English Journal

GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.

Tessitore A1, del P Martin M, Sano R, Ma Y, Mann L, Ingrassia A, Laywell ED, Steindler DA, Hendershot LM, d'Azzo A.
Molecular cell.Mol Cell.2004 Sep 10;15(5):753-66.
GM1-ganglioside (GM1) is a major sialoglycolipid of neuronal membranes that, among other functions, modulates calcium homeostasis. Excessive accumulation of GM1 due to deficiency of lysosomal beta-galactosidase (beta-gal) characterizes the neurodegenerative disease GM1-gangliosidosis, but whether th
PMID 15350219

Biological properties of N-acyl and N-haloacetyl neuraminic acids: processing by enzymes of sialic acid metabolism, and interaction with influenza virus.

Humphrey AJ1, Fremann C, Critchley P, Malykh Y, Schauer R, Bugg TD.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2002 Oct;10(10):3175-85.
Several unnatural N-acyl neuraminic acids (N-propionyl, N-hexanoyl, N-benzoyl, N-trifluoroacetyl, N-chloroacetyl, N-difluoroacetyl) were prepared enzymatically using immobilised sialic acid aldolase. N-Trifluoroacetyl-, N-chloroacetyl- and N-difluoroacetyl neuraminic acids were shown to enhance up t
PMID 12150863

Schnitzer JE1, Oh P, McIntosh DP.
Science (New York, N.Y.).Science.1996 Oct 11;274(5285):239-42.
Caveolae are specialized invaginated cell surface microdomains of undefined function. A cell-free system that reconstituted fission of caveolae from lung endothelial plasma membranes was developed. Addition of cytosol and the hydrolysis of guanosine triphosphate (GTP) induced caveolar fission. The b
PMID 8824187

Japanese Journal

Physicochemical Studies on the Phospholipid Bilayer Incorporated Sialoglycolipid

Kaneko Hideo,Murahashi Naokazu,Sasaki Atsushi [他],YAMADA Harutami,SAKAGAMI Masahiro,IKEDA Masahiro
Chemical & pharmaceutical bulletin 45(6), 951-956, 1997-06-15
… It was inferred that the effect was attributable to a difference in the position of the sialoglycolipid incorporated in the bilayer membrane. …
NAID 110003616599