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the branch of medical science that deals with serums; especially with blood serums and disease
of or relating to serology (同)serological

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/08 21:43:01」(JST)

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Serology is the scientific study of blood serum and other bodily fluids. In practice, the term usually refers to the diagnostic identification of antibodies in the serum.^[1] Such antibodies are typically formed in response to an infection (against a given microorganism),^[2] against other foreign proteins (in response, for example, to a mismatched blood transfusion), or to one's own proteins (in instances of autoimmune disease).

Serological tests may be performed for diagnostic purposes when an infection is suspected, in rheumatic illnesses, and in many other situations, such as checking an individual's blood type.^[1] Serology blood tests help to diagnose patients with certain immune deficiencies associated with the lack of antibodies, such as X-linked agammaglobulinemia. In such cases, tests for antibodies will be consistently negative.

There are several serology techniques that can be used depending on the antibodies being studied. These include: ELISA, agglutination, precipitation, complement-fixation, and fluorescent antibodies.

Some serological tests are not limited to blood serum, but can also be performed on other bodily fluids such as semen and saliva, which have (roughly) similar properties to serum.

Serological tests may also be used forensically, specifically a piece of evidence (e.g., linking a rapist to a semen sample).

Serological surveys

Serological surveys are often used by epidemiologists to determine the prevalence of a disease in a population. Such surveys are sometimes performed by random, anonymous sampling from samples taken for other sexual tests.

References

^ ^a ^b Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 247–9. ISBN 0-8385-8529-9.
^ Washington JA (1996). Principles of Diagnosis: Serodiagnosis. in: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.5462.

External links

Serology – MedlinePlus Medical Encyclopedia
Serologic+Tests at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

A case of progressively transformed germinal center-type IgG4-related lymphadenopathy.

Seki N1, Yamazaki N2, Koizumi J3, Takano K4, Abe A4, Ikeda T5, Noguchi H6, Himi T4.
Auris, nasus, larynx.Auris Nasus Larynx.2015 Aug;42(4):345-7. doi: 10.1016/j.anl.2015.02.010. Epub 2015 Feb 21.
Progressively transformed germinal centers (PTGC), a lymph node process unfamiliar to most otolaryngologists, is a morphological variant of reactive lymphofollicular hyperplasia of lymph nodes. Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a newly identified condition, characterized by hyper-Ig
PMID 25717025

Primary laryngeal cryptococcosis resembling laryngeal carcinoma.

Tamagawa S1, Hotomi M2, Yuasa J1, Tuchihashi S1, Yamauchi K1, Togawa A1, Yamanaka N1.
Auris, nasus, larynx.Auris Nasus Larynx.2015 Aug;42(4):337-40. doi: 10.1016/j.anl.2015.01.003. Epub 2015 Feb 18.
A case of an 82-year-old female with primary laryngeal cryptococcosis who had undergone long-term corticosteroid therapy for chronic obstructive pulmonary disease and rheumatoid arthritis is reported. She complained hoarseness with swallowing pain and irritability of the larynx for over a month. End
PMID 25701260

A review of neosporosis and pathologic findings of Neospora caninum infection in wildlife.

Donahoe SL1, Lindsay SA1, Krockenberger M1, Phalen D1, Šlapeta J1.
International journal for parasitology. Parasites and wildlife.Int J Parasitol Parasites Wildl.2015 Apr 24;4(2):216-38. doi: 10.1016/j.ijppaw.2015.04.002. eCollection 2015.
Neospora caninum is an apicomplexan parasite that is the etiologic agent of neosporosis, a devastating infectious disease regarded as a major cause of reproductive loss in cattle and neuromuscular disease in dogs worldwide. This protozoan pathogen is maintained in the environment by a heteroxenous l
PMID 25973393