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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/07 15:37:37」(JST)

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Tosufloxacin is a fluoroquinolone antibiotic. It has a controversial safety profile in relation to other fluoroquinolones. It is associated with severe thrombocytopenia and nephritis, and hepatotoxicity.^[1] It is sold in Japan under the brand name Ozex.

References

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy. 47 Suppl 3: 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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1. 好酸球性胃腸炎 eosinophilic gastroenteritis

English Journal

Tosufloxacin Deposits in Compromised Corneas.

Kim YD1, Kim MK, Wee WR, Choi HJ.
Optometry and vision science : official publication of the American Academy of Optometry.Optom Vis Sci.2014 Jul 17. [Epub ahead of print]
PURPOSE: To report the adverse effects of topical tosufloxacin in two patients with corneal deposits in compromised cornea.CASE REPORT: Tosufloxacin was administered topically to a 13-month-old girl after penetrating keratoplasty in the left eye. Three days posttransplantation, corneal precipitation
PMID 25036547

[Mn2+-cTMAB-sensitized fluorescent microscopic determination of tosufloxacin tosylate based on a self-ordered ring].

Deng FY, Huang CX, Liu Y.
Guang pu xue yu guang pu fen xi = Guang pu.Guang Pu Xue Yu Guang Pu Fen Xi.2014 Feb;34(2):445-9.
With the development of antimicrobial drugs, drug residue in animal products has a serious potential hazards for the environment and public health, it is urgent to set up drug residue detection method with low detection limit and good selectivity. In our paper, with poly (vinyl alcohol)-124 (PVA-124
PMID 24822418

Effects of fluoroquinolone eye solutions without preservatives on human corneal epithelial cells in vitro.

Oum BS1, Kim NM, Lee JS, Park YM.
Ophthalmic research.Ophthalmic Res.2014;51(4):216-23. doi: 10.1159/000357976. Epub 2014 Apr 10.
AIMS: To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro.METHODS: We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxac
PMID 24732570

Japanese Journal

Comparative study of tosufloxacin tosilate fine granules 15% for pediatrics : MEIJI versus Ozex

ANDO SOICHIRO
The Japanese journal of antibiotics 70(2), 85-96, 2017-04
NAID 40021173331

小児細菌性外眼部感染症に対するトスフロキサシントシル酸塩水和物点眼液0.3%の臨床的評価および原因菌の薬剤感受性

大野重昭,田中知暁,久志本理
あたらしい眼科 31(12), 1857-1866, 2014-12
NAID 40020315275

臨床研究・症例報告マイコプラズマ肺炎へのトスフロキサシントシル酸塩水和物の治療効果について

田中政幸,赤堀史絵
小児科臨床 67(5), 821-824, 2014-05
NAID 40020042108

「トスフロキサシン」

Tosufloxacin
Systematic (IUPAC) name
	7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	100490-36-6
ATC code	None
PubChem	CID 5517
UNII	GHJ553KQPS
KEGG	D02317
ChEBI	CHEBI:77573
ChEMBL	CHEMBL273348
Chemical data
Formula	C19H15F3N4O3
Mol. mass	404.34 g/mol
	SMILES NC1CCN(C1)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F;
	InChI InChI=1S/C19H15F3N4O3/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29) ; Key:WUWFMDMBOJLQIV-UHFFFAOYSA-N ;
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英: tosufloxacin
化: トシル酸トスフロキサシン tosufloxacin tosilate、トスフロキサシントシル酸塩
商: オゼックス、トスキサシン、トスフロ

[1] Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy. 47 Suppl 3: 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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案内

案内

tosufloxacin tosilate