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1. 再発性または難治性多発性骨髄腫の治療 treatment of relapsed or refractory multiple myeloma
2. 癌における悪液質の病因、臨床的特徴および評価 pathogenesis clinical features and assessment of cancer cachexia
3. アントラサイクリン系以外の癌化学療法剤の心毒性 cardiotoxicity of nonanthracycline cancer chemotherapy agents
4. フォンヒッペル・リンダウ病の分子生物学および病因 molecular biology and pathogenesis of von hippel lindau disease
5. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease

English Journal

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis.

Prause J, Goswami A, Katona I, Roos A, Schnizler M, Bushuven E, Dreier A, Buchkremer S, Johann S, Beyer C, Deschauer M, Troost D, Weis J.SourceThese authors contributed equally to this work.
Human molecular genetics.Hum Mol Genet.2013 Apr 15;22(8):1581-600. doi: 10.1093/hmg/ddt008. Epub 2013 Jan 11.
Intracellular accumulations of mutant, misfolded proteins are major pathological hallmarks of amyotrophic lateral sclerosis (ALS) and related disorders. Recently, mutations in Sigma receptor 1 (SigR1) have been found to cause a form of ALS and frontotemporal lobar degeneration (FTLD). Our goal was t
PMID 23314020

Chronic aspirin via dose-dependent and selective inhibition of cardiac proteasome possibly contributed a potential risk to the ischemic heart.

Tan C, Chen W, Wu Y, Lin J, Lin R, Tan X, Chen S.SourceFujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fujian China. Electronic address: tchunj@126.com.
Experimental gerontology.Exp Gerontol.2013 Apr 5. pii: S0531-5565(13)00098-3. doi: 10.1016/j.exger.2013.03.012. [Epub ahead of print]
Impaired cardiac proteasome has been reported in ischemic heart and heart failure. Recent data highlighted aspirin as an inhibitor of the ubiquitin-proteasome system, however, it's unclear whether it affects cardiac proteasome functions. Myocardial infarction (MI), sham or normal male SD rats were i
PMID 23567078

Miles EL, O'Gorman C, Zhao J, Samuel M, Walters E, Yi YJ, Sutovsky M, Prather RS, Wells KD, Sutovsky P.SourceDivision of Animal Sciences, National Swine Resource and Research Center, and Departments of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO 65211.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Apr 2. [Epub ahead of print]
Among its many functions, the ubiquitin-proteasome system regulates substrate-specific proteolysis during the cell cycle, apoptosis, and fertilization and in pathologies such as Alzheimer's disease, cancer, and liver cirrhosis. Proteasomes are present in human and boar spermatozoa, but little is kno
PMID 23550158

Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein gene.

Makino Akiko,Fujino Kan,Parrish Nicholas F,Honda Tomoyuki,Tomonaga Keizo
Scientific reports 5, 2015-03-03
… The 20S proteasome assay showed that BDV-N and BDV-N-derived peptide inhibited the processing of NF-κB1 p105 into p50. … These results suggest BDV-N inhibits NF-κB1 processing by the 20S proteasome through its ankyrin-like peptide sequence, resulting in the suppression of IKK/NF-κB pathway activation. …
NAID 120005575162

Possible Role of ZPAC, Zygote-specific Proteasome Assembly Chaperone, During Spermatogenesis in the Mouse

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Journal of Reproduction and Development 60(3), 179-186, 2014
… In the mammalian testis, the ubiquitin-proteasome system plays important roles in the process that promotes the formation of mature sperm. … We recently identified zygote-specific proteasome assembly chaperone (ZPAC), which is specifically expressed in the mouse gonads and zygote. … ZPAC mediates a unique proteasome assembly pathway in the zygote, but the expression profile and function of ZPAC in the testis is not fully understood. …
NAID 130003390828