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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/24 12:00:49」(JST)

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Tosufloxacin is a fluoroquinolone antibiotic. It has a controversial safety profile in relation to other fluoroquinolones. It is associated with severe thrombocytopenia and nephritis, and hepatotoxicity.^[1] It is sold in Japan under the brand name Ozex.

References

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy 47 Suppl 3: 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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English Journal

Moxifloxacin is more effective than tosufloxacin in reducing chemotherapy-induced febrile neutropneia in patients with hematological malignancies.

Shinohara A, Yoshiki Y, Masamoto Y, Hangaishi A, Nannya Y, Kurokawa M.SourceDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
Leukemia & lymphoma.Leuk Lymphoma.2013 Jan 2. [Epub ahead of print]
Recent studies have shown the prophylactic efficacy of fluoroquinolones against infections in patients with chemotherapy-induced neutropenia. However, little is known about the differences between fluoroquinolones, and there are some concerns about the emergence of resistant bacteria. In this retros
PMID 22978686

Rapid Effectiveness of Minocycline or Doxycycline Against Macrolide-Resistant Mycoplasma pneumoniae Infection in a 2011 Outbreak Among Japanese Children.

Okada T, Morozumi M, Tajima T, Hasegawa M, Sakata H, Ohnari S, Chiba N, Iwata S, Ubukata K.SourceDepartment of Pediatrics, National Hospital Organization Tokyo Medical Center.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2012 Dec;55(12):1642-9. doi: 10.1093/cid/cis784. Epub 2012 Sep 12.
Background. Mycoplasma pneumoniae is a major pathogen causing community-acquired pneumonia in children and young adults. Outbreaks typically occur at intervals of several years. In 2011, a widespread outbreak was associated with macrolide-resistant M. pneumoniae (MRMP) in Japanese children, often
PMID 22972867

Japanese Journal

ヒト培養細胞内侵入Haemophilus influenzaeに対するトスフロキサシンの影響 : インフルエンザ菌による小児急性中耳炎反復メカニズムの視覚化と治療の可能性

The Japanese journal of antibiotics 69(5), 309-318, 2016-10
NAID 40020987106

2013年に気道感染症小児から分離されたA群溶血性レンサ球菌の細菌学的検討―過去4回の調査成績と比較して―

医学検査 65(2), 229-234, 2016
NAID 130005151816

小児マイコプラズマ感染症の治療期間に影響を与える要因の探索

医療薬学 41(1), 24-29, 2015
NAID 130005119750

Related Pictures

Sparrho | Crystalline nephropathy caused by tosufloxacin. (PDF) Therapeutic efficacy of azithromycin, clarithromycin, minocycline and [Full text] Corneal deposits associated with topical tosufloxacin following penetr | IMCRJ Synthetic Antibacteria Agents List of Items｜Family Pharmacy Global PHARMACOSTECH (PDF) A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active Fluroquinolone ppt

★リンクテーブル★

リンク元	「トスフロキサシン」
拡張検索	「tosufloxacin tosilate」

「トスフロキサシン」

Tosufloxacin
Systematic (IUPAC) name
	7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	100490-36-6
ATC code	None
PubChem	CID 5517
UNII	GHJ553KQPS
KEGG	D02317
ChEMBL	CHEMBL273348
Chemical data
Formula	C19H15F3N4O3
Mol. mass	404.34 g/mol
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