torasemide

トラセミド

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torsemide

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/14 05:23:27」(JST)

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Torasemide

Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy category	US: C (Risk not ruled out)
Legal status	US: ℞-only
Routes of administration	Oral, IV
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Biological half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Number	56211-40-6 Y
ATC code	C03CA04
PubChem	CID: 41781
IUPHAR/BPS	7312
DrugBank	DB00214 Y
ChemSpider	38123 Y
UNII	W31X2H97FB Y
KEGG	D00382 Y
ChEBI	CHEBI:9637 N
ChEMBL	CHEMBL1148 Y
Chemical data
Formula	C16H20N4O3S
Molecular mass	348.421 g/mol
SMILES O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)NC(=O)NC(C)C
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.

References

External links

• Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient

English Journal

• Loop Diuretics in the Treatment of Hypertension.

• Malha L1, Mann SJ2.
• Current hypertension reports.Curr Hypertens Rep.2016 Apr;18(4):27. doi: 10.1007/s11906-016-0636-7.
• Loop diuretics are not recommended in current hypertension guidelines largely due to the lack of outcome data. Nevertheless, they have been shown to lower blood pressure and to offer potential advantages over thiazide-type diuretics. Torsemide offers advantages of longer duration of action and once
• PMID 26951244

• Effect of photodynamic therapy combined with torasemide on the expression of matrix metalloproteinase 2 and sodium-potassium-chloride cotransporter 1 in rat peritumoral edema and glioma.

• Li BO1, Meng C2, Zhang X3, Cong D1, Gao X1, Gao W1, Ju D1, Hu S1.
• Oncology letters.Oncol Lett.2016 Mar;11(3):2084-2090. Epub 2016 Feb 9.
• Peritumoral edema is a key stage in the infiltration and recurrence of glioma. Photodynamic therapy (PDT) increases the extent of peritumoral edema, which leads to a decrease in the effectiveness of PDT in treating glioma. The present study evaluated the effects of PDT combined with torasemide on th
• PMID 26998126

• Veterinary torasemide.

• [No authors listed]
• The Veterinary record.Vet Rec.2016 Feb 27;178(9):221. doi: 10.1136/vr.i1160.
• PMID 26917846

Japanese Journal

• トラセミド投与後に生じた疱疹状天疱瘡の1例 (特集 水疱症)

• 吉村 紫,西島 千博,稲沖 真 [他]
• 皮膚科の臨床 53(7), 972-974, 2011-07
• NAID 40018909225

• 臨床研究・症例報告 先天性心疾患術前・術後におけるトラセミドの使用経験

• 田村 真通,豊野 学朋,岡崎 三枝子 [他]
• 小児科臨床 63(8), 1761-1767, 2010-08
• NAID 40017199515

Related Links

• Torasemide - Wikipedia, the free encyclopedia

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension.

• Torasemide | Medicine | Patient.co.uk

Torasemide is used to treat oedema (fluid retention) caused by heart failure. If the heart becomes less efficient at pumping blood around the body, fluid...

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「トラセミド」

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torasemide

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トルセミド

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メモ

• トラセミド8mgに対してフロセミド20mgに相当するとのことだが根拠は不明である。
• 抗アルドステロン作用があり、低カリウム血症が起こりにくいとのことだが、その程度は不明である。