WordNet

of or relating to serology (同)serological
the branch of medical science that deals with serums; especially with blood serums and disease
an assay that relies on an enzymatic conversion reaction and is used to detect the presence of specific substances (such as enzymes or viruses or antibodies or bacteria) (同)ELISA

PrepTutorEJDIC

血清学

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/25 22:25:49」(JST)

wiki en

[Wiki en表示]

Serology is the scientific study of blood serum and other bodily fluids. In practice, the term usually refers to the diagnostic identification of antibodies in the serum.^[1] Such antibodies are typically formed in response to an infection (against a given microorganism),^[2] against other foreign proteins (in response, for example, to a mismatched blood transfusion), or to one's own proteins (in instances of autoimmune disease).

Serological tests may be performed for diagnostic purposes when an infection is suspected, in rheumatic illnesses, and in many other situations, such as checking an individual's blood type.^[1] Serology blood tests help to diagnose patients with certain immune deficiencies associated with the lack of antibodies, such as X-linked agammaglobulinemia. In such cases, tests for antibodies will be consistently negative.

There are several serology techniques that can be used depending on the antibodies being studied. These include: ELISA, agglutination, precipitation, complement-fixation, and fluorescent antibodies.

Some serological tests are not limited to blood serum, but can also be performed on other bodily fluids such as semen and saliva, which have (roughly) similar properties to serum.

Serological tests may also be used forensically, specifically a piece of evidence (e.g., linking a rapist to a semen sample).

Serological surveys

Serological surveys are often used by epidemiologists to determine the prevalence of a disease in a population. Such surveys are sometimes performed by random, anonymous sampling from samples taken for other sexual tests.

References

^ ^a ^b Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 247–9. ISBN 0-8385-8529-9.
^ Washington JA (1996). Principles of Diagnosis: Serodiagnosis. in: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.5462.

External links

Serology – MedlinePlus Medical Encyclopedia
Serologic+Tests at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. サイトメガロウイルス感染の診断検査の概要 overview of diagnostic tests for cytomegalovirus infection
2. 自己免疫性肝炎の血清学的マーカー serologic markers of autoimmune hepatitis
3. 性器潰瘍患者へのアプローチ approach to the patient with genital ulcers
4. ライム病の診断 diagnosis of lyme disease
5. Hepatitis B virus immunization in infants, children, and adolescents

English Journal

Diagnosis of congenital Trypanosoma cruzi infection: A serologic test using Shed Acute Phase Antigen (SAPA) in mother-child binomial samples.

Volta BJ1, Russomando G2, Bustos PL1, Scollo K1, De Rissio AM1, Sánchez Z3, Cardoni RL1, Bua J4.
Acta tropica.Acta Trop.2015 Jul;147:31-7. doi: 10.1016/j.actatropica.2015.03.026. Epub 2015 Apr 3.
Chagas congenital infection is an important health problem in endemic and non-endemic areas in which Trypanosoma cruzi-infected women can transmit the parasite to their offspring. In this study, we evaluated the antibody levels against the T. cruzi Shed Acute Phase Antigen (SAPA) in 91 binomial samp
PMID 25847262

P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African Americans.

Penman A1, Hoadley S2, Wilson JG3, Taylor HA4, Chen CJ2, Sobrin L5.
American journal of ophthalmology.Am J Ophthalmol.2015 Jun;159(6):1152-1160.e2. doi: 10.1016/j.ajo.2015.03.008. Epub 2015 Mar 17.
PURPOSE: To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population.DESIGN: Prospective
PMID 25794792

Ocular Involvement Following an Epidemic of Toxoplasma gondii Infection in Santa Isabel do Ivaí, Brazil.

Silveira C1, Muccioli C2, Holland GN3, Jones JL4, Yu F5, de Paulo A2, Belfort R Jr2.
American journal of ophthalmology.Am J Ophthalmol.2015 Jun;159(6):1013-1021.e3. doi: 10.1016/j.ajo.2015.02.017. Epub 2015 Mar 2.
PURPOSE: To investigate ocular involvement (prevalence, incidence, lesion characteristics) following postnatally acquired infection with an "atypical" genotype of Toxoplasma gondii during a well-characterized 2001 outbreak in Santa Isabel do Ivaí, Brazil, attributed to a contaminated municipal rese
PMID 25743340

Japanese Journal

Seroepidemiology of Hepatitis A in South Korea: A Nationwide Study by the Eone Reference Laboratory

Cho Sung Eun,Kim Youngdae
Journal of Epidemiology, 2013
… Background: We evaluated the recent prevalence of serologic markers of hepatitis A virus (HAV) in South Korea.<BR>Methods: The study data were the results of 60 126 anti-HAV (total) tests and 30 786 anti-HAV IgM tests that were performed during April 2009 through March 2010 by the Eone Reference Laboratory at the request of 1935 institutions throughout Korea.<BR>Results: The overall positivity rate was 51.06% on the anti-HAV (total) test and 11.20% on the anti-HAV IgM test. …
NAID 130003364508

Serologic Reports of H3N2 Canine Influenza Virus Infection in Dogs in Northeast China

ZHANG Yong-Biao,CHEN Ji-Dang,XIE Jie-Xiong,ZHU Wan-Jun,WEI Chun-Ya,TAN Li-Kai,CAO Nan,CHEN Ye,ZHANG Min-Ze,ZHANG Gui-Hong,LI Shou-Jun
Journal of Veterinary Medical Science, 2013
Reports of dogs with H3N2 canine influenza virus (CIV) have been documented frequently. To better understand the seroprevalence of H3N2 CIV among dogs in northeast China, here we report for the first …
NAID 130003362178

Neutralizing Antibodies Are Associated with a Reduction of Interferon-β Efficacy during the Treatment of Japanese Multiple Sclerosis Patients

SATO Douglas Kazutoshi,NAKASHIMA Ichiro,FUKAZAWA Toshiyuki,SHIMIZU Yuko,TOMIZAWA Yuji,YOKOYAMA Kazumasa,MISU Tatsuro,CREEKE Paul I.,FARRELL Rachel,GIOVANNONI Gavin,ITOYAMA Yasuto,FUJIHARA Kazuo,AOKI Masashi
Tohoku journal of experimental medicine 228(2), 85-92, 2012-10-01
NAID 10031120234