関: shigellosis

WordNet

an acute infection of the intestine by shigella bacteria; characterized by diarrhea and fever and abdominal pains (同)bacillary_dysentery
(medicine) the invasion of the body by pathogenic microorganisms and their multiplication which can lead to tissue damage and disease
(phonetics) the alteration of a speech sound under the influence of a neighboring sound
the pathological state resulting from the invasion of the body by pathogenic microorganisms
(international law) illegality that taints or contaminates a ship or cargo rendering it liable to seizure
moral corruption or contamination; "ambitious men are led astray by an infection that is almost unavoidable"
an incident in which an infectious disease is transmitted (同)contagion, transmission
rod-shaped Gram-negative enterobacteria; some are pathogenic for warm-blooded animals; can be used as a bioweapon

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〈U〉(病気の)伝染;感染 / 〈C〉伝染病

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1. 赤痢菌感染：臨床症状および診断 shigella infection clinical manifestations and diagnosis
2. 赤痢菌感染：小児における治療および予防 shigella infection treatment and prevention in children
3. 赤痢菌感染：成人における治療および予防 shigella infection treatment and prevention in adults
4. 赤痢菌感染：疫学、微生物学、および病因 shigella infection epidemiology microbiology and pathogenesis
5. 資源の限られた国における成人の急性下痢に対するアプローチ approach to the adult with acute diarrhea in resource limited countries

English Journal

Fusion of HPV L1 into Shigella surface IcsA: A new approach in developing live attenuated Shigella-HPV vaccine.

Xu D1, Wang D2, Yang X3, Cao M2, Yu J4, Wang Y5.Author information 1Institute of Cancer Research, School of Life Sciences and Technology, Xi'an Jiaotong University, Xi'an 710061, China; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.2Institute of Cancer Research, School of Life Sciences and Technology, Xi'an Jiaotong University, Xi'an 710061, China.3The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.4Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.5Institute of Cancer Research, School of Life Sciences and Technology, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: wangyili@mail.xjtu.edu.cn.AbstractDespite the success of L1 virus-like particles (VLPs) vaccines in prevention of high-risk human papillomavirus (HPV) infection and cervical cancer, extraordinary high cost for the complete vaccination has impeded widespread use of the vaccine in resource-poor countries, where cervical cancers impose greater challenge. Presentation of HPV L1 protein by attenuated pathogenic bacteria through natural infection provides a promising low-cost and convenient alternative. Here, we describe the construction and characterization of attenuated L1-expressing Shigella vaccine candidate, by fusion of L1 into the autotransporter of Shigella sonnei, IcsA, an essential virulence factor responsible for actin-based motility. The functional α domain of IcsA was replaced by codon-optimized L1 gene with independent open reading frames (ORFs) facilitated by suicide vector pJCB12. The L1 gene was stabilized in the genome of recombinant S. sonnei with protein expression and assembly of VLPs in the bacterial cytoplasm. Through conjunctival route vaccination in guinea pigs, L1-containing S. sonnei was able to elicit specific immune response to HPV16 L1 VLP as well as bacterial antigens. The results demonstrated the feasibility of the novel stratagem to develop prophylactic Shigella-HPV vaccines.
Antiviral research.Antiviral Res.2014 Feb;102:61-9. doi: 10.1016/j.antiviral.2013.12.003. Epub 2013 Dec 13.
Despite the success of L1 virus-like particles (VLPs) vaccines in prevention of high-risk human papillomavirus (HPV) infection and cervical cancer, extraordinary high cost for the complete vaccination has impeded widespread use of the vaccine in resource-poor countries, where cervical cancers impose
PMID 24333518

'Gay bowel syndrome': relic or real (and returning) phenomenon?

Cooper F, Barber T.Author information aChelsea and Westminster NHS Foundation Trust bHomerton University Hospital NHS Foundation Trust, London, UK.AbstractPURPOSE OF REVIEW: This article aims to review the term 'gay bowel syndrome', including the recent research looking at increased rates of bowel infections in men who have sex with men (MSM), particularly in light of the recent Shigella outbreaks in MSM in London and New York, and considers whether 'gay bowel syndrome' is a syndrome that really exists and is worthy of further research and specific treatment, or whether the term continues to be obsolete and not useful.
Current opinion in infectious diseases.Curr Opin Infect Dis.2014 Feb;27(1):84-9. doi: 10.1097/QCO.0000000000000032.
PURPOSE OF REVIEW: This article aims to review the term 'gay bowel syndrome', including the recent research looking at increased rates of bowel infections in men who have sex with men (MSM), particularly in light of the recent Shigella outbreaks in MSM in London and New York, and considers whether '
PMID 24335755

EatA, an Immunogenic Protective Antigen of Enterotoxigenic Escherichia coli, Degrades Intestinal Mucin.

Kumar P, Luo Q, Vickers TJ, Sheikh A, Lewis WG, Fleckenstein JM, Payne SM.Author information Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.AbstractEnterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to infectious diarrhea in developing countries for which there is presently no effective vaccine. A central challenge in ETEC vaccinology has been the identification of conserved surface antigens to formulate a broadly protective vaccine. Here, we demonstrate that EatA, an immunogenic secreted serine protease of ETEC, contributes to virulence by degrading MUC2, the major protein present in the small intestinal mucous layer, and that removal of this barrier in vitro accelerates toxin access to the enterocyte surface. In addition, we demonstrate that vaccination with the recombinant secreted passenger domain of EatA (rEatAp) elicits high titers of antibody and is protective against intestinal infection with ETEC. These findings may have significant implications for development of both subunit and live-attenuated vaccines against ETEC and other enteric pathogens, including Shigella flexneri, that express similar proteins.
Infection and immunity.Infect Immun.2014 Feb;82(2):500-8. doi: 10.1128/IAI.01078-13. Epub 2013 Nov 11.
Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to infectious diarrhea in developing countries for which there is presently no effective vaccine. A central challenge in ETEC vaccinology has been the identification of conserved surface antigens to formulate a b
PMID 24218479

Japanese Journal

病原細菌のAB5型トキシンの作用機構等に関する研究

野田公俊
日本細菌学雑誌 68(3), 299-311, 2013
病原細菌のAB5型トキシンは1個のAサブユニットと5個のBサブユニットから構成される外毒素である。両サブユニットはそれぞれ特徴的な役割を持ち，互いに巧妙に機能分担をして一つのトキシンを形成している。Aサブユニットは主に毒性に直接関与する特異的な酵素活性を有する。一方，Bサブユニットは標的細胞のレセプターに対する結合能を有し，AB5型トキシンを標的細胞に吸着させる。ここでは毒性が全く異なるAB5型ト …
NAID 130003369344

Diffuse outbreak 患者から分離されたCTX-M-15型基質拡張型βラクタマーゼ遺伝子保有 Shigella sonnei

瀬戸順次,稲毛稔
感染症学雑誌 : 日本伝染病学会機関誌 : the journal of the Japanese Association for Infectious Diseases 86(5), 608-609, 2012-09-20
NAID 10031144085

平成24年浅川賞受賞論文赤痢菌の病原性の研究 : 粘膜バリアーにおける病原体と宿主の相互作用の研究

笹川千尋
日本細菌学雑誌 67(4), 257-268, 2012
… Shigella are capable of invading and colonizing the intestinal epithelium, which results in strong inflammatory colitis. … Shigella deliver a subset of effectors via the type III secretion system during infection into host cells. … The delivered effectors mimic and usurp the host cellular functions, and modulate host cell signaling and immune response, thus playing pivotal roles in promoting the bacterial infection and circumventing host defense systems. …
NAID 130002553167