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- 1. 有機リン剤およびカルバメート中毒organophosphate and carbamate poisoning [show details]
…dysfunction. Pralidoxime (2-PAM) and other oximes, such as HI-6 and obidoxime, are cholinesterase reactivating agents that are effective in treating both muscarinic and nicotinic symptoms . Pralidoxime should …
- 2. 化学テロ：早急な認識および初回薬物治療マネージメントchemical terrorism rapid recognition and initial medical management [show details]
…effects; pralidoxime 10 mg/kg IM or one pralidoxime 600 mg autoinjector; Severe effects – Atropine 2 to 4 mg (one or two atropine 2 mg autoinjectors); Pralidoxime 25 mg/kg (two to three pralidoxime 600 mg …
- 3. 神経筋接合部に作用する毒素の概要overview of neuromuscular junction toxins [show details]
…Specific dosing regimens are discussed separately. Pralidoxime and other oximes are effective in treating both muscarinic and nicotinic symptoms. Pralidoxime should not be administered without concurrent atropine …
- 4. 殺鼠剤中毒の概要overview of rodenticide poisoning [show details]
…the same as for other cholinesterase inhibitor poisoning and includes high doses of atropine and pralidoxime. Death occurs from severe bronchorrhea and respiratory muscle weakness, but usually only when the…
- 5. ぶどう膜黒色腫および結膜悪性黒色腫の初期マネージメントinitial management of uveal and conjunctival melanomas [show details]
English Journal
- Evaluation of the joint toxicity of chlorpyrifos ethyl and fenobucarb on climbing perch (Anabas testudineus) from rice fields in the Mekong Delta, Vietnam.
- Tam NT, Berg H, Van Cong N.
- Environmental science and pollution research international. 2018 May;25(14)13226-13234.
- Organophosphates (e.g. chlorpyrifos ethyl) and carbamates (e.g. fenobucarb) are commonly used to control a wide range of pests in rice fields of the Mekong Delta in Vietnam. This study assesses the combined effect of chlorpyrifos ethyl (CPF) and fenobucarb (F), applied at concentrations used by rice
- PMID 27250094
- An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos.
- Di Tuoro D, Portaccio M, Lepore M, Arduini F, Moscone D, Bencivenga U, Mita DG.
- New biotechnology. 2011 Dec;29(1)132-8.
- The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed. AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). When AChE is immobilized i
- PMID 21600321
- Liquid chromatography-tandem mass spectrometry method for determination of the pyridinium aldoxime 4-PAO in brain, liver, lung, and kidney.
- Sakurada K, Ohta H.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 May;878(17-18)1414-9.
- A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was validated and applied to the in vitro determination of 4-[(hydroxyimino)methyl]-1-octylpyridinium cation (4-PAO), which can penetrate the blood-brain barrier and reactivate acetylcholinesterase (AChE) inhibited by alkylphosphonat
- PMID 20138594
Japanese Journal
- 佐伯 仁,山下 敦生,名草 芳亮,岡 英男,宮内 善豊
- 蘇生 19(1), 48-51, 2000-04-20
- 自殺目的でマラソンを服毒し, 呼吸障害が長期間遷延した症例を経験した。患者は56歳男性。意識障害, 呼吸不全で来院した。硫酸アトロピン, 2-ピリジルアルドキシムメチオダイドを投与し, コリンエステラーゼ値の回復に伴い全身状態は改善したが, 間欠的に意識障害・縮瞳・血圧低下を伴った自発呼吸消失がみられ, 約2週間にわたり繰り返した。これは有機リン中毒のintermediate syndromeと考 …
- NAID 10009651945
- ANTIDOTAL ACTION OF ATROPINE SULFATE AGAINST INSECTICIDE BENFURACARB POISONING IN RATS
- ICHIKAWA Shoji,GOTO Takeshi,UMETSU Noriharu
- Journal of toxicological sciences 20(2), 143-148, 1995-05
- … The antidotal action of atropine sulfate and 2-pyridine aldoxime methiodide (2-PAM) against poisoning attributable to the new procarbamate insecticide benfuracarb [ethyl N-[2, 3-dihydro-2, 2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-isopropyl-β-alaninate] was compared utilizing rats as our experimental model. …
- NAID 110001814813
- 有機リン化合物の急性中毒に関する研究 ヒトの中毒における血清コリンエステラーゼ活性およびアイソザイムパターンの変化:ヒトの中毒における血清コリンエステラーゼ活性およびアイソザイムパターンの変化
- 山中 すみへ [他],吉田 稔,山村 行夫,西村 正雄,高江洲 義矩
- 日本衛生学雑誌 48(5), 955-965, 1993
- … Reactivation of serum ChE activity was very slow in patients treated with PAM (2-pyridine aldoxime methiodide) in the late stage of ingestion or whose symptoms reappeared.<br>3) There were no differences in the patterns of serum ChE isoenzyme by organophosphorus compound. …
- NAID 130000998050
Related Links
- Pyridine-2-aldoxime methiodide; EC Number: 202-349-6; Synonym: 2-PAM iodide, Pralidoxime iodide; find Sigma-P8755 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
- Abstract Phosphate insecticide use is increasing as is concomitant human poisoning. Home insecticide bomb as well as agricultural, crop contamination and suicidal exposure are noted. Clinical poisoning may be ...
- Aldrich-P60205; 2-Pyridinealdoxime methiodide 0.99; CAS No.: 94-63-3; Synonyms: 2-PAM; 2-PAM iodide; Pralidoxime iodide; Linear Formula: C7H11IN2O; Empirical Formula: C7H11IN2O; find related products, papers, technical ...
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