- ・訳産物
WordNet
- a chemical substance formed as a result of a chemical reaction; "a product of lime and nitric acid"
- a consequence of someones efforts or of a particular set of circumstances; "skill is the product of hours of practice"; "his reaction was the product of hunger and fatigue"
- an artifact that has been created by someone or some process; "they improve their product every year"; "they export most of their agricultural production" (同)production
- a quantity obtained by multiplication; "the product of 2 and 3 is 6" (同)mathematical product
- (genetics) the process whereby genetic information coded in messenger RNA directs the formation of a specific protein at a ribosome in the cytoplasm
- (mathematics) a transformation in which the origin of the coordinate system is moved to another position but the direction of each axis remains the same
- the act of uniform movement (同)displacement
- a written communication in a second language having the same meaning as the written communication in a first language (同)interlingual rendition, rendering, version
- a uniform movement without rotation
- rewording something in less technical terminology
PrepTutorEJDIC
- 『産物』;製品 / (…の)結果,帰結《+『of』+『名』(do『ing』)》 / (数の)積 / (化学の)生成物
- 〈U〉『訳すこと,翻訳』 / 〈C〉翻訳されたもの
UpToDate Contents
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- 1. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
- 2. 胃腸ペプチドの合成、分泌、および調節 synthesis secretion and regulation of gastrointestinal peptides
- 3. エンテロウイルスおよびパレコウイルス感染症の疫学、病因、治療、および予防 epidemiology pathogenesis treatment and prevention of enterovirus and parechovirus infections
- 4. von Willebrand因子の生物学および正常機能 biology and normal function of von willebrand factor
- 5. インスリン受容体の構造および機能 structure and function of the insulin receptor
English Journal
- The translation elongation factor eEF2 is a novel tumor‑associated antigen overexpressed in various types of cancers.
- Oji Y1, Tatsumi N1, Fukuda M2, Nakatsuka S3, Aoyagi S2, Hirata E2, Nanchi I2, Fujiki F4, Nakajima H4, Yamamoto Y2, Shibata S2, Nakamura M2, Hasegawa K1, Takagi S2, Fukuda I2, Hoshikawa T2, Murakami Y2, Mori M5, Inoue M6, Naka T7, Tomonaga T8, Shimizu Y9, Nakagawa M10, Hasegawa J11, Nezu R11, Inohara H12, Izumoto S13, Nonomura N14, Yoshimine T13, Okumura M6, Morii E15, Maeda H16, Nishida S17, Hosen N18, Tsuboi A17, Oka Y7, Sugiyama H2.Author information 1Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan.2Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan.3Department of Pathology, Kansai Rosai Hospital, Hyogo, Japan.4Department of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.5Department of Thoracic Oncology, Toneyama National Hospital, Osaka, Japan.6Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.7Department of Respiratory Medicine and Allergy, Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan.8Laboratory of Proteome Research, National Institute of Biomedical Innovation, Osaka, Japan.9Department of Internal Medicine, Takarazuka City Hospital, Hyogo, Japan.10Department of Internal Medicine, Nissay Hospital, Osaka, Japan.11Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.12Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.13Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.14Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.15Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.16Department of General Thoracic Surgery, Toneyama National Hospital, Osaka, Japan.17Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.18Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Osaka, Japan.AbstractRecent studies have shown that cancer immunotherapy could be a promising therapeutic approach for the treatment of cancer. In the present study, to identify novel tumor-associated antigens (TAAs), the proteins expressed in a panel of cancer cells were serologically screened by immunoblot analysis and the eukaryotic elongation factor 2 (eEF2) was identified as an antigen that was recognized by IgG autoantibody in sera from a group of patients with head and neck squamous cell carcinoma (HNSCC) or colon cancer. Enzyme-linked immunosorbent assay showed that serum eEF2 IgG Ab levels were significantly higher in colorectal and gastric cancer patients compared to healthy individuals. Immunohistochemistry experiments showed that the eEF2 protein was overexpressed in the majority of lung, esophageal, pancreatic, breast and prostate cancers, HNSCC, glioblastoma multiforme and non-Hodgkin's lymphoma (NHL). Knockdown of eEF2 by short hairpin RNA (shRNA) significantly inhibited the growth in four eEF2-expressing cell lines, PC14 lung cancer, PCI6 pancreatic cancer, HT1080 fibrosarcoma and A172 glioblastoma cells, but not in eEF2-undetectable MCF7 cells. Furthermore, eEF2-derived 9-mer peptides, EF786 (eEF2 786-794 aa) and EF292 (eEF2 292-300 aa), elicited cytotoxic T lymphocyte (CTL) responses in peripheral blood mononuclear cells (PBMCs) from an HLA-A*24:02- and an HLA-A*02:01-positive healthy donor, respectively, in an HLA-A-restricted manner. These results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth. Moreover, the eEF2 gene product is immunogenic and a promising target molecule of cancer immunotherapy for several types of cancers.
- International journal of oncology.Int J Oncol.2014 May;44(5):1461-9. doi: 10.3892/ijo.2014.2318. Epub 2014 Mar 4.
- Recent studies have shown that cancer immunotherapy could be a promising therapeutic approach for the treatment of cancer. In the present study, to identify novel tumor-associated antigens (TAAs), the proteins expressed in a panel of cancer cells were serologically screened by immunoblot analysis an
- PMID 24589652
- A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae.
- Samanfar B1, Tan le H, Shostak K, Chalabian F, Wu Z, Alamgir M, Sunba N, Burnside D, Omidi K, Hooshyar M, Galván Márquez I, Jessulat M, Smith ML, Babu M, Azizi A, Golshani A.Author information 1Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada. ashkan_golshani@carleton.ca.AbstractProtein biosynthesis is an orderly process that requires a balance between rate and accuracy. To produce a functional product, the fidelity of this process has to be maintained from start to finish. In order to systematically identify genes that affect stop codon bypass, three expression plasmids, pUKC817, pUKC818 and pUKC819, were integrated into the yeast non-essential loss-of-function gene array (5000 strains). These plasmids contain three different premature stop codons (UAA, UGA and UAG, respectively) within the LacZ expression cassette. A fourth plasmid, pUKC815 that carries the native LacZ gene was used as a control. Transformed strains were subjected to large-scale β-galactosidase lift assay analysis to evaluate production of β-galactosidase for each gene deletion strain. In this way 84 potential candidate genes that affect stop codon bypass were identified. Three candidate genes, OLA1, BSC2, and YNL040W, were further investigated, and were found to be important for cytoplasmic protein biosynthesis.
- Molecular bioSystems.Mol Biosyst.2014 Apr 4;10(4):916-24. doi: 10.1039/c3mb70501c. Epub 2014 Feb 18.
- Protein biosynthesis is an orderly process that requires a balance between rate and accuracy. To produce a functional product, the fidelity of this process has to be maintained from start to finish. In order to systematically identify genes that affect stop codon bypass, three expression plasmids, p
- PMID 24535059
- Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase.
- Sun Y1, Wang Z1, Tao J1, Wang Y1, Wu A1, Yang Z2, Wang K2, Shi L2, Chen Y3, Guo D4.Author information 1State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China.2Biological Pesticide Engineering Research Center, Hubei Academy of Agricultural Science, Hubei 430072, PR China.3State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China. Electronic address: chenyu@whu.edu.cn.4State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China. Electronic address: dguo@whu.edu.cn.AbstractThe 5'-cap structure is a distinct feature of eukaryotic mRNAs and is important for RNA stability and protein translation by providing a molecular signature for the distinction of self or non-self mRNA. Eukaryotic viruses generally modify the 5'-end of their RNAs to mimic the cellular mRNA structure, thereby facilitating viral replication in host cells. However, the molecular organization and biochemical mechanisms of the viral capping apparatus typically differ from its cellular counterpart, which makes viral capping enzymes attractive targets for drug discovery. Our previous work showed that SARS coronavirus (SARS-CoV) non-structural protein 14 represents a structurally novel and unique guanine-N7-methyltransferase (N7-MTase) that is able to functionally complement yeast cellular N7-MTase. In the present study, we developed a yeast-based system for identifying and screening inhibitors against coronavirus N7-MTase using both 96-well and 384-well microtiter plates. The MTase inhibitors previously identified by in vitro biochemical assays were tested, and some, such as sinefungin, effectively suppressed N7-MTase in the yeast system. However, other compounds, such as ATA and AdoHcy, did not exert an inhibitory effect within a cellular context. These results validated the yeast assay system for inhibitor screening yet also demonstrated the difference between cell-based and in vitro biochemical assays. The yeast system was applied to the screening of 3000 natural product extracts, and three were observed to more potently inhibit the activity of coronavirus than human N7-MTase.
- Antiviral research.Antiviral Res.2014 Apr;104:156-64. doi: 10.1016/j.antiviral.2014.02.002. Epub 2014 Feb 11.
- The 5'-cap structure is a distinct feature of eukaryotic mRNAs and is important for RNA stability and protein translation by providing a molecular signature for the distinction of self or non-self mRNA. Eukaryotic viruses generally modify the 5'-end of their RNAs to mimic the cellular mRNA structure
- PMID 24530452
Japanese Journal
- Largen: A Molecular Regulator of Mammalian Cell Size Control
- Yamamoto Kazuo,Gandin Valentina,Sasaki Masato,McCracken Susan,Li Wanda,Silvester Jennifer Liepa,Elia Andrew J.,Wang Feng,Wakutani Yosuke,Alexandrova Roumiana,Oo Yathor D,Mullen Peter J.,Inoue Satoshi,Itsumi Momoe,Lapin Valentina,Haight Jillian,Wakeham Andrew,Shahinian Arda,Ikura Mitsuhiko,Topisirovic Ivan,Sonenberg Nahum,Mak Tak W.
- Molecular Cell 53(6), 904-915, 2014-03-20
- … We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. … Invitro evidence indicated that Largen preferentially stimulates the translation of specific subsetsof mRNAs, including those encoding proteins affecting mitochondrial functions. …
- NAID 120005438951
- 韓流フォーエバー -世界は韓流スタイル-
- 佐々木 正徳
- 長崎外大論叢 (17), 189-201, 2013-12-30
- … This paper comprises a translation of the "prologue" of Hallyu Forever - Hallyu Style in the World', a publication issued by KOFICE (the Korea Foundation for International Culture Exchange). … Economic benefits appear to be construed as a product of national brand competitiveness, a perception which can be confirmed by reading the prologue translated in this paper. …
- NAID 110009759103
- スマートフォンが要求する超低背カメラモジュール : カメラモジュールの超低背化を実現するための要素技術(イメージセンサ,カメラ信号処理,画像評価関連技術,及び2013IISWとVLSIシンポジウムからの発表報告)
- 中條 博則
- 映像情報メディア学会技術報告 37(40), 49-54, 2013-09-23
- ハードキーがほとんどなく,タッチパネルによるUIのシンプルなデザインのスマートフォンが世界市場で急増している.そして、その市場が本格化する中,外観の差異化を図るため薄型,フルフラットデザインがトレンドとなっており,その影響から内部の部品も低背化が強く求められている,光学設計上適切な空間距離を必要とするカメラモジュールもその例外ではない.常識的な設計手法では良好な光学特性の確保が難しいレベルの低背化 …
- NAID 110009662106
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Related Pictures
★リンクテーブル★
| リンク元 | 「翻訳産物」「gene product」 |
| 関連記事 | 「product」「translation」 |
「翻訳産物」
「gene product」
- 遺伝子産物、・訳産物
「product」
- n.
「translation」
- n.