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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
3. 亜急性および慢性腰痛：薬物治療と非侵襲的治療 subacute and chronic low back pain pharmacologic and noninterventional treatment
4. クリンダマイシン：概要 clindamycin an overview
5. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults

Muscle relaxants--the current position in the treatment of spasticity in orthopedics.

Zygmunt M1, Sapa J1.
Ortopedia, traumatologia, rehabilitacja.Ortop Traumatol Rehabil.2015 Jul-Aug;17(4):423-30. doi: 10.5604/15093492.1173500.
Muscle tone often exists concomitantly with pain symptoms in different neurological and orthopaedic disease entities. In order to overcome that painful symptom, it is crucial to integrate painkillers with adjunctive therapy using muscle relaxants which decrease the muscle tone. Muscle relaxants avai
PMID 26468180

Acute toxicity profile of tolperisone in overdose: Observational poison centre-based study.

Martos V1, Hofer KE, Rauber-Lüthy C, Schenk-Jaeger KM, Kupferschmidt H, Ceschi A.
Clinical toxicology (Philadelphia, Pa.).Clin Toxicol (Phila).2015 Jun;53(5):470-6. doi: 10.3109/15563650.2015.1022896. Epub 2015 Mar 14.
INTRODUCTION: Tolperisone is a centrally acting muscle relaxant that acts by blocking voltage-gated sodium and calcium channels. There is a lack of information on the clinical features of tolperisone poisoning in the literature. The aim of this study was to investigate the demographics, circumstance
PMID 25772423

Influence of CYP2D6 and CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy volunteers.

Pawlowska M1, Bogiel M, Duda J, Sieradzki E.
European journal of clinical pharmacology.Eur J Clin Pharmacol.2015 Jun;71(6):699-705. doi: 10.1007/s00228-015-1856-5. Epub 2015 May 9.
PURPOSE: This is the first study that connects pharmacokinetics of tolperisone with genetic polymorphism of the enzymes involved in its metabolism in human. We aimed to identify the influence of polymorphism of two main enzymes (CYP2D6 and CYP2C19) on pharmacokinetic profile of parent drug.METHODS:
PMID 25953735

Method for Recording Spinal Reflexes in Mice: Effects of Thyrotropin-Releasing Hormone, DOI, Tolperisone and Baclofen on Monosynaptic Spinal Reflex Potentials

OKADA Hiroki,HONDA Motoko,ONO Hideki
The Japanese journal of pharmacology 86(1), 134-136, 2001-05-01
… Thyrotropin-releasing hormone (TRH) and 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI) produced transient and long-lasting increases in the MSR amplitude, respectively. … Tolperisone hydrochloride and baclofen produced transient and long-lasting MSR depressions, respectively. …
NAID 10007121872

平川雅章,吉川学,大坪健司,片岡泰文,大石了三
病院薬学 22(5), 521-526, 1996-10-10
… A ground mixture of tolperisone hydrochloride (TH)(Muscalm S^<[O!R]>) and dantrolene sodium (DS)(Dantrium^<[O!R]>) was prepared for a 4-year-old patient with cerebral paralysis. …
NAID 110001799610