regulatory gene

• 調節遺伝子、制御遺伝子

関

regulator gene

WordNet

1. any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
2. an official responsible for control and supervision of a particular activity or area of public interest
3. (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
4. informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

1. 取り締まり人;調整者 / 調整装置
2. 遺伝子

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/11 21:21:23」(JST)

wiki en

[Wiki en表示]

A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding microRNAs.

In prokaryotes, regulator genes often code for repressor proteins. Repressor proteins bind to operators or promoters, preventing RNA polymerase from transcribing RNA. They are usually constantly expressed so the cell always has a supply of repressor molecules on hand. Inducers cause repressor proteins to change shape or otherwise become unable to bind DNA, allowing RNA polymerase to continue transcription. Regulator genes can be located within an operon, adjacent to it, or far away from it.

Other regulatory genes code for activator proteins. An activator binds to a site on the DNA molecule and causes an increase in transcription of a nearby gene. In prokaryotes, a well-known example of an activator protein is the catabolite activator protein or CAP, which is involved in positive control of the lac operon.

In the regulation of gene expression, both activators and repressors are known to play important roles.

References

External links

• Regulator Gene at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
• 2. 急性リンパ芽球性白血病における細胞遺伝学 cytogenetics in acute lymphoblastic leukemia
• 3. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
• 4. 全身性硬化症（強皮症）の危険因子および考えられる原因 risk factors for and possible causes of systemic sclerosis scleroderma
• 5. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer

English Journal

• Antitumor effects obtained by autologous Lewis lung cancer cell vaccine engineered to secrete mouse Interleukin 27 by means of cationic liposome.

• Zhang J, Tian H, Li C, Cheng L, Zhang S, Zhang X, Wang R, Xu F, Dai L, Shi G, Chen X, Li Y, Du T, Deng J, Liu Y, Yang Y, Wei Y, Deng H.SourceState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
• Molecular immunology.Mol Immunol.2013 Oct;55(3-4):264-74. doi: 10.1016/j.molimm.2013.02.006. Epub 2013 Mar 21.
• Interleukin-27 (IL-27), a novel IL-6/IL-12 family cytokine, plays an important role in the early regulation of Th1 responses. The cytokine IL-27 can exert a variety of immune-regulatory functions including cytotoxic T lymphocyte (CTL), CD4(+), CD8+ T lymphocytes activation and interferon-γ (IFN-γ)
• PMID 23522926

• microRNAs in cardiac development and regeneration.

• Porrello ER.SourceSchool of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
• Clinical science (London, England : 1979).Clin Sci (Lond).2013 Aug 1;125(4):151-66. doi: 10.1042/CS20130011.
• Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent studies have establi
• PMID 23634935

• TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells.

• Tsapournioti S, Mylonis I, Hatziefthimiou A, Ioannou MG, Stamatiou R, Koukoulis GK, Simos G, Molyvdas PA, Paraskeva E.SourceDepartment of Physiology, School of Medicine, University of Thessaly, Larissa, Greece.
• Journal of cellular physiology.J Cell Physiol.2013 Aug;228(8):1745-53. doi: 10.1002/jcp.24331.
• Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the hypoxia inducible factor, HIF-1α, has been recently shown to be induced by cyt
• PMID 23359428

Japanese Journal

• 複数時系列遺伝子発現プロファイルを利用した遺伝子制御ネットワーク推定の精度向上手法

• 渡邉之人 ,瀬尾茂人 ,竹中要一 ,松田秀雄
• 情報処理学会研究報告. MPS, 数理モデル化と問題解決研究報告 2013-MPS-92(12), 1-6, 2013-02-20
• 複雑な遺伝子間制御関係を解明するために,個々の遺伝子制御関係を統合した遺伝子制御ネットワークの推定が行われている.しかし遺伝子 × 実験条件の行列データである遺伝子発現プロファイルは遺伝子数に比べ 1 実験あたりの測定回数が少ない.そのため遺伝子発現プロファイルの情報量不足を原因とした遺伝子制御ネットワーク推定の精度低下が問題点となる.本研究では情報量不足を軽減するために複数の時系列遺伝子発現プロ …
• NAID 110009550160

• A physical, genetic and functional sequence assembly of the barley genome

• The International Barley Genome Sequencing Consortium
• Nature 491(7426), 711-716, 2012-11-29
• … Here we present an integrated and ordered physical, genetic and functional sequence resource that describes the barley gene-space in a structured whole-genome context. … Abundant alternative splicing, premature termination codons and novel transcriptionally active regions suggest that post-transcriptional processing forms an important regulatory layer. …
• NAID 120005121934

• ノンパラメトリックベイジアンT過程アルゴリズムによる時間的構造変化を考慮した遺伝子発現ネットワーク推定

• 宮下 弘樹,中村 拓磨,井田 安俊,鈴木 知彦,松本 隆,鏑木 崇史
• 情報処理学会研究報告. BIO, バイオ情報学 2012-BIO-32(15), 1-6, 2012-11-29
• 本稿では,ノンパラメトリック・ベイズ的枠組みの一つであるT過程を回帰モデルに用いることにより,時間的に構造が変化するダイナミックベイジアンネットワークを推定することを目的とする.特に,実データとして Drosophila melanogaster の遺伝子発現データを用い,生命現象に内在すると考えられる非線形性の依存関係および各成長段階をおける依存関係の変化を考慮した上での遺伝子発現ネットワーク推 …
• NAID 110009488560

Related Links

• Regulator gene - Wikipedia, the free encyclopedia

A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding ...

• What Is a Regulatory Gene?

A regulatory gene is a gene that determines whether or not other genes will be expressed in an organism. In some cases, regulatory...

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★リンクテーブル★

リンク元	「制御遺伝子」「regulator gene」
関連記事	「regulatory」「regulator」

「制御遺伝子」

　　[★]

英

regulatory gene

関

調節遺伝子

「regulator gene」

　　[★]

• 調節遺伝子

関

regulatory gene

「regulatory」

　　[★]

• adj.

• 制御の、調節性の、制御的な、(法律)規制の

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control、modulatory、regulate、regulation

「regulator」

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• n.

• 制御因子、レギュレーター

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regulatory factor