WordNet

of or relating to trabeculae (同)trabeculate
rod-shaped structures of fibrous tissue that divide an organ into parts (as in the penis) or stabilize the structure of an organ (as in the spleen)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/04 13:48:19」(JST)

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The trabecular meshwork is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea).

The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal flowing into the blood system.

Parts

The meshwork is divided up into three parts, with characteristically different ultrastructures:

Inner uveal meshwork - Closest to the anterior chamber angle, contains thin cord-like trabeculae, orientated predominantly in a radial fashion, enclosing trabeculae spaces larger than the corneoscleral meshwork.
Corneoscleral meshwork - Contains a large amount of elastin, arranged as a series of thin, flat, perforated sheets arranged in a laminar pattern; considered the ciliary muscle tendon.^[1]
Juxtacanalicular tissue (also known as the cribriform meshwork) - Lies immediately adjacent to Schlemm's canal, composed of connective tissue ground substance full of glycoaminoglycans and glycoproteins. This thin strip of tissue is covered by a monolayer of endothelial cells.

The trabecular meshwork is assisted to a small degree in the drainage of aqueous humour by a second outflow pathway, the uveo-scleral pathway (5-10% of outflow occurs this way). The uveo-scleral pathway is increased with the use of glaucoma drugs such as prostaglandins (e.g., Xalatan, Travatan).

Role in Glaucoma

Glaucoma is thought to be caused by an increase in intraocular pressure. Pressure increases either when too much aqueous humor fluid is produced or by decreased aqueous humor outflow. The trabecular meshwork is responsible for most of the outflow of aqueous humor.

References

^ Sampaolesi R, Sampaolesi JR, Zárate G (2009). "Ocular Embryology with Special Reference to Chamber Angle Development" (chapter 8). The Glaucomas - Pediatric Glaucomas (volume 1). Springer Berlin Heidelberg. pp. 61-69. ISBN 978-3-540-69146-4. http://www.springerlink.com/content/rkp83w0822835376/

External links

BU Histology Learning System: 08005loa
trabecular+reticulum at eMedicine Dictionary
Diagram at glaucoma-association.com

UpToDate Contents

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1. 幼児および小児における緑内障の概要 overview of glaucoma in infants and children
2. 原発性乳児緑内障 primary infantile glaucoma
3. 外傷性前房出血：臨床的特徴および診断 traumatic hyphema clinical features and diagnosis
4. 開放隅角緑内障：疫学、臨床症状、および診断 open angle glaucoma epidemiology clinical presentation and diagnosis
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English Journal

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P.SourceDepartment of Experimental and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy. dpieragostino@unich.it.
Molecular bioSystems.Mol Biosyst.2013 Jun 7;9(6):1108-16. doi: 10.1039/c3mb25463a. Epub 2013 Apr 12.
Primary open angle glaucoma (POAG) is one of the main causes of irreversible blindness worldwide. The pathogenesis of POAG is still unclear. Alteration and sclerosis of trabecular meshwork with changes in aqueous humor molecular composition seem to play the key role. Increased intraocular pressure i
PMID 23580065

The role of transforming growth factor β in glaucoma and the therapeutic implications.

Prendes MA, Harris A, Wirostko BM, Gerber AL, Siesky B.SourceDepartment of Ophthalmology, Indiana University School of Medicine, , Indianapolis, Indiana, USA.
The British journal of ophthalmology.Br J Ophthalmol.2013 Jun;97(6):680-6. doi: 10.1136/bjophthalmol-2011-301132. Epub 2013 Jan 15.
Glaucoma is a progressive optic neuropathy frequently associated with elevated intraocular pressure, ocular vascular changes and extracellular matrix remodelling at the optic nerve head and in the trabecular meshwork. The pathogenesis is multifactorial and complex, but many recent studies have sugge
PMID 23322881

Japanese Journal

緑内障治療薬の探索と薬理学的検討

岐阜薬科大学紀要 = The annual proceedings of Gifu Pharmaceutical University 64, 21-27, 2015-06-30
NAID 120005681990

第117回日本眼科学会総会特別講演前房隅角と緑内障の病態,診断,治療

日本眼科学会雑誌 118(3), 189-214, 2014-03
NAID 40020014126

Trabectome™を用いた線維柱帯切開術と白内障同時手術による術後屈折誤差の検討

日本視能訓練士協会誌 43(0), 87-91, 2014
NAID 130004822873

Related Pictures

★リンクテーブル★

リンク元	「線維柱帯」「小柱網」「線維柱帯網」「trabecular reticulum」「reticulum trabeculare」
関連記事	「trabecular」「meshwork」

「線維柱帯」

Trabecular meshwork
	Enlarged general view of the iridial angle. (When enlarged, visible with older label of 'trabecular tissue')
Latin	reticulum trabeculare sclerae
Gray's	subject #225 1006
MeSH	Trabecular+Meshwork

　　[★]

英: trabecular meshwork、trabecula、trabeculae、trabecular
関: 柵状織、小柱状、小柱網、トラベキュラ、柱、索、骨梁、線維柱帯網

「小柱網」

　　[★]

英: trabecular meshwork、trabecular reticulum、reticulum trabeculare
関: 線維柱帯、線維柱帯網

「線維柱帯網」

　　[★]

英: trabecular meshwork、trabecular reticulum、reticulum trabeculare
関: 小柱網、線維柱帯

「trabecular reticulum」

　　[★]

線維柱帯網、小柱網

関: reticulum trabeculare、trabecular meshwork

「reticulum trabeculare」

　　[★]

小柱網、線維柱帯網

関: trabecular meshwork、trabecular reticulum

「trabecular」

　　[★]

小柱状の、柵状織の、線維柱帯の

関: trabecula、trabeculae、trabecular meshwork

「meshwork」

　　[★]

n.

網目構造、網目状構造

関: anastomosis

[1] Sampaolesi R, Sampaolesi JR, Zárate G (2009). "Ocular Embryology with Special Reference to Chamber Angle Development" (chapter 8). The Glaucomas - Pediatric Glaucomas (volume 1). Springer Berlin Heidelberg. pp. 61-69. ISBN 978-3-540-69146-4. http://www.springerlink.com/content/rkp83w0822835376/

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案内

trabecular meshwork