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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/21 19:12:05」(JST)
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Pteridine
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Names |
IUPAC name
pteridine
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Identifiers |
CAS Registry Number
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91-18-9 Y |
ChEBI |
CHEBI:27601 N |
ChemSpider |
1014 N |
InChI
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InChI=1S/C6H4N4/c1-2-9-6-5(8-1)3-7-4-10-6/h1-4H N
Key: CPNGPNLZQNNVQM-UHFFFAOYSA-N N
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InChI=1/C6H4N4/c1-2-9-6-5(8-1)3-7-4-10-6/h1-4H
Key: CPNGPNLZQNNVQM-UHFFFAOYAU
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Jmol-3D images |
Image |
KEGG |
C07581 N |
PubChem |
1043 |
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UNII |
6EZF26XQ81 Y |
Properties |
Chemical formula
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C6H4N4 |
Molar mass |
132.123 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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N verify (what is: Y/N?) |
Infobox references |
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Pteridine is an aromatic chemical compound composed of fused pyrimidine and pyrazine rings. A pteridine is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure. Pterins and flavins are classes of substituted pteridines that have important biological activity. Pteridine, is a precursor in the synthesis of dihydrofolic acid in many microorganisms. Pteridine and 4-Aminobenzoic acid convert by the enzyme dihydropteroate synthetase into dihydrofolic acid in the presence of glutamate. The enzyme dihydropteroate synthetase is inhibited by Sulfonamide antibiotics
See Also
- dihydrobiopterin
- tetrahydrobiopterin
References
- Voet, D.; Voet, J.G. (2004). Biochemistry (3rd ed.). John Wiley & Sons. ISBN 0-471-39223-5
External links
http://grupoargentinodefotobiologia.info/grupos/pteridinas/e_index.html
UpToDate Contents
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English Journal
- Design, synthesis and anti-HIV activity of novel quinoxaline derivatives.
- Patel SB1, Patel BD1, Pannecouque C2, Bhatt HG3.
- European journal of medicinal chemistry.Eur J Med Chem.2016 Jul 19;117:230-40. doi: 10.1016/j.ejmech.2016.04.019. Epub 2016 Apr 11.
- In order to design novel anti-HIV agents, pharmacophore modelling, virtual screening, 3D-QSAR and molecular docking studies were performed. Pharmacophore model was generated using 17 structurally diverse molecules using DISCOtech followed by refinement with GASP module of Sybyl X. The best model con
- PMID 27105027
- Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.
- Rashid U1, Sultana R2, Shaheen N3, Hassan SF4, Yaqoob F2, Ahmad MJ2, Iftikhar F2, Sultana N5, Asghar S6, Yasinzai M7, Ansari FL8, Qureshi NA9.
- European journal of medicinal chemistry.Eur J Med Chem.2016 Jun 10;115:230-44. doi: 10.1016/j.ejmech.2016.03.022. Epub 2016 Mar 14.
- In an attempt to explore novel and more potent antileishmanial compounds to diversify the current inhibitors, we pursued a medicinal chemistry-driven strategy to synthesize novel scaffolds with common pharmacophoric features of dihydropyrimidine and chalcone as current investigational antileishmania
- PMID 27017551
- Characterization of unexplored amidohydrolase enzyme-pterin deaminase.
- Jayaraman A1, Thandeeswaran M2, Priyadarsini U3, Sabarathinam S2, Nawaz KA2, Palaniswamy M4.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2016 Jun;100(11):4779-89. doi: 10.1007/s00253-016-7513-9. Epub 2016 Apr 19.
- Pterin deaminase is an amidohydrolase enzyme hydrolyzing pteridines to form lumazine derivatives and ammonia. The enzyme captured the attention of scientists as early as 1959 and had been patented for its application as an anticancer agent. It is ubiquitously present in prokaryotes and has been repo
- PMID 27094187
Japanese Journal
- Pteridine Derivatives Modified with a Guanidine for Binding and Sensing an Orphan Guanine in RNA duplexes
- Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-g]pteridines
- First Synthesis of Asperopterin A, an Isoxanthopterin Glycoside from Aspergillus Oryzae
Related Links
- Definition of PTERIDINE: a yellow crystalline bicyclic base C 6 H 4 N 4; broadly: any of a class of compounds (as the pterins) that have the bicyclic ring system of pteridine and include especially various animal pigments Ask The ...
- (těr'ĭ-dēn') Any of a group of organic compounds having two fused six-member rings each containing two nitrogen atoms and four carbon atoms. One of the rings is a pyrimidine, the other a pyrazine. Pteridines include folic acid and ...
★リンクテーブル★
[★]
- 英
- pteridine
- 関
- ジヒドロプテロイン酸
- |←dihydropteroate synthetase |-sulfonamides
- |+[グルタミン酸]]
- |←hidyrofolate reductase |-trimetoprim, methotrexate, pyrimethamine