- セグメント・ラリティー遺伝子、セグメント・ラリティ遺伝子
WordNet
- divide or split up; "The cells segmented"
- one of the parts into which something naturally divides; "a segment of an orange"
- divide into segments; "segment an orange"; "segment a compound word" (同)section
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- having an indicated pole (as the distinction between positive and negative electric charges); "he got the polarity of the battery reversed"; "charges of opposite sign" (同)sign
- informal term for information; "give me the gen on your new line of computers"
PrepTutorEJDIC
- 区分,部分 / 切片(円などの一部);(直線の)線分 / …‘を'分ける / 分かれている,分裂する
- 遺伝子
- （磁石・電池の）両極性;陽(陰)極性 / (性格・傾向などについて)両極端,正反対
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/04 23:15:17」(JST)
[Wiki en表示]
A segmentation gene is a generic term for a gene whose function is to specify tissue pattern in each repeated unit of a segmented organism. In the fruit fly Drosophila melanogaster, segment polarity genes help to define the anterior and posterior polarities within each embryonic parasegment by regulating the transmission of signals via the Wnt signaling pathway and Hedgehog signaling pathway. Segment polarity genes are expressed in the embryo following expression of the gap genes and pair-rule genes. The most commonly cited examples of these genes are engrailed and gooseberry in D. melanogaster.[1]
References
- ^ "Segment polarity gene - definition from Biology-Online.org". 2009-01-08. Retrieved 2009-12-14.
UpToDate Contents
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English Journal
- The Midline Protein Regulates Axon Guidance by Blocking the Reiteration of Neuroblast Rows within the Drosophila Ventral Nerve Cord.
- Manavalan MA, Gaziova I, Bhat KM.Author information Department of Neuroscience and Cell Biology, University of Texas Medical Branch School of Medicine, Galveston, Texas, United States of America.AbstractGuiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the specific role of the environment in which axons navigate in regulating axon-guidance has not been examined in detail. In Drosophila, the ventral nerve cord is divided into segments, and half-segments and the precursor neuroblasts are formed in rows and columns in individual half-segments. The row-wise expression of segment-polarity genes within the neuroectoderm provides the initial row-wise identity to neuroblasts. Here, we show that in embryos mutant for the gene midline, which encodes a T-box DNA binding protein, row-2 neuroblasts and their neuroectoderm adopt a row-5 identity. This reiteration of row-5 ultimately creates a non-permissive zone or a barrier, which prevents the extension of interneuronal longitudinal tracts along their normal anterior-posterior path. While we do not know the nature of the barrier, the axon tracts either stall when they reach this region or project across the midline or towards the periphery along this zone. Previously, we had shown that midline ensures ancestry-dependent fate specification in a neuronal lineage. These results provide the molecular basis for the axon guidance defects in midline mutants and the significance of proper specification of the environment to axon-guidance. These results also reveal the importance of segmental polarity in guiding axons from one segment to the next, and a link between establishment of broad segmental identity and axon guidance.
- PLoS genetics.PLoS Genet.2013 Dec;9(12):e1004050. doi: 10.1371/journal.pgen.1004050. Epub 2013 Dec 26.
- Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the specific role of the environment in which axo
- PMID 24385932
- Prickle1 stunts limb growth through alteration of cell polarity and gene expression.
- Yang T, Bassuk AG, Fritzsch B.Author information Department of Biology, University of Iowa, Iowa City, Iowa.AbstractBACKGROUND: Wnt/PCP signaling plays a critical role in multiple developmental processes, including limb development. Wnt5a, a ligand of the PCP pathway, signals through the Ror2/Vangl2 or the Vangl2/Ryk complex to regulate limb development along the proximal-distal axis in mice. Based on the interaction between Van Gogh and Prickle in Drosophila, we hypothesized the vertebrate Prickle1 has a similar function as Vangl2 in limb development.
- Developmental dynamics : an official publication of the American Association of Anatomists.Dev Dyn.2013 Nov;242(11):1293-306. doi: 10.1002/dvdy.24025. Epub 2013 Sep 6.
- BACKGROUND: Wnt/PCP signaling plays a critical role in multiple developmental processes, including limb development. Wnt5a, a ligand of the PCP pathway, signals through the Ror2/Vangl2 or the Vangl2/Ryk complex to regulate limb development along the proximal-distal axis in mice. Based on the interac
- PMID 23913870
- Differential and redundant functions of gooseberry and gooseberry neuro in the central nervous system and segmentation of the Drosophila embryo.
- He H, Noll M.Author information Institute of Molecular Life Sciences, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.AbstractThe gooseberry locus of Drosophila consists of two homologous Pax genes, gooseberry neuro (gsbn) and gooseberry (gsb). Originally characterized by genetics as a single segment-polarity gene, its role in segmentation has been enigmatic, as only deficiencies uncovering both genes showed a strong segmentation phenotype while mutants of gsb did not. To solve this conundrum and assay for differential roles of gsbn and gsb, we have obtained by homologous recombination for the first time null mutants of either gene as well as a deficiency inactivating only gsbn and gsb. Our analysis shows that (i) gsbn null mutants are subviable while all surviving males and most females are sterile; (ii) gsb and gsbn share overlapping functions in segmentation and the CNS, in which gsbn largely, but not completely depends on the transcriptional activation by the product of gsb; (iii) as a consequence, in the absence of gsbn, gsb becomes haploinsufficient for its function in the CNS, and gsbn(-/-)gsb(-/+) mutants die as larvae. Such mutants display defects in the proper specification of the SNa branch of the segmental nerve, which appears intact in gsbn(-/-) mutants. Lineage analysis in the embryonic CNS showed that gsbn is expressed in the entire lineage derived from NB5-4, which generates 4 or 5 motoneurons whose axons are part of the SNa branch and all of which except one also express BarH1. Analysis of gsbn(-/-)gsb(-/+) clones originating from NB5-4 further suggests that gsb and gsbn specify the SNa fate and concomitantly repress the SNc fate in this lineage and that their products activate BarH1 transcription. Specification of the SNa fate by Gsb and Gsbn occurs mainly at the NB and GMC stage. However, the SNa mutant phenotype can be rescued by providing Gsbn as late as at the postmitotic stage. The hierarchical relationship between gsb and gsbn, the haploinsufficiency of gsb in gsbn mutants, and their redundant roles in the epidermis and CNS are discussed. A model is proposed how selection for both genes occurred after their duplication during evolution.
- Developmental biology.Dev Biol.2013 Oct 1;382(1):209-23. doi: 10.1016/j.ydbio.2013.05.017. Epub 2013 Jul 22.
- The gooseberry locus of Drosophila consists of two homologous Pax genes, gooseberry neuro (gsbn) and gooseberry (gsb). Originally characterized by genetics as a single segment-polarity gene, its role in segmentation has been enigmatic, as only deficiencies uncovering both genes showed a strong segme
- PMID 23886579
Japanese Journal
- Two Cases of Nevoid Basal Cell Carcinoma Syndrome
- 八木澤 瑞穂,加賀田 博子,佐久間 康徳,佃 守
- 耳鼻咽喉科臨床 97(10), 923-927, 2004
- … NBCCS is caused by mutations in the patched gene (PTCH), and shows a homologous type of the Drosophilia segment polarity gene (Ptch). … PTCH is a tumor suppressor gene located at 9q22.3.In this paper, two cases of NBCCS in one family, in a girl and her mother are presented. …
- NAID 130001815197
- HUMAN DISEASES INVOLVED IN THE HEDGEHOG SIGNALING SYSTEM
- 楯 玄秀
- 昭和医学会雑誌 62(6), 379-387, 2002
- … The hedgehog (HH) gene, one of the segment polarity genes of Drosophila, was initially reported in 1980. … The HH gene encodes a secretory protein and the Patched (PTCH) gene encodes an HH receptor. …
- NAID 130001822449
- Segmentation in Annelids : Cellular and Molecular Basis for Metameric Body Plan
- Shimizu Takashi,Nakamoto Ayaki
- Zoological science 18(3), 285-298, 2001-04-10
- … e., a linear series) of primary blast cells, which individually serve as a founder cell of each segment ; … Cell-autonomous properties of primary blast cells have also been suggested in two fundamental aspects of segmentation, viz., specification of segment polarity and determination of segmental identities. …
- NAID 110003371929
Related Links
- segment polarity gene definition from the mondofacto online medical dictionary ... Search dictionary help segment polarity gene medical dictionary <molecular biology> A segmentation gene, responsible for specifying anterior posterior polarity ...
- Definition and other additional information on Segment polarity gene from Biology-Online.org dictionary. Login Welcome to biology-online.org! Please login to access all site features. Create account. Log me on automatically each ...
★リンクテーブル★
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- 英
- segment polarity gene
- 関
- セグメント・ラリティー遺伝子
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- 英
- segment polarity gene
- 関
- セグメント・ラリティ遺伝子
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- 関
- area、metameric、region、segmental、somite、somitic
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セグメント・ラリティー