WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

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1. 特発性脳出血：病因、臨床的特徴、および診断 spontaneous intracerebral hemorrhage pathogenesis clinical features and diagnosis
2. 感覚消失患者へのアプローチ approach to the patient with sensory loss
3. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease
4. パーキンソン病の診断 diagnosis of parkinson disease
5. 神経有棘赤血球症 neuroacanthocytosis

Effects of local activation and blockade of dopamine D4 receptors in the spiking activity of the reticular thalamic nucleus in normal and in ipsilateral dopamine-depleted rats.

Barrientos R, Alatorre A, Martínez-Escudero J, García-Ramírez M, Oviedo-Chávez A, Delgado A, Querejeta E.
Brain research. 2019 Jun;1712()34-46.
The reticular thalamic nucleus (RTn) controls the overall activity of thalamo-cortical neurons information processing. GABAergic RTn neurons have one of the highest densities of D4-type dopamine receptors in subcortical structures. The unitary electrical activity of RTn neurons was recorded in vivo
PMID 30716288

Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism.

Reis C, Sharott A, Magill PJ, van Wijk BCM, Parr T, Zeidman P, Friston KJ, Cagnan H.
NeuroImage. 2019 Jun;193()103-114.
Parkinson's disease (PD) is a neurodegenerative condition in which aberrant oscillatory synchronization of neuronal activity at beta frequencies (15-35 Hz) across the cortico-basal ganglia-thalamocortical circuit is associated with debilitating motor symptoms, such as bradykinesia and rigidity. Mo
PMID 30862535

Fatal familial insomnia and Agrypnia Excitata: Autonomic dysfunctions and pathophysiological implications.

Baldelli L, Provini F.
Autonomic neuroscience : basic & clinical. 2019 May;218()68-86.
Fatal Familial Insomnia (FFI) is a hereditary prion disease caused by a mutation at codon 178 of the prion-protein gene leading to a D178N substitution in the protein determining severe and selective atrophy of mediodorsal and anteroventral thalamic nuclei. FFI is characterized by physiological slee
PMID 30890351

山田和慶,篠島直樹,浜崎禎
脳神経外科ジャーナル 26(12), 873-881, 2017
<p> パーキンソン病 (PD) ・不随意運動症の治療アルゴリズムにおいて重要な一角を占めるDBSについて, 現状を整理し, 近未来を展望する. </p><p> 【PD】視床下核 (STN)-と淡蒼球内節 (GPi)-DBSの総合的な優劣はつけ難い. むしろ使い分けの議論が必要であろう. 一般にレボドパ反応性の欠如は, DBS除外基準であるが, 薬剤抵抗性体軸症 …
NAID 130006279255

谷口豪,鮫島達夫
総合病院精神医学 28(2), 113-120, 2016
<p>電気けいれん療法（ECT）は1938年に統合失調症の治療法として開発されたが，背景にはけいれんと精神病症状は生物学的に拮抗するという仮説があった。その後，ECTは統合失調症以外にもうつ病にも有効であることがわかり，近年ではパーキンソン病や視床痛などにも適応を拡大している一方で，てんかん患者の精神症状に対するECTに関しては報告が少なく不明な点が多い。そのため今回は海外文献を基に考 …
NAID 130007615956