WordNet

temporarily unresponsive or not fully responsive to nervous or sexual stimuli; "the refractory period of a muscle fiber"
not responding to treatment; "a stubborn infection"; "a refractory case of acne"; "stubborn rust stains" (同)stubborn
a message whose ingenuity or verbal skill or incongruity has the power to evoke laughter (同)humor, humour, witticism, wittiness
abnormal development (of organs or cells) or an abnormal structure resulting from such growth
a deficiency of some cellular element of the blood

PrepTutorEJDIC

(人などが)手に負えない,強情な / (病気が)治りにくい,がんこな / (金属などが)溶けにくい,耐火性の
《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
知る(know)
〈U〉『機知』,機転,ウィット / 〈C〉『機知に富む人』,機転のきく人 / 《複数形で;単数扱い》『理解(表現)力』,知性 / 《複数形で》(物事を見抜いたりもくろんだりする)才覚,才知 / 《複数形で;単数扱い》正気

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/15 21:26:18」(JST)

Refractory cytopenia with multilineage dysplasia is a form of myelodysplastic syndrome.^[1]

It is abbreviated "RCMD".^[2]^[3]

^ Rosati S, Mick R, Xu F, et al. (January 1996). "Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome". Leukemia 10 (1): 20–6. PMID 8558932.
^ Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D (January 2009). "Allogeneic stem cell transplantation for adults with myelodysplastic syndromes: importance of pretransplant disease burden". Biol. Blood Marrow Transplant. 15 (1): 30–8. doi:10.1016/j.bbmt.2008.10.012. PMID 19135940.
^ Hamdi W, Ogawara H, Handa H, Tsukamoto N, Nojima Y, Murakami H (November 2008). "Clinical significance of regulatory T cells in patients with myelodysplastic syndrome". Eur. J. Haematol. 82 (3): 201–7. doi:10.1111/j.1600-0609.2008.01182.x. PMID 19018862.

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1. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
2. 成人における骨髄異形成症候群の予後 prognosis of the myelodysplastic syndromes in adults
3. 鉄芽球性貧血の臨床的側面、診断、および治療 clinical aspects diagnosis and treatment of the sideroblastic anemias
4. 造血腫瘍の分類 classification of the hematopoietic neoplasms
5. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.

Malcovati L1, Karimi M2, Papaemmanuil E3, Ambaglio I4, Jädersten M2, Jansson M2, Elena C1, Gallì A5, Walldin G2, Della Porta MG4, Raaschou-Jensen K6, Travaglino E5, Kallenbach K7, Pietra D5, Ljungström V8, Conte S2, Boveri E9, Invernizzi R10, Rosenquist R8, Campbell PJ3, Cazzola M1, Hellström Lindberg E2.
Blood.Blood.2015 Jul 9;126(2):233-41. doi: 10.1182/blood-2015-03-633537. Epub 2015 May 8.
Refractory anemia with ring sideroblasts (RARS) is a myelodysplastic syndrome (MDS) characterized by isolated erythroid dysplasia and 15% or more bone marrow ring sideroblasts. Ring sideroblasts are found also in other MDS subtypes, such as refractory cytopenia with multilineage dysplasia and ring s
PMID 25957392

Is chronic neutropenia always a benign disease? Evidences from a 5-year prospective study.

Fattizzo B1, Zaninoni A1, Consonni D2, Zanella A1, Gianelli U3, Cortelezzi A4, Barcellini W5.
European journal of internal medicine.Eur J Intern Med.2015 Jun 8. pii: S0953-6205(15)00184-3. doi: 10.1016/j.ejim.2015.05.019. [Epub ahead of print]
AIM: To evaluate infections and oncohematologic evolution in adult patients with chronic idiopathic and autoimmune neutropenia in a prospective study.PATIENTS AND METHODS: 76 consecutive patients were enrolled from September 2008 to April 2012. Complete blood counts and clinical evaluation were perf
PMID 26066399