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a small plug of medication designed for insertion into the rectum or vagina where it melts

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/05 22:54:38」(JST)

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A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.

Rectal suppositories

Glycerin suppositories (laxative)

In 1991, Abd-El-Maeboud and his colleagues published a study on suppository insertion in The Lancet,^[1] explaining that the "torpedo" shape, when introduced to the patient blunt end first, helps the device to travel internally, increasing its efficacy. The findings of this single study have been challenged as insufficient evidence on which to base clinical practice.^[2]

Four 500 mg paracetamol suppositories

Urethral suppositories

Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction. They are marketed under the name Muse in the United States.^[3] Its use has diminished since the development of oral impotence medications.

Notes

^ Abd-El-Maeboud, K. H.; T. El-Naggar; E. M. M. El-Hawi; S. A. R. Mahmoud; S. Abd-El-Hay (28 September 1991). "Rectal suppository: commonsense and mode of insertion". The Lancet (Elsevier Science) 338 (8770): 798–800. doi:10.1016/0140-6736(91)90676-G. PMID 1681170.
^ Bradshaw, Ann; Lynda Price (20 December 2006). "Rectal suppository insertion: the reliability of the evidence as a basis for nursing practice". Journal of Clinical Nursing (Blackwell Publishing) 16 (1): 98–103. doi:10.1111/j.1365-2702.2005.01519.x.
^ "Muse Suppository - Facts and Comparisons". Drugs.com. Retrieved 4 January 2013.

References

Doyle, D., "Per Rectum: A History of Enemata", Journal of the Royal College of Physicians of Edinburgh, Vol.35, No.4, (December 2005), pp. 367–370.
Payer, L., "How Medical Practice Reflects National Culture", The Sciences, Vol.30, No.4, (July–August 1990), pp. 38–42.

UpToDate Contents

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English Journal

Baofukang suppository promotes the repair of vaginal epithelial cells in response to Candida albicans.

Li T1, Niu X1, Zhang X2, Wang S2, Liu Z3.
AMB Express.AMB Express.2016 Dec;6(1):109. Epub 2016 Nov 9.
Vulvovaginal candidiasis (VVC) is an opportunistic fungal infection predominantly caused by Candida albicans affecting a significant number of women of reproductive age. The Chinese medicine, the Baofukang suppository is widely used in the clinic for its antimicrobial activity and is therefore of gr
PMID 27830496

Which factors should be considered in choosing pessary type and size for pelvic organ prolapse patients in a fitting trial?

Ding J1, Song XC1, Deng M1, Zhu L2,3.
International urogynecology journal.Int Urogynecol J.2016 Dec;27(12):1867-1871. Epub 2016 Jun 3.
INTRODUCTION AND HYPOTHESIS: This study explored whether the optimal pessary type and size can be predicted using the specific pelvic organ prolapse quantification system (POP-Q) measurements in women with pelvic organ prolapse in a fitting trial.METHODS: We conducted a prospective study in women wh
PMID 27260324

Female pelvic organ prolapse using pessaries: systematic review.

de Albuquerque Coelho SC1, de Castro EB1, Juliato CR2.
International urogynecology journal.Int Urogynecol J.2016 Dec;27(12):1797-1803. Epub 2016 Mar 18.
INTRODUCTION AND HYPOTHESIS: The purpose of this systematic review is to assess the impact of pessary use on the quality of life of women with pelvic organ prolapse, and to determine the satisfaction rate and rationale for discontinuation.METHODS: This review is recorded in the PROSPERO database und
PMID 26992725

Japanese Journal

Pharmaceutical Studies of Levothyroxine Sodium Hydrate Suppository Provided as a Hospital Preparation

Hamada Yuhei,Masuda Kazushi,Okubo Masato [他]
Biological & pharmaceutical bulletin 38(4), 625-628, 2015-04
NAID 40020412180

Studies on Uniformity of the Active Ingredients in Acetaminophen Suppositories Re-solidified after Melting under High Temperature Conditions

Yamamoto Yoshihisa,Fukami Toshiro,Koide Tatsuo [他]
Chemical and pharmaceutical bulletin 63(4), 263-272, 2015-04
NAID 40020412117

Pharmaceutical Studies of Levothyroxine Sodium Hydrate Suppository Provided as a Hospital Preparation

, , , , ,
Biological and Pharmaceutical Bulletin 38(4), 625-628, 2015
… The levothyroxine sodium hydrate suppository (L-T4-suppository) is provided as a hospital preparation for the treatment of hypothyroid patients with dysphagia in Japan because only oral preparations of levothyroxine sodium (L-T4) are approved for the treatment of hypothyroidism. … However, it has been found that serum thyroxine and triiodothyronine levels do not increase as expected with the hospital preparation, requiring a higher dosage of L-T4 in the L-T4-suppository than in the oral preparations. …
NAID 130005062267