トランスフェリン飽和度
WordNet
- a condition in which a quantity no longer responds to some external influence
- chromatic purity: freedom from dilution with white and hence vivid in hue (同)chroma, intensity, vividness
- the act of soaking thoroughly with a liquid
- a globulin in blood plasma that carries iron (同)beta_globulin, siderophilin
PrepTutorEJDIC
- 十分にしみ込むこと,飽和させること / しみ込んだ状態,飽和状態 / (色の)飽和度,彩度
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/05 06:48:49」(JST)
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This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
Transferrin saturation, abbreviated as TSAT and measured as a percentage, is a medical laboratory value. It is the ratio of serum iron and total iron-binding capacity, multiplied by 100. Of the transferrin that is available to bind iron, this value tells a clinician how much serum iron is actually bound. For instance, a value of 15% means that 15% of iron-binding sites of transferrin is being occupied by iron. For an explanation of some clinical situations in which this ratio is important, see Total iron-binding capacity. The three results are usually reported together.
Usual values
Normal reference ranges are:
- Serum iron: 60–170 μg/dl (10–30μmol/L)
- TIBC: 240–450 μg/dl
- Transferrin saturation: 15–50% (males), 12–45% (females)
μg/dl = micrograms per deciliter.
Laboratories often use different units and "normal" may vary by population and the lab techniques used. Look at the individual laboratory reference values to interpret a specific test (for instance, your own).
Reference ranges for blood tests, comparing blood content of iron and related compounds (shown in brown and orange) with other constituents.
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Pathology: hematology, hematologic diseases of RBCs and megakaryocytes / MEP (D50-69,74, 280-287)
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Red
blood cells |
| ↑ |
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| ↓ |
| Anemia |
| Nutritional |
- Micro-: Iron deficiency anemia
- Macro-: Megaloblastic anemia
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Hemolytic
(mostly Normo-) |
| Hereditary |
- enzymopathy: G6PD
- glycolysis
- hemoglobinopathy: Thalassemia
- Sickle-cell disease/trait
- HPFH
- membrane: Hereditary spherocytosis
- Minkowski-Chauffard syndrome
- Hereditary elliptocytosis
- Southeast Asian ovalocytosis
- Hereditary stomatocytosis
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| Acquired |
- Drug-induced autoimmune
- Drug-induced nonautoimmune
- Hemolytic disease of the newborn
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Aplastic
(mostly Normo-) |
- Hereditary: Fanconi anemia
- Diamond–Blackfan anemia
- Acquired: PRCA
- Sideroblastic anemia
- Myelophthisic
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| Blood tests |
- MCV
- Normocytic
- Microcytic
- Macrocytic
- MCHC
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| Other |
- Methemoglobinemia
- Sulfhemoglobinemia
- Reticulocytopenia
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Coagulation/
coagulopathy |
| ↑ |
Hyper-
coagulability |
- primary: Antithrombin III deficiency
- Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden
- Prothrombin G20210A
- Sticky platelet syndrome
- acquired:Thrombocytosis
- DIC
- Congenital afibrinogenemia
- Purpura fulminans
- autoimmune
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| ↓ |
Hypo-
coagulability |
| Thrombocytopenia |
- Thrombocytopenic purpura: ITP
- TM
- Heparin-induced thrombocytopenia
- May-Hegglin anomaly
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| Platelet function |
- adhesion
- aggregation
- Glanzmann's thrombasthenia
- platelet storage pool deficiency
- Hermansky–Pudlak syndrome
- Gray platelet syndrome
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| Clotting factor |
- Hemophilia
- von Willebrand disease
- Hypoprothrombinemia/II
- XIII
- Dysfibrinogenemia
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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Medical test: Serology, reference range: Clinical biochemistry blood tests (including BMP, CMP) (CPT 82000–84999)
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| Fluid/electrolytes |
- electrolytes
- renal function, BUN-to-creatinine ratio
- Ca
- derived values: Plasma osmolality
- Serum osmolal gap
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| Acid-base |
- Arterial blood gas
- Base excess
- Anion gap
- CO2 content
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| Nutrition |
- Iron tests: Transferrin saturation = Serum iron / Total iron-binding capacity; Ferritin
- Transferrin
- Transferrin receptor
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| Endocrine |
- ACTH stimulation test
- Thyroid function tests
- Blood sugar: Glucose test
- C-peptide
- Fructosamine
- Glycated hemoglobin
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| Metabolic |
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| Cardiovascular |
- Cardiac marker: Troponin test
- CPK-MB test
- LDH
- Myoglobin
- Glycogen phosphorylase isoenzyme BB
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| Digestive |
- Liver function tests: protein tests
- Human serum albumin
- Serum total protein
- ALP
- transaminases
- Bilirubin
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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noco (d)/cong/tumr, sysi/epon
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proc, drug (A10/H1/H2/H3/H5)
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noco/cong/tumr, sysi/epon, injr
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proc, drug (C1A/1B/1C/1D), blte
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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UpToDate Contents
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English Journal
- Fe and Cu do not differ in Parkinson's disease: A replication study plus meta-analysis.
- Mariani S, Ventriglia M, Simonelli I, Donno S, Bucossi S, Vernieri F, Melgari JM, Pasqualetti P, Rossini PM, Squitti R.SourceDepartment of Neurology, "Campus Bio-Medico" University, Rome, Italy. Electronic address: s.mariani@unicampus.it.
- Neurobiology of aging.Neurobiol Aging.2013 Feb;34(2):632-3. doi: 10.1016/j.neurobiolaging.2012.05.015. Epub 2012 Jun 26.
- To evaluate whether iron and copper levels in serum, plasma, and cerebrospinal fluid are disarranged in Parkinson's disease (PD), we performed meta-analyses of 33 studies on the topic published from 1987 to 2011 and contextually carried out a replication study in serum by ourselves as well. We found
- PMID 22738721
Japanese Journal
- クルクミン含有漢方生薬、鉄含有食品摂取により鉄代謝異常が修飾されたCronkhite-Canada 症候群の1例
- 三好 直美,中村 真一,菅野 仁,齋藤 登,齋藤 洋,野村 馨,MIYOSHI Naomi,NAKAMURA Shinichi,KANNO Hitoshi,SAITO Noboru,SAITO Hiroshi,NOMURA Kaoru
- 東京女子医科大学雑誌 83(6), 408-412, 2013-12-25
- 症例は66歳男性、倦怠感、色素沈着、爪甲分離などを主訴に当院総合診療科を受診。消化管内視鏡検査により上部、下部消化管にポリポーシスを認め、Cronkhite-Canada症候群(CCS)と診断した。受診時、Hb 15.6 g/dl、血清鉄248 μg/dl、総鉄結合能274 μg/dlであり、トランスフェリン鉄飽和率は90.5 %と高値を呈した。一方貯蔵鉄量を示す血清フェリチンは34 ng/mlと …
- NAID 110009659605
- クエン酸第二鉄を長期間経口投与した成熟ラットのトランスフェリン飽和率と肝臓への鉄蓄積
- 吉田 宗弘,山川 裕久,西村 直恭 [他]
- Biomedical research on trace elements 24(4), 190-198, 2013
- NAID 40019954113
Related Links
- Transferrin Saturation In the original NHANES I, serum transferrin saturation was measured. The percentage of serum transferrin saturation was calculated by National Center for Health Statistics personnel by dividing the serum iron ...
- Transferrin saturation, measured as a percentage, is a medical laboratory value. It is the ratio of serum iron and total iron-binding capacity, multiplied by 100. For an explanation of some clinical situations in which this ratio is ...
★リンクテーブル★
[★]
- 英
- transferrin saturation, TSAT
- 同
- トランスフェリン飽和率, Tf飽和率
- 関
- トランスフェリン
[show details]
定義
- トランスフェリン飽和度 = Fe / TIBC x 100 [%]
判定
臨床意義
- TSATが15%未満で鉄補給は必須。(臨床透析 vol.24 no.1 2008 p.38)
- 慢性腎臓病の患者では血清フェリチン濃度 100ng/ml以下が絶対的鉄欠乏と考えられている。
参考
- http://docs.jsdt.or.jp/pdf/guideline3/2004_9.pdf
[★]
トランスフェリン飽和度 transferrin saturation
[★]
トランスフェリン