A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration.
Banerjee S, Gordon L, Donn TM, Berti C, Moens CB, Burden SJ, Granato M.SourceDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6058, USA.
Development (Cambridge, England).Development.2011 Aug;138(15):3287-96.
Trunk neural crest cells delaminate from the dorsal neural tube as an uninterrupted sheet; however, they convert into segmentally organized streams before migrating through the somitic territory. These neural crest cell streams join the segmental trajectories of pathfinding spinal motor axons, sugge
Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.
Ribas R, Moncaut N, Siligan C, Taylor K, Cross JW, Rigby PW, Carvajal JJ.AbstractThe transcriptional regulation of the Mrf4/Myf5 locus depends on a multitude of enhancers that, in equilibria with transcription balancing sequences and the promoters, regulate the expression of the two genes throughout embryonic development and in the adult. Transcription in a particular set of muscle progenitors can be driven by the combined outputs of several enhancers that are not able to recapitulate the entire expression pattern in isolation, or by the action of a single enhancer the activity of which in isolation is equivalent to that within the context of the locus. We identified a new enhancer element of this second class, ECR111, which is highly conserved in all vertebrate species and is necessary and sufficient to drive Myf5 expression in ventro-caudal and ventro-rostral somitic compartments in the mouse embryo. EMSA analyses and data obtained from binding-site mutations in transgenic embryos show that a binding site for a TEA Domain (TEAD) transcription factor is essential for the function of this new enhancer, while ChIP assays show that at least two members of the family of transcription factors bind to it in vivo.
The transcriptional regulation of the Mrf4/Myf5 locus depends on a multitude of enhancers that, in equilibria with transcription balancing sequences and the promoters, regulate the expression of the two genes throughout embryonic development and in the adult. Transcription in a particular set of mus
somitic definition: noun 1. metamere 2. a blocklike segment of mesodermal tissue in the vertebrate embryo, giving rise to muscle, bone, etc.Origin of somite; from soma + -iteRelated Forms: 3. somitic adjective or somital ...
Definition of somitic in the Medical Dictionary. somitic explanation. Information about somitic in Free online English dictionary. What is somitic? Meaning of somitic medical term. What does somitic mean? somitic - definition of ...