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Hepcidin production in response to iron is controlled by monocyte-derived humoral factors.

Sasaki Y1, Shimonaka Y, Ikuta K, Hosoki T, Sasaki K, Torimoto Y, Kanada H, Moriguchi Y, Kohgo Y.
International journal of hematology.Int J Hematol.2014 Jan;99(1):12-20. doi: 10.1007/s12185-013-1476-8. Epub 2013 Dec 1.
Hepcidin, which is mainly produced by the liver, is the key regulator in iron homeostasis. Hepcidin expression is up-regulated by iron loading in vivo, but the mechanism underlying this process is not completely understood. In the present study, we investigated the mechanism, following the hypothesi
PMID 24293278

Involvement of iron-evoked oxidative stress in smoking-related endothelial dysfunction in healthy young men.

Fukami K1, Yamagishi S2, Iida S1, Matsuoka H3, Okuda S1.
PloS one.PLoS One.2014 Feb 21;9(2):e89433. doi: 10.1371/journal.pone.0089433. eCollection 2014.
BACKGROUND: Oxidative stress and smoking contribute to endothelial dysfunction. Iron might also play a role in oxidative stress generation and endothelial dysfunction. However, the involvement of iron in smoking-induced endothelial dysfunction in healthy smokers remains unclear. Therefore, we examin
PMID 24586777

Darbepoetin-alfa and intravenous iron administration after autologous hematopoietic stem cell transplantation: a prospective multicenter randomized trial.

Beguin Y1, Maertens J, De Prijck B, Schots R, Seidel L, Bonnet C, Hafraoui K, Willems E, Vanstraelen G, Servais S, Jaspers A, Fillet G, Baron F.
American journal of hematology.Am J Hematol.2013 Dec;88(12):990-6. doi: 10.1002/ajh.23552. Epub 2013 Sep 30.
We conducted a randomized study analyzing the impact of darbepoetin alfa (DA) administration with or without intravenous (i.v.) iron on erythroid recovery after autologous hematopoietic cell transplantation (HCT). Patients were randomized between no DA (Arm 1), DA 300 μg every 2 weeks starting on D
PMID 23873823

山本直,岡田洋右,森博子,黒住旭,鳥本桂一,新生忠司,田中良哉
産業医科大学雑誌 35(1), 25-31, 2013-03-01
症例1は80歳男性.鉄欠乏性貧血に対し約5年間にわたり含糖酸化鉄を経静脈投与され,両膝痛が出現した.低リン血症(1.4 mg/dl),fibroblast growth factor 23(FGF23)248.8mg/dlと高値より,FGF23関連骨軟化症と診断した.含糖酸化鉄の投与中止のみで,1ヶ月後には症状は改善し,血中リンやFGF23も正常化した.症例2は63歳女性.36歳時,胃癌に対し胃切 …
NAID 110009593198

Fibroblast Growth Factor 23-Related Osteomalacia Caused by the Prolonged Administration of Saccharated Ferric Oxide

Yamamoto Sunao,Okada Yosuke,Mori Hiroko,Fukumoto Seiji,Tanaka Yoshiya
Internal Medicine 51(17), 2375-2378, 2012
… A 44-year-old woman with iron deficiency anemia was on a continuous course of intravenous saccharated ferric oxide (SFO). …
NAID 130002062335