WordNet

any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
an official responsible for control and supervision of a particular activity or area of public interest
any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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1. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
2. 拡張能障害の細胞学的機序 cellular mechanisms of diastolic dysfunction
3. グリコーゲン分枝酵素欠損症（糖原病IV型、アンダーセン病） glycogen branching enzyme deficiency glycogen storage disease iv andersen disease
4. 急性心筋梗塞におけるアンギオテンシン変換酵素阻害剤：作用機序 angiotensin converting enzyme inhibitors in acute myocardial infarction mechanisms of action
5. 心臓におけるアンギオテンシンⅡの作用 actions of angiotensin ii on the heart

Morphological and metabolic adjustments in the small intestine to energy demands of growth, storage, and fasting in the first annual cycle of a hibernating lizard (Tupinambis merianae).

do Nascimento LF1, da Silveira LC1, Nisembaum LG1, Colquhoun A2, Abe AS3, Mandarim-de-Lacerda CA4, de Souza SC5.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2016 May;195:55-64. doi: 10.1016/j.cbpa.2016.02.002. Epub 2016 Feb 9.
Seasonal plasticity in the small intestine of neonatal tegu lizards was investigated using morphometry and analysis of enzymes involved in supplying energy to the intestinal tissue. In the autumn, the intestinal mass (Mi) was 1.0% of body mass and the scaling exponent b=0.92 indicated that Mi was la
PMID 26872995

Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.

Rahman MH1, Jha MK1, Kim JH1, Nam Y1, Lee MG1, Go Y2, Harris RA3, Park DH4, Kook H5, Lee IK2, Suk K6.
The Journal of biological chemistry.J Biol Chem.2016 Mar 11;291(11):6011-25. doi: 10.1074/jbc.M115.699215. Epub 2016 Jan 14.
The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen tension that leads to aberrant metabolic functions. Metabolic dysfunctions have been documented to play a crucial role in the
PMID 26769971

Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth.

Hussain A1, Qazi AK1, Mupparapu N2, Guru SK1, Kumar A1, Sharma PR1, Singh SK1, Singh P1, Dar MJ1, Bharate SB2, Zargar MA3, Ahmed QN2, Bhushan S1, Vishwakarma RA2, Hamid A4.
Cancer letters.Cancer Lett.2016 Feb 23. pii: S0304-3835(16)30098-2. doi: 10.1016/j.canlet.2016.02.030. [Epub ahead of print]
Phosphatidylinositol 3-kinase (PI3K) pathway drives cancer progression through direct regulation of most oncogenic properties. Here, we report that PI3K pathway signaling up-regulates cancer cell proliferation, metastasis and angiogenesis through modulation of cancer metabolism. These oncogenic meta
PMID 26921131

篠原康雄
藥學雜誌 120(8), 657-666, 2000-08-01
… Tumor cells show a higher glycolytic rate than normal cells. … Of glycolytic enzymes, the activity of hexokinase, known as a rate limiting enzyme in glycolysis, is amazingly high in malignant tumor cells. … We further investigated the regulatory machanisms of the expression of type II hexokinase in tumor cells. …
NAID 110003648849

Phosphofructokinase, a glycolytic regulatory enzyme has a crucial role for maintenance of synaptic activity in guinea pig hippocampal slices

山田一哉,野口民夫
日本栄養・食糧学会誌 : Nippon eiyo shokuryo gakkaishi = Journal of Japanese Society of Nutrition and Food Science 52(3), 167-173, 1999-06-10
… The L-type isozyme (LPK) gene of pyruvate kinase, an important glycolytic enzyme, is a good example. … Two cis-acting regulatory elements named L-II and L-III are required for transcriptional stimulation of the LPK gene by carbohydrates. …
NAID 10009713382