WordNet
- the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
- rousing or quickening activity or the senses; "a stimulating discussion"
PrepTutorEJDIC
- ホルモン
- 刺激する;激励する,元気づける
UpToDate Contents
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English Journal
- Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.
- Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, Neri L, Cavallini GM, Altavilla D, Botticelli AR, Squadrito F, Guarini S.Author information Department of Biomedical, Metabolic and Neural Sciences, Section of Pharmacology and Molecular Medicine, University of Modena and Reggio Emilia, Modena, Italy.AbstractBesides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in occasional studies performed in AD-type dementia patients. Here we investigated the possible neuroprotective role of melanocortins in a chronic neurodegenerative disorder, AD, by using 12-week-old (at the start of the study) triple-transgenic (3xTg-AD) mice harboring human transgenes APPSwe, PS1M146V, and tauP301L. Treatment of 3xTg-AD mice, once daily until the end of the study (30 weeks of age), with the melanocortin analog [Nle(4),D-Phe(7)]-α-melanocyte-stimulating hormone (NDP-α-MSH) reduced cerebral cortex/hippocampus phosphorylation/level of all AD-related biomarkers investigated (mediators of amyloid/tau cascade, oxidative/nitrosative stress, inflammation, apoptosis), decreased neuronal loss, induced over-expression of the synaptic activity-dependent gene Zif268, and improved cognitive functions, relative to saline-treated 3xTg-AD mice. Pharmacological blockade of melanocortin MC4 receptors prevented all neuroprotective effects of NDP-α-MSH. Our study identifies, for the first time, a class of drugs, MC4 receptor-stimulating melanocortins, that are able to counteract the progression of experimental AD by targeting pathophysiological mechanisms up- and down-stream of β-amyloid and tau. These data could have important clinical implications.
- Neurobiology of aging.Neurobiol Aging.2014 Mar;35(3):537-47. doi: 10.1016/j.neurobiolaging.2013.08.030. Epub 2013 Oct 1.
- Besides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in
- PMID 24094579
- Penta- and octa-bromodiphenyl ethers promote proinflammatory protein expression in human bronchial epithelial cells in vitro.
- Koike E1, Yanagisawa R2, Takigami H3, Takano H4.Author information 1Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan. Electronic address: ekoike@nies.go.jp.2Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.3Center for Material Cycles and Waste Management Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.4Graduate School of Engineering, Kyoto University, Kyoto daigaku-Katsura, Nishikyo-ku, Kyoto 615-8530, Japan.AbstractPolybrominated diphenyl ethers (PBDEs) are widely used as flame retardants in consumer products. Humans can be exposed to PBDEs mainly through the inhalation of air or dust. Thus, PBDEs can affect respiratory and immune systems. In the present study, we investigated whether PBDEs stimulate bronchial epithelial cells. We examined commercial penta-BDE (DE-71), octa-BDE (DE-79), and deca-BDE (DE-83R). Human bronchial epithelial cells (BEAS-2B) were exposed to each PBDE for 24h. Subsequently, the expression of intercellular adhesion molecule-1 (ICAM-1) and proinflammatory cytokines were investigated. DE-71 and DE-79, but not DE-83R, significantly increased the expression of ICAM-1, interleukin-6 (IL-6), and IL-8 in BEAS-2B. Because these remarkable effects were observed with DE-71, we further investigated the underlying intracellular mechanisms. DE-71 promoted epidermal growth factor receptor (EGFR) phosphorylation. Inhibitors of EGFR-selective tyrosine kinase and p38 mitogen-activated protein kinase effectively blocked the increase of IL-6 and IL-8. Furthermore, antagonists of thyroid hormone receptor and aryl hydrocarbon receptor significantly suppressed the increase in IL-6 and/or IL-8 production. In conclusion, penta- and octa-BDE, but not deca-BDE, might promote the expression of proinflammatory proteins in bronchial epithelial cells possibly by activating protein kinases and/or stimulating nuclear receptors related to subsequent activation of transcriptional factors.
- Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Mar;28(2):327-33. doi: 10.1016/j.tiv.2013.10.014. Epub 2013 Oct 30.
- Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants in consumer products. Humans can be exposed to PBDEs mainly through the inhalation of air or dust. Thus, PBDEs can affect respiratory and immune systems. In the present study, we investigated whether PBDEs stimulate bronchial
- PMID 24184330
- The environmental regulation of maturation in goldfish, Carassius auratus: Effects of various LED light spectra.
- Shin HS1, Habibi HR2, Choi CY3.Author information 1Division of Marine Environment & BioScience, Korea Maritime and Ocean University, Busan 606-791, Republic of Korea.2Department of Biological Sciences, University of Calgary, 2500 University Drive N.W. Calgary, Alberta T3B 2V4, Canada. Electronic address: habibi@ucalgary.ca.3Division of Marine Environment & BioScience, Korea Maritime and Ocean University, Busan 606-791, Republic of Korea. Electronic address: choic@kmou.ac.kr.AbstractWhile there have been a number of studies on the effects of photoperiod and duration of light and dark exposure, much less information is available on the importance of light intensity. This study investigated the effects of exposure of goldfish, Carassius auratus exposed to white fluorescent bulbs, and red (peak at 630nm), and green (530nm) light emitting diodes (LEDs) at approximately 0.9W/m(2) (12-h light:12-h dark) for four months on a number of hormones of the hypothalamus-pituitary-gonad (HPG) axis, in vivo and in vitro. We investigated the effects of native GnRH molecules (gonadotropin-releasing hormones; salmon GnRH, sGnRH; and chicken GnRH-II, cGnRH-II), gonadotropin hormones (GTHα; follicle-stimulating hormone, FSH-β; luteinizing hormone, LH-β2), kisspeptin 1 (Kiss1) and G protein-coupled receptor 54 (GPR54) mRNA levels. Furthermore, we measured LH and 17α-hydroxypregnenolone levels in plasma and we performed gonad histological observations. GnRHs, Kiss1, GPR54 and GTH mRNA and plasma LH and 17α-hydroxypregnenolone levels in the in vivo and in vitro groups exposed to green LEDs were significantly higher than the other groups. Histological analysis revealed the presence of oocytes in the yolk stage in fish exposed to green light. These results suggest that green wavelengths regulate the HPG axis and enhance sexual maturation in goldfish.
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2014 Feb;168:17-24. doi: 10.1016/j.cbpa.2013.11.003. Epub 2013 Nov 13.
- While there have been a number of studies on the effects of photoperiod and duration of light and dark exposure, much less information is available on the importance of light intensity. This study investigated the effects of exposure of goldfish, Carassius auratus exposed to white fluorescent bulbs,
- PMID 24239668
Japanese Journal
- Ovulation Induction with Follicle-Stimulating Hormone Administration in Hawksbill Turtles Eretmochelys imbricata
- KAWAZU ISAO,SUZUKI MIWA,MAEDA KONOMI [他],Kino Masakatsu,Koyago Masanori,Moriyoshi Masaharu,Nakada Ken,Sawamukai Yutaka
- Current Herpetology 33(1), 88-93, 2014
- … To develop ovulation induction techniques, we investigated the effects of follicle-stimulating hormone (FSH) administration on ovulation in captive hawksbill turtles Eretmochelys imbricata. …
- NAID 130003393158
- Association between a Serum Thyroid-stimulating Hormone Concentration within the Normal Range and Indices of Obesity in Japanese Men and Women
- Sakurai Masaru,Nakamura Koshi,Miura Katsuyuki,Yoshita Katsushi,Takamura Toshinari,Nagasawa Shin-ya,Morikawa Yuko,Ishizaki Masao,Kido Teruhiko,Naruse Yuchi,Nakashima Motoko,Nogawa Kazuhiro,Suwazono Yasushi,Nakagawa Hideaki
- Internal Medicine 53(7), 669-674, 2014
- … Objective This cross-sectional study investigated the associations between the serum thyroid-stimulating hormone (TSH) concentration and indices of obesity in middle-aged Japanese men and women. …
- NAID 130003392739
- Graves' Ophthalmopathy: Epidemiology and Natural History
- Hiromatsu Yuji,Eguchi Hiroyuki,Tani Junichi,Kasaoka Masataka,Teshima Yasuo
- Internal Medicine 53(5), 353-360, 2014
- … Aging, thyroid dysfunction, thyroid stimulating hormone (TSH) receptor antibodies, smoking and radioiodine treatment for hyperthyroidism also influence the development and course of GO. …
- NAID 130003392691
Related Links
- デジタル大辞泉 - TSHの用語解説 - 《thyroid-stimulating hormone》⇒甲状腺刺激ホルモン ... 【脳下垂体】より …ストレスから体を守る働きをするホルモンで，動物がストレスに出会った場合，このホルモンの分泌が増加して副腎皮質ホルモン ...
- デジタル大辞泉 - FSHの用語解説 - 《follicle-stimulating hormone》卵胞刺激ホルモン。脳下垂体前葉から分泌されるホルモンで、卵巣の卵胞を成熟させ、卵胞ホルモンの分泌を促進させる。
★リンクテーブル★
[★]
- 英
- stimulating hormone, stimulatory hormone, tropic hormone
- 関
- ホルモン
[★]
α-メラノサイト刺激ホルモン
[★]
[★]
甲状腺刺激ホルモン
[★]
甲状腺刺激ホルモン
[★]
- 関
- exciting、irritant