniscus displacement.^[1]^[3]
Fractured mandibular condyle or intracapsular fracture.^[1]
TMJ dislocation.^[2]
Traumatic synovitis.^[1]
Septic arthritis.^[3]
Osteoarthritis.^[1]
Inflammatory arthritis (e.g. rheumatoid or psoriatic).^[1]
Ankylosis.^[1]
Osteophyte formation.^[3]

Extra-articular:

Trauma not involving the mandibular condyle (e.g. a fracture of another part of the mandible, fractures of the middle third of the facial skeleton, fractures of the zygoma or zygomatic arch).^[1]
Post surgical edema, e.g. removal of impacted lower wisdom teeth,^[1] or other dentoalveolar surgery.^[3]
Recent prolonged dental treatment (e.g. root canal therapy).^[1]
Following administration of inferior alveolar nerve block with local anesthetic (medial pterygoid).^[3]
Hematoma of medial pterygoid.^[2]
Acute infections of the oral tissues, especially involving the buccal space or muscles of mastication.^[1]
- Odontogenic infection.^[1]^[3]
- Peritonsillar abscess.^[3]
- Acute parotitis, e.g. mumps.^[2]
- Pericoronitis.^[2]
- Submasseteric abscess.^[2]
Tetanus.^[2]^[3]
Tetany.^[2]
Local malignancy.^[3]
Myofascial pain / temporomandibular joint dysfunction.^[3]
Radiation fibrosis.^[3]
Fibrosis from burns.^[2]
Submucous fibrosis.^[3]
Systemic sclerosis.^[8]
Myositis ossificans.^[8]
Coronoid hyperplasia.^[3]
Malignant hyperpyrexia.^[3]
Epidermolysis bullosa.^[5]
Drug associated dyskinesia.^[2]
Psychotic disturbances, hysteria.^[2]

Joint problems

Ankylosis

True bony ankylosis: can result from trauma to chin, infections and from prolonged immobilization following condylar fracture
- Treatment – several surgical procedures are used to treat bony ankylosis, e.g.: Gap arthroplasty using interpositional materials between the cut segments.
Fibrous ankylosis: usually results due to trauma and infection
- Treatment – trismus appliances in conjunction with physical therapy.

Arthritis synovitis

Meniscus pathology

Extra-articular causes

Infection

Odontogenic- Pulpal
- Periodontal
- Pericoronal
Non-odontogenic- Peritonsillar abscess
- Tetanus
- Meningitis
- Brain abscess
- Parotid abscess
The hallmark of a masticatory space infection is trismus or infection in anterior compartment of lateral pharyngeal space results in trismus. If these infections are unchecked, can spread to various facial spaces of the head and neck and lead to serious complications such as cervical cellulitis or mediastinitis.
- Treatment: Elimination of etiologic agent along with antibiotic coverage
Trismus or lock jaw due to masseter muscle spasm, can be a primary presenting symptom in tetanus, Caused by clostridium tetani, where tetanospasmin (toxin) is responsible for muscle spasms.
- Prevention: primary immunization (DPT)

Dental treatment

Dental trismus is characterized by a difficulty in opening the jaw. It is a temporary condition with a duration usually not longer than two weeks. Dental trismus results from some sort of insult to the muscles of mastication, such as opening the jaw for a period of time or having a needle pass through a muscle. Typical dental anesthesia to the lower jaw often involves the needle passing into or through a muscle. In these cases it is usually the medial pterygoid or the buccinator muscles.
Oral surgery procedures, as in the extraction of lower molar teeth, may cause trismus as a result either of inflammation to the muscles of mastication or direct trauma to the TMJ.
Barbing of needles at the time of injection followed by tissue damage on withdrawal of the barbed needle causes post-injection persistent paresthesia, trismus and paresis.
- Treatment: in acute phase:
  - Heat therapy
  - Analgesics
  - A soft diet
  - Muscle relaxants (if necessary)
  - Note: When acute phase is over the patient should be advised to initiate physiotherapy for opening and closing mouth.

Trauma

Fractures, particularly those of the mandible and fractures of zygomatic arch and zygomatic arch complex, accidental incorporation of foreign bodies due to external traumatic injury. Treatment: fracture reduction, removal of foreign bodies with antibiotic coverage

TMJ disorders

Extra-capsular disorders – Myofascial Pain Dysfunction Syndrome
Intra-capsular problems – Disc displacement, arthritis, fibrosis, etc.
Acute closed locked conditions – displaced meniscus

Tumors and oral care

Rarely, trismus is a symptom of nasopharyngeal or infratemporal tumors/ fibrosis of temporalis tendon, when patient has limited mouth opening, always premalignant conditions like oral submucous fibrosis (OSMF) should also be considered in differential diagnosis.

Drug therapy

Succinyl choline, phenothiazines and tricyclic antidepressants causes trismus as a secondary effect. Trismus can be seen as an extra-pyramidal side-effect of metaclopromide, phenothiazines and other medications.

Radiotherapy and chemotherapy

Complications of radiotherapy:
- Osteoradionecrosis may result in pain, trismus, suppuration and occasionally a foul smelling wound.
- When muscles of mastication are within the field of radiation, it leads to fibrosis and result in decreased mouth opening.
Complications of Chemotherapy:
- Oral mucosal cells have high growth rate and are susceptible to the toxic effects of chemotherapy, which lead to stomatitis.

Congenital and developmental causes

Hypertrophy of coronoid process causes interference of coronoid against the anteromedial margin of the zygomatic arch.
- Treatment: Coronoidectomy
Trismus-pseudo-camtodactyly syndrome is a rare combination of hand, foot and mouth abnormalities and trismus.

Miscellaneous disorders

Hysteric patients: Through the mechanisms of conversion, the emotional conflict are converted into a physical symptom. E.g.: trismus
Scleroderma: A condition marked by edema and induration of the skin involving facial region can cause trismus

Common causes

Lock-jaw caused due to muscle rigidity.

Pericoronitis (inflammation of soft tissue around impacted third molar) is the most common cause of trismus.^[9]
Inflammation of muscles of mastication.^[9] It is a frequent sequel to surgical removal of mandibular third molars (lower wisdom teeth). The condition is usually resolved on its own in 10–14 days, during which time eating and oral hygiene are compromised. The application of heat (e.g. heat bag extraorally, and warm salt water intraorally) may help, reducing the severity and duration of the condition.
Peritonsillar abscess,^[9] a complication of tonsillitis which usually presents with sore throat, dysphagia, fever, and change in voice.
Temporomandibular joint dysfunction (TMD).^[9]
Trismus is often mistaken as a common temporary side effect of many stimulants of the sympathetic nervous system. Users of amphetamines as well as many other pharmacological agents commonly report bruxism as a side-effect; however, it is sometimes mis-referred to as trismus. Users' jaws do not lock, but rather the muscles become tight and the jaw clenched. It is still perfectly possible to open the mouth.^[9]
Submucous fibrosis.
Fracture of the zygomatic arch.

Other causes

Acute osteomyelitis
Ankylosis of the TMJ (fibrous or bony)
Condylar fracture or other trauma.
Gaucher disease which is caused by deficiency of the enzyme glucocerebrosidase.
Giant cell arteritis
Infection
Local anesthesia (dental injections into the infratemporal fossa)
Needle prick to the medial pterygoid muscle
Oral submucous fibrosis.
Radiation therapy to the head and neck.
Tetanus, also called lockjaw for this reason
Malignant hyperthermia
Malaria severa
Secondary to neuroleptic drug use
Malignant otitis externa
Mumps
Peritonsillar abscess
Retropharyngeal or parapharyngeal abscess
Seizure
Stroke

Diagnostic approach

X-ray/CT scan taken from the TMJ to see if there is any damage to the TMJ and surrounding structures.

Treatment

Treatment requires treating the underlying condition with dental treatments, physical therapy, and passive range of motion devices. Additionally, control of symptoms with pain medications (NSAIDs), muscle relaxants, and warm compresses may be used.

Splints have been used.^[10]

History

Historically, the term trismus was used to describe the early effects of tetany, also called "lock jaw".

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Odell, edited by Edward W. (2010). Clinical problem solving in dentistry (3rd ed.). Edinburgh: Churchill Livingstone. pp. 37–41. ISBN 9780443067846.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Soames, J.V.; Southam, J.C. (1998). Oral pathology (3rd ed.). Oxford: Oxford University Press. p. 330. ISBN 019262895X.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p Newlands, edited by Cyrus Kerawala, Carrie (2010). Oral and maxillofacial surgery. Oxford: Oxford University Press. ISBN 9780199204830.
^ "Definitions of "Trismus" on The Free Online Dictionary by Farlex". Farlex, Inc. Retrieved 11 February 2013.
^ ^a ^b Scully, Crispian (2008). Oral and maxillofacial medicine : the basis of diagnosis and treatment (2nd ed.). Edinburgh: Churchill Livingstone. pp. 101, 353. ISBN 9780443068188.
^ Hupp JR, Ellis E, Tucker MR (2008). Contemporary oral and maxillofacial surgery (5th ed.). St. Louis, Mo.: Mosby Elsevier. ISBN 9780323049030.
^ "Etymology of Trismus on Online Etymology Dictionary". Douglas Harper. Retrieved 10 February 2013.
^ ^a ^b Kalantzis, Crispian Scully, Athanasios (2005). Oxford handbook of dental patient care (2nd ed.). New York: Oxford University Press. ISBN 9780198566236.
^ ^a ^b ^c ^d ^e Chris. "Dr.". Locked Jaw (Lockjaw and Slack Jaw) Meaning and Causes |. Healthhype.com. Retrieved 13 September 2012.
^ Shulman DH, Shipman B, Willis FB (2008). "Treating trismus with dynamic splinting: A cohort, case series". Adv Ther 25 (1): 9–16. doi:10.1007/s12325-008-0007-0. PMID 18227979.

UpToDate Contents

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1. 破傷風 tetanus
2. 頭頚部癌の後期合併症のマネージメントおよびその治療 management of late complications of head and neck cancer and its treatment
3. 下顎関節（TMJ）脱臼の整復 reduction of temporomandibular joint tmj dislocation
4. 扁桃の蜂巣炎および膿瘍 peritonsillar cellulitis and abscess
5. 頭頚部癌の長期生存者に対するアプローチの概要 overview of approach to long term survivors of head and neck cancer

English Journal

Reconstruction with fibular osteocutaneous free flap in patients with mandibular osteoradionecrosis.

Kim MG1, Lee ST1, Park JY1, Choi SW1.
Maxillofacial plastic and reconstructive surgery.Maxillofac Plast Reconstr Surg.2015 Feb 5;37(1):7. eCollection 2015.
BACKGROUND: Osteoradionecrosis is a delayed complication from radiation therapy which causes chronic pain, infection and constant deformity after necrosis. Most of the osteoradionecrosis occurs spontaneously or after the primary oncologic surgery, dental extraction or by trauma of prosthesis. The tr
PMID 25685753

A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120mg on inflammatory events following removal of unerupted mandibular third molars.

Costa FW1, Soares EC2, Esses DF3, Silva PG3, Bezerra TP4, Scarparo HC5, Ribeiro TR6, Fonteles CS7.
International journal of oral and maxillofacial surgery.Int J Oral Maxillofac Surg.2015 Sep;44(9):1166-74. doi: 10.1016/j.ijom.2015.06.012. Epub 2015 Jul 3.
Pain after third molar extraction has been considered the most suitable pharmaceutical model to evaluate acute pain. This study aimed to evaluate the pre-emptive analgesic/anti-inflammatory efficacy of etoricoxib 120mg following mandibular third molar surgery. A split-mouth, randomized, triple-blind
PMID 26144571

Botulinum toxin in masticatory muscles of the adult rat induces bone loss at the condyle and alveolar regions of the mandible associated with a bone proliferation at a muscle enthesis.

Kün-Darbois JD1, Libouban H2, Chappard D3.
Bone.Bone.2015 Aug;77:75-82. doi: 10.1016/j.bone.2015.03.023. Epub 2015 Apr 7.
In man, botulinum toxin type A (BTX) is injected in masticatory muscles for several indications such as trismus, bruxism, or masseter hypertrophy. Bone changes in the mandible following BTX injections in adult animal have therefore became a subject of interest. The aim of this study was to analyze c
PMID 25857689

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