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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/02 02:14:22」(JST)
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- 1. 高用量メトトレキサートの治療使用および毒性 therapeutic use and toxicity of high dose methotrexate
- 2. 抗マラリア剤：概要 antimalarial drugs an overview
- 3. メトトレキサートを使用した関節リウマチ治療 use of methotrexate in the treatment of rheumatoid arthritis
- 4. 低用量メトトレキサートの主な副作用 major side effects of low dose methotrexate
- 5. トリメトプリムスルファメトキサゾール：概要 trimethoprim sulfamethoxazole an overview
English Journal
- Role of methotrexate exposure in apoptosis and proliferation during early neurulation.
- Wang X1, Wang J, Guan T, Xiang Q, Wang M, Guan Z, Li G, Zhu Z, Xie Q, Zhang T, Niu B.
- Journal of applied toxicology : JAT.J Appl Toxicol.2014 Aug;34(8):862-9. doi: 10.1002/jat.2901. Epub 2013 Jul 9.
- Apoptosis and proliferation play important roles in embryonic development and are required for neural tube closure. The antifolate drug methotrexate (MTX) induces folate dysmetabolism by inhibition of dihydrofolate reductase and causes abnormal apoptosis and proliferation. In this study, we establis
- PMID 23836430
- Cover image, volume 35, issue 19.
- [No authors listed]
- Journal of computational chemistry.J Comput Chem.2014 Jul 15;35(19):i-ii. doi: 10.1002/jcc.23663.
- Recent studies have proposed that enzymes involve networks of coupled residues throughout the protein that participate in motions accompanying the chemical barrier crossing. On page 1411 (DOI: 10.1002/jcc.23629), Daniel Roston et al. use QM/MM simulations to reproduce experimental rates for the wild
- PMID 24920385
- Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer.
- Roston D1, Kohen A, Doron D, Major DT.
- Journal of computational chemistry.J Comput Chem.2014 Jul 15;35(19):1411-7. doi: 10.1002/jcc.23629. Epub 2014 May 2.
- Recent experimental and theoretical studies have proposed that enzymes involve networks of coupled residues throughout the protein that participate in motions accompanying chemical barrier crossing. Here, we have examined portions of a proposed network in dihydrofolate reductase (DHFR) using quantum
- PMID 24798860
Japanese Journal
- Binding Affinities and Protein Ligand Complex Geometries of Some Quinolylaryl α,β-unsaturated Ketones
- Hamlaoui Ikram,Boulfelfel Salah Eddine,Krid Adel,Bencharif Mustapha
- JOURNAL OF HEALTH SCIENCE 57(5), 397-400, 2011
- … We tested the affinities of six new compounds to bind to the catalytic site of the dihydrofolate reductase enzyme. … The binding modes of 1-aryl-(3-substitutedquinolyl)-prop-2-en-1-one analogues to the active site of the dihydrofolate reductase are investigated with ligand docking calculations. … Docking simulations indicated that these compounds have the same binding modes for dihydrofolate reductase as methotrexate. …
- NAID 130001151379
- Systematic alanine insertion reveals the essential regions that encode structure formation and activity of dihydrofolate reductase
- Shiba Rumi,Umeyama Mika,Tsukasa Sayaka,Kamikubo Hironari,Yamazaki Yoichi,Yamaguchi Mariko,Iwakura Masahiro,Kataoka Mikio
- BIOPHYSICS 7(0), 1-10, 2011
- … We applied this method to dihydrofolate reductase (DHFR), and examined the effects of alanine insertion on structure and the enzymatic activity by solubility assay and trimethoprim resistance, respectively. …
- NAID 130000406413
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★リンクテーブル★
| リンク元 | 「プテリジン」「ジヒドロ葉酸」 |
| 拡張検索 | 「dihydrofolate reductase」 |
「プテリジン」
- 英
- pteridine
- 関
- ジヒドロプテロイン酸
葉酸の合成
- ヒトでは3.から。
- |←dihydropteroate synthetase |-sulfonamides
- 2. ジヒドロプテロイン酸 dihydropterioic acid]]
- |+[グルタミン酸]]
- |←hidyrofolate reductase |-trimetoprim, methotrexate, pyrimethamine
「ジヒドロ葉酸」
- 英
- dihydrofolate, DHF
- 関
- 葉酸
「dihydrofolate reductase」
- 同
- DHFR
- 同
- DHFR
- 同
- DHFR
- 同
- DHFR