sense strand

センス鎖、有意鎖

関

coding strand

WordNet

1. detect some circumstance or entity automatically; "This robot can sense the presence of people in the room"; "particle detectors sense ionization"
2. the faculty through which the external world is apprehended; "in the dark he had to depend on touch and on his senses of smell and hearing" (同)sensation, sentience, sentiency, sensory faculty
3. the meaning of a word or expression; the way in which a word or expression or situation can be interpreted; "the dictionary gave several senses for the word"; "in the best sense charity is really a duty"; "the signifier is linked to the signified" (同)signified
4. a general conscious awareness; "a sense of security"; "a sense of happiness"; "a sense of danger"; "a sense of self"
5. a natural appreciation or ability; "a keen musical sense"; "a good sense of timing"
6. comprehend; "I sensed the real meaning of his letter"
7. drive (a vessel) ashore
8. line consisting of a complex of fibers or filaments that are twisted together to form a thread or a rope or a cable
9. a pattern forming a unity within a larger structural whole; "he tried to pick up the strands of his former life"; "I could hear several melodic strands simultaneously"
10. a poetic term for a shore (as the area periodically covered and uncovered by the tides)
11. detected by instinct or inference rather than by recognized perceptual cues; "the felt presence of an intruder"; "a sensed presence in the room raised goosebumps on her arms"; "a perceived threat" (同)perceived
12. becoming aware of something via the senses (同)perception
13. a fractional monetary unit of Japan and Indonesia and Cambodia; equal to one hundredth of a yen or rupiah or riel

PrepTutorEJDIC

1. 〈C〉(五感による)『感覚』;(…の)感覚《+『of』+『名』》 / 〈U〉《しばしばa~》(…の)『感じ』,気持ち《+『of』+『名』》 / 〈U〉《a~,one's~》(…の)『理解』(『認識』)『力』,観念,センス《+『of』+『名』》 / 《one's senses》正常な感覚,正気 / 〈C〉《しばしば冠詩をつけないで》分別,良識 / 〈C〉(行動・発言・文などの)意義,意味(meaning)《+of(in)+名(do『ing』)》 / 〈U〉(…の)(全体的な)意向,動向《+『of』+『名』》 / …‘を'感ずる,‘に'気づく
2. 〈船〉‘を'座礁させる / 《受動態で》〈人〉‘を'置き去りにする,困った状態におく / 〈船が〉座礁する / 〈人が〉途方に暮れる,立ち往生する / 岸,浜
3. こ撚(よ)り(何本かより合わせて糸・なわなどにするその一本) / (より合わせた)糸,ひも;(頭髪の)房 / (真珠・ビーズなど)ひもに通したもの

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/13 18:56:28」(JST)

wiki en

[Wiki en表示]

In genetics, a sense strand, or coding strand, is the segment within double-stranded DNA that runs from 5' to 3', and which is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein. The antisense strand is thus responsible for the RNA that is later translated to protein, while the sense strand possesses a nearly identical makeup to that of the mRNA. Note that for each segment of dsDNA, there will possibly be two sets of sense and antisense, depending on which direction one reads (since sense and antisense is relative to perspective). It is ultimately the gene product, or mRNA, that dictates which strand of one segment of dsDNA we call sense or antisense. But keep in mind that sometimes, such as in prokaryotes, overlapping genes on opposite strands means the sense for one mRNA can be the antisense for another mRNA.

The immediate product of this transcription is a resultant initial RNA transcript, which contains a sequence of nucleotides that is identical to the that of the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine.

Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This process typically involves removal of introns from the initial RNA transcript, the addition of a methylated guanine nucleotide cap at the 5' end, and the addition of a poly-A tail at the 3' end. This deletion process is known as splicing. The end product is known as a mature mRNA. Prokaryotic mRNA does not undergo the same process.

Strictly speaking, only the mRNA makes "sense" with the genetic code, as the translated protein peptide sequence can be directly inferred from this strand. The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis.

Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense" strands.

Identifying the different strands is also important in understanding small interfering RNAs, or siRNA.

References

Merrill, Dr. Gary F. 'Transcription', lecture notes distributed in Biochemistry 451 General Biochemistry, Oregon State University, Weigend on 6 Jun. 2006.

External links

• Sense and antisense strands of DNA: YouTube tutorial video

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 分子遺伝学の原理 principles of molecular genetics
• 2. 遺伝性疾患の基本原則 basic principles of genetic disease
• 3. 自己免疫の概要 overview of autoimmunity
• 4. 小児におけるパラインフルエンザウイルス parainfluenza viruses in children
• 5. 成人におけるパラインフルエンザウイルス parainfluenza viruses in adults

English Journal

• The complete mitochondrial genome of the hybrid of Megalobrama skolkovii (♀) × Megalobrama amblycephala (♂).

• Chen B1,2, Wan S1,3, Gao Z1,3.
• Mitochondrial DNA. Part A. DNA mapping, sequencing, and analysis.Mitochondrial DNA A DNA MappSeq Anal.2016 Sep;27(5):3768-9. doi: 10.3109/19401736.2015.1079897. Epub 2015 Sep 2.
• In this study, we sequenced the complete mitochondrial genome of the hybrid of Megalobrama skolkovii (♀) × Megalobrama amblycephala (♂) for the first time. The complete mitochondrial genome of the hybrid bream was found to be 16 621 bp in size with a mostly conserved structural organization
• PMID 26332664

• The complete mitochondrial genome of the hybrid of Megalobrama terminalis (♀) × Megalobrama amblycephala (♂).

• Zhang W1,2, Zhao Y1,2, Guan N1, Nie C1, Zhang X1,2, Gao Z1,2.
• Mitochondrial DNA. Part A. DNA mapping, sequencing, and analysis.Mitochondrial DNA A DNA MappSeq Anal.2016 Jul;27(4):2391-2. doi: 10.3109/19401736.2015.1028045. Epub 2015 Jun 15.
• In this study, the complete mitochondrial genome of the hybrid of Megalobrama terminalis (♀) × Megalobrama amblycephala (♂) was determined. The total length of the genome was 16,622 bp in accordance with the female parent, and the overall base composition was 31.13% A, 24.94% T, 27.72% C
• PMID 26075479

• An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.

• Bienk K1, Hvam ML1, Pakula MM1, Dagnæs-Hansen F2, Wengel J3, Malle BM4, Kragh-Hansen U2, Cameron J5, Bukrinski JT4, Howard KA6.
• Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2016 Jun 28;232:143-51. doi: 10.1016/j.jconrel.2016.04.013. Epub 2016 Apr 12.
• Major challenges for the clinical translation of small interfering RNA (siRNA) include overcoming the poor plasma half-life, site-specific delivery and modulation of gene silencing. In this work, we exploit the intrinsic transport properties of human serum albumin to tune the blood circulatory half-
• PMID 27084489

Japanese Journal

• ヘテロキラルDNAダイマーの右巻きらせん形成能およびRNAダイマーとの比較

• 浦田 秀仁,平田 好宏,田路 貴子 [他],落合 郁美,赤木 昌夫
• Viva origino 39(1-4), 49-54, 2012-06-20
• 自己複製分子のホモキラリティーの確立とRNAワールド仮説との関連を考察する一環として,2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine[d(ApA)]の4種の光学異性体[D-d(ApA),d(ADpAL),d(ALpAD),L-d(ApA)]を合成し,それらの右巻きらせん形成能について検討を行った.円二色性(CD)スペクトルからD-d(ApA)とd(ALpAD) …
• NAID 110009470538

• siRNA-NESコンジュゲートの合成、デリバリー、遺伝子サイレンシング

• 藤井 政幸,Diala Irmina
• かやのもり : 近畿大学産業理工学部研究報告 -(15) (-), 1-6, 2011-00-00
• … As a result, two types of siRNA-NES conjugates C1 and C2 were prepared in which 5' -end of sense strand was covalently linked to N-terminus of the NES peptides derived from TFIIIA and HIV-1rev, respectively. … It can be also pointed out that modification of 5' -endo of sense strand reduced off-target effect by minimizing the extent of the sense strand incorporation into RISC. …
• NAID 120003753053

• ヌクレアーゼ抵抗性化学修飾核酸の開発研究

• 松田 彰
• YAKUGAKU ZASSHI 131(2), 285-298, 2011
• … We found that siRNAs, which have 4 residues of SNs on both ends of the sense strand and 4 residues on the 3′-end of the antisense strand, were the most effective. …
• NAID 130000451463

Related Links

• sense strand - definition of sense strand in the Medical ...

sense strand, the strand of a double-stranded nucleic acid that encodes the product. In DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. Compare antisense strand. ...

• Sense strand dictionary definition | sense strand defined

+ Add to Word List Create new word list More... Word List Title: 3 to 50 characters max. Word List Description: 3 to 250 characters max. Shared Private Definitions sense strand Genetics that strand of a double-stranded DNA ...

Related Pictures

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★リンクテーブル★

リンク元	「センス鎖」「有意鎖」
拡張検索	「antisense strand」
関連記事	「strand」「sense」「sensing」

「センス鎖」

　　[★]

英

sense strand

関

アンチセンス鎖、転写

「有意鎖」

　　[★]

英

sense strand、coding strand

関

センス鎖

「antisense strand」

　　[★]

アンチセンス鎖、反意鎖

「strand」

　　[★]

• vt.,vi.

• 座礁させる、(岸に)打ち上げられる、(浜に)取り残される

a 26-year-old woman is stranded for more than a week when her hiking trip is interrupted by an avalanche.

　 　 　 　 　 　

「sense」

　　[★]

• n.

• センス、意味、感覚

関

implication、imply、mean、meaning、purport、represent、semantic、sensation、sensory

　 　 　 　 　 　 　

「sensing」

　　[★]

• n.

• センシング

• adj.

• 感覚性の

関

sensory