プロテアソーム・エンドペプチダーゼ複合体

関: 20S proteasome、proteasome

WordNet

complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
(psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior

PrepTutorEJDIC

『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/27 10:53:54」(JST)

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Proteasome endopeptidase complex (EC 3.4.25.1, ingensin, macropain, multicatalytic endopeptidase complex, prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Cleavage of peptide bonds with very broad specificity

This 20-S protein is composed of 28 subunits arranged in four rings of seven.

References

^ Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R. and Baumeister, W. (1995). "Proteasome from Thermoplasma acidophilum: a threonine protease". Science 268 (5210): 579–582. doi:10.1126/science.7725107. PMID 7725107.
^ Coux, O., Tanaka, K. and Goldberg, A.L. (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–847. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
^ Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D. and Huber, R. (1997). "Structure of 20S proteasome from yeast at 2.4Å resolution". Nature 386 (6624): 463–471. doi:10.1038/386463a0. PMID 9087403.
^ Dick, T.P., Nussbaum, A.K., Deeg, M., Heinemeyer, W., Groll, M., Schirle, M., Keilholz, W., Stevanovic, S., Wolf, D.H., Huber, R., Rammensee, H.G. and Schild, H. (1998). "Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants". J. Biol. Chem. 273 (40): 25637–25646. doi:10.1074/jbc.273.40.25637. PMID 9748229.

External links

Proteasome endopeptidase complex at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Molecular crosstalk between the proteasome, aggresomes and autophagy: translational potential and clinical implications.

Driscoll JJ, Chowdhury RD.SourceThe Vontz Center for Molecular Studies, University of Cincinnati, OH 45267-0508, United States. driscojs@uc.edu
Cancer letters.Cancer Lett.2012 Dec 28;325(2):147-54. doi: 10.1016/j.canlet.2012.06.016. Epub 2012 Jul 7.
Targeting the ubiquitin+proteasome protein degradation pathway with the therapeutic agent bortezomib has significantly improved the survival of cancer patients but drug resistance inevitably develops. Aggresomes and the autophagy pathway serve as compensatory protein-clearance mechanisms that eradic
PMID 22781397

Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells.

Yoon MJ, Kim EH, Kwon TK, Park SA, Choi KS.SourceDepartment of Molecular Science & Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443-749, Republic of Korea.
Cancer letters.Cancer Lett.2012 Nov 28;324(2):197-209. doi: 10.1016/j.canlet.2012.05.018. Epub 2012 May 22.
In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the norm
PMID 22634500

Japanese Journal

Reaction of 20S Proteasome: Shift of SDS-Dependent Activation Profile by Divalent Cations.

Yamada Shinpei,Hojo Kennichi,Yoshimura Hisashi,Ishikawa Katsutoshi
The Journal of Biochemistry 117(6), 1162-1169, 1995
… The multicatalytic endopeptidase complex (20 S proteasome) is a latent high-molecular-mass multisubunit proteinase. … In many investigations, SDS has been used as a proteasome activator at some fixed concentration that was apparently optimal. …
NAID 130003532567

Purification and Characterization of the 26S Proteasome Complex Catalyzing ATP-Dependent Breakdown of Ubiquitin-Ligated Proteins from Rat Liver.

Ugai Shin-ichi,Tamura Tomohiro,Tanahashi Nobuyuki,Takai Shigeharu,Komi Nobuhiko,Chung Chin Ha,Tanaka Keiji,Ichihara Akira
The Journal of Biochemistry 113(6), 754-768, 1993
… An ATP/ubiquitin-dependent proteasome complex with an apparent sedimentation coefficient of 26S was purified from rat liver to near homogeneity by an improved method based on procedures reported previously. … Two electrophoretically distinct forms of the 26S complex, named 26Sα and 26Sα, with very similar subunit compositions were found not only in purified preparations but also in crude extracts, indicating that the 26S proteasome is present as two isoforms. …
NAID 130003531899

「プロテアソーム・エンドペプチダーゼ複合体」

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PMC	articles
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NCBI	proteins

Proteasome endopeptidase complex
Identifiers
EC number	3.4.25.1
CAS number	140879-24-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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　　[★]

英: proteasome endopeptidase complex
関: プロテアソーム、20Sプロテアソーム

「20S proteasome」

　　[★]

20Sプロテアソーム

関: proteasome、proteasome endopeptidase complex

「complex」

　　[★]

n.

複合体、錯体、複合物、合成物、(心理)コンプレックス

adj.

複雑な、複合の

関: complexes、complicated、composite、conjugate、intricate

「complexed」

　　[★]

adj.

複合型の、混合型の

関: hybrid、mixed lineage、mixed type、mixed-type

「complexes」

　　[★]

n.

複合体

関: complex、composite

[1] Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R. and Baumeister, W. (1995). "Proteasome from Thermoplasma acidophilum: a threonine protease". Science 268 (5210): 579–582. doi:10.1126/science.7725107. PMID 7725107.

[2] Coux, O., Tanaka, K. and Goldberg, A.L. (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–847. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.

[3] Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D. and Huber, R. (1997). "Structure of 20S proteasome from yeast at 2.4Å resolution". Nature 386 (6624): 463–471. doi:10.1038/386463a0. PMID 9087403.

[4] Dick, T.P., Nussbaum, A.K., Deeg, M., Heinemeyer, W., Groll, M., Schirle, M., Keilholz, W., Stevanovic, S., Wolf, D.H., Huber, R., Rammensee, H.G. and Schild, H. (1998). "Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants". J. Biol. Chem. 273 (40): 25637–25646. doi:10.1074/jbc.273.40.25637. PMID 9748229.

リンク元	「プロテアソーム・エンドペプチダーゼ複合体」「20S proteasome」
関連記事	「complex」「complexed」「complexes」

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案内

proteasome endopeptidase complex