- 関
- rate-limiting enzyme
WordNet
- be worthy of or have a certain rating; "This bond rates highly"
- amount of a charge or payment relative to some basis; "a 10-minute phone call at that rate would cost $5" (同)charge per unit
- a magnitude or frequency relative to a time unit; "they traveled at a rate of 55 miles per hour"; "the rate of change was faster than expected"
- a quantity or amount or measure considered as a proportion of another quantity or amount or measure; "the literacy rate"; "the retention rate"; "the dropout rate"
- assign a rank or rating to; "how would you rank these students?"; "The restaurant is rated highly in the food guide" (同)rank, range, order, grade, place
- estimate the value of; "How would you rate his chances to become President?"; "Gold was rated highly among the Romans" (同)value
- give (hair) the appearance of being fuller by using a rat
- a pad (usually made of hair) worn as part of a womans coiffure
- any of various long-tailed rodents similar to but larger than a mouse
- catch rats, especially with dogs
- desert ones party or group of friends, for example, for ones personal advantage
- employ scabs or strike breakers in
- standing or position on a scale
- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
- a local tax on property (usually used in the plural)
PrepTutorEJDIC
- 〈C〉『割合』,『率』 / 〈C〉《the~,a~》『速度』(speed),進度 / 〈C〉『値段』,『相場』;料金 / 〈U〉等級(class),(…)等 / 《複数形ぃ》《英》地方税 / (…の金額に)…‘の'『値段を決める』,見積もる《+『名』+『at』+『名』》 / …‘を'『評価する』,みなす / 《米話》…‘に'値する,‘の'価値がある / 『評価される』;みなされる
- …‘を'どなりつける
- 『ネズミ』 / ひきょう者,裏切り者 / ネズミをつかまえる / 《話》(人を)裏切る,密告する《+『on』+『名』〈人〉》
- 〈C〉〈U〉(品質・技量などによる)格づけ,評価 / 〈C〉(個人・会社の経済的な)信用度 / 〈C〉(トン・馬力による)(船舶・車)の等級 / 〈C〉(テレビ・ラジオの)視聴率
- 酵素
UpToDate Contents
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English Journal
- Transport vs. metabolism: what determines the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs? Insights from the extended clearance model.
- Patilea-Vrana G1, Unadkat JD1.
- Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2016 Jul 22. doi: 10.1002/cpt.437. [Epub ahead of print]
- The well-stirred hepatic clearance model (WSHM) has been expanded to include drug transporters (i.e. extended clearance model [ECM]). But, the consequences of this expansion in understanding when transporters vs. metabolic enzymes will affect the PK and PD of drugs remains opaque. Identifying the ra
- PMID 27448198
- Histone Deacetylase 8: Characterization of Physiological Divalent Metal Catalysis.
- Nechay MR1, Gallup NM1, Morgenstern A2, Smith QA1, Eberhart ME2, Alexandrova AN1,3.
- The journal of physical chemistry. B.J Phys Chem B.2016 Jul 7;120(26):5884-95. doi: 10.1021/acs.jpcb.6b00997. Epub 2016 Mar 30.
- Histone deacetylases (HDACs) are responsible for the removal of acetyl groups from histones, resulting in gene silencing. Overexpression of HDACs is associated with cancer, and their inhibitors are of particular interest as chemotherapeutics. However, HDACs remain a target of mechanistic debate. HDA
- PMID 26996235
- Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients.
- Momin AA1, Bankar MP2, Bhoite GM3.
- Indian journal of clinical biochemistry : IJCB.Indian J Clin Biochem.2016 Jul;31(3):286-93. doi: 10.1007/s12291-015-0531-z. Epub 2015 Oct 13.
- Elevated plasma triglyceride and non-esterified fatty acid concentrations may cause insulin resistance and type 2 diabetes mellitus. Lipoprotein lipase (LPL) is a rate-determining enzyme in lipid metabolism. A variant in the LPL gene has been identified which alters the penultimate amino acid Serine
- PMID 27382199
Japanese Journal
- Improvement of Poly(3-Hydroxybutyrate)[P(3HB)] Production in Corynebacterium glutamicum by Codon Optimization, Point Mutation and Gene Dosage of P(3HB) Biosynthetic Genes(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Jo Sung-Jin,Matsumoto Ken'ichiro,Leong Chean Ring [他],Ooi Toshihiko,Taguchi Seiichi
- Journal of bioscience and bioengineering 104(6), 457-463, 2007-12-25
- In our previous study, a system for producing poly(3-hydroxybutyrate) [P(3HB)] was established by introducing a polyhydroxyalkanoate (PHA) biosynthetic gene operon (phaCAB_<Re>) derived from Ral …
- NAID 110006533080
- Substrate Deacylation Mechanism of Serine beta-lactamases
- Hata Masayuki,Fujii Yasuyuki,Tanaka Yoshikazu [他],Tanaka Yoshikazu,Ishikawa Hidenori,Ishii Miho,Neya Saburo,根矢 三郎,Tsuda Minoru,津田 穣,ツダ ミノル,Hoshino Tyuji,星野 忠次
- Biological & pharmaceutical bulletin 29(11), 2151-2159, 2006-11-01
- … The rate-determining process is the tetrahedral intermediate (TI)formation and the activation energy is 24.6 kcal/mol at the DFT level. … Tyr150Oη is stabilized in the deprotonated state in the acyl-enzyme complexand works as a general base. …
- NAID 110004840384
- Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides
- Sakiyama Takaharu,Yoshimi Tsuyoshi,Miyake Akira,Umeoka Midori,Tanaka Atsushi,Ozaki Sho,Nakanishi Kazuhiro
- Memoirs of the Faculty of Engineering, Okayama University 35(1-2), 137-146, 2001-03-27
- … The purified enzyme was homogeneous on an SDS-polyacrylamide gel with a molecular mass of 59 kDa. … Itshydrolytic activity was confirmed to be specific for monoglycerides: the enzyme did not hydrolyze diandtriglycerides. … The synthetic reactionproceeded at a constant rate for approximately 24 h and reached an equilibrium after 48 h of reaction. …
- NAID 120002307705
Related Links
- rate [rāt] the speed or frequency with which an event or circumstance occurs per unit of time, population, or other standard of comparison. adjusted rate a fictitious summary rate statistically adjusted to remove the effect of a variable ...
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★リンクテーブル★
[★]
- 関
- rate-determining enzyme
[★]
- (全体に対する部分などの割合を示す)率 ⇔ (率を率で除すような比 ratioとは区別するでしょう)
- 格付けされる、等級に分けられる
- 影響力がある、重要な地位にある
- ~を値踏みする、~の価格を査定する
- (~の重要性や価値を)評価する
- (性能などによって)~を格付けする(等級に分ける)
- (金融)(不動産の)課税額を決める
- ~に値する、~の価値がある
[★]
- (げっ歯類)ラット、(マウスも含めての総称)ネズミ、ラットの
- 関
- laboratory rat、mouse、Norway rat、Rattus、Rattus norvegicus