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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/12 16:35:41」(JST)

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Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.^[1]

References

^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. doi:10.2165/00003495-199549010-00009. PMID 7705212.

External links

Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient

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UpToDate Contents

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1. ループ利尿剤：最大有効量および主な副作用 loop diuretics maximum effective dose and major side effects
2. 心不全患者における利尿剤の使用 use of diuretics in patients with heart failure
3. 成人における難治性浮腫の治療 treatment of refractory edema in adults
4. Pharmacologic therapy of heart failure with reduced ejection fraction
5. 高血圧治療におけるサイアザイド系利尿剤とループ利尿剤の比較 thiazides versus loop diuretics in treatment of hypertension

English Journal

[New drugs for small animals in 2015].

Emmerich IU1.
Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.Tierarztl Prax Ausg K Kleintiere Heimtiere.2016 Jun 16;44(3):171-8. doi: 10.15654/TPK-160399. Epub 2016 May 24.
In 2015, four active pharmaceutical ingredients were released on the German market for small animals. These were the calcium-channel blocker Amlodipine (Amodip®), the benzodiazepine Diazepam (Ziapam®), the allylamine antifungal agent Terbinafine (Osurnia®) and the loop diuretic Torasemide (UpCard
PMID 27223466

Loop Diuretics in the Treatment of Hypertension.

Malha L1, Mann SJ2.
Current hypertension reports.Curr Hypertens Rep.2016 Apr;18(4):27. doi: 10.1007/s11906-016-0636-7.
Loop diuretics are not recommended in current hypertension guidelines largely due to the lack of outcome data. Nevertheless, they have been shown to lower blood pressure and to offer potential advantages over thiazide-type diuretics. Torsemide offers advantages of longer duration of action and once
PMID 26951244

Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial).

Mentz RJ1, Hasselblad V2, DeVore AD3, Metra M4, Voors AA5, Armstrong PW6, Ezekowitz JA7, Tang WH8, Schulte PJ2, Anstrom KJ2, Hernandez AF3, Velazquez EJ3, O'Connor CM3.
The American journal of cardiology.Am J Cardiol.2016 Feb 1;117(3):404-11. doi: 10.1016/j.amjcard.2015.10.059. Epub 2015 Nov 18.
Furosemide is the most commonly used loop diuretic in patients with heart failure (HF) despite data suggesting potential pharmacologic and antifibrotic benefits with torsemide. We investigated patients with HF in Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure who
PMID 26704029

Japanese Journal

Torsemide inhibits aldosterone secretion in vitro

GOODFRIEND TL
Life Sci. 63, PL45-PL50, 1998
NAID 80010396415

Pharmacokinetics and pharmacodynamics of torsemide and furosemide in patients with diuretic resistant ascites

GENTILINI P.
J Hepatology 25, 481-490, 1996
NAID 30007962647

Related Pictures

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★リンクテーブル★

リンク元	「トルセミド」「torasemide」

「トルセミド」

Torasemide
Systematic (IUPAC) name
	N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy; category	US: C (Risk not ruled out);
Legal status	US: ℞-only;
Routes of; administration	Oral, IV
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Biological half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Registry Number	56211-40-6
ATC code	C03CA04
PubChem	CID: 41781
IUPHAR/BPS	7312
DrugBank	DB00214
ChemSpider	38123
UNII	W31X2H97FB
KEGG	D00382
ChEBI	CHEBI:9637
ChEMBL	CHEMBL1148
Chemical data
Formula	C16H20N4O3S
Molecular mass	348.421 g/mol
	SMILES O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)NC(=O)NC(C)C ;
	InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) ; Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N ;
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