硫酸プロタミン試験
WordNet
- undergo a test; "She doesnt test well"
- any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
- the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
- the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
- a hard outer covering as of some amoebas and sea urchins
- put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
- achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
- determine the presence or properties of (a substance)
- show a certain characteristic when tested; "He tested positive for HIV"
- an examination of the characteristics of something; "there are laboratories for commercial testing"; "it involved testing thousands of children for smallpox"
- the act of subjecting to experimental test in order to determine how well something works; "they agreed to end the testing of atomic weapons"
- convert into a sulfate
- a salt or ester of sulphuric acid (同)sulphate
- tested and proved useful or correct; "a tested method" (同)tried, well-tried
- tested and proved to be reliable (同)time-tested, tried, tried and true
- a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
PrepTutorEJDIC
- (人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
UpToDate Contents
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English Journal
- Sustained-release protamine sulphate-impregnated microspheres may reduce the frequent administration of recombinant interferon α-2b in ovarian cancer: in-vitro characterization.
- Gulia M1, Rai S, Jain UK, Katare OP, Katyal A, Madan J.Author information 1aDepartment of Pharmaceutics, Chandigarh College of Pharmacy, Mohali, Panjab bDr B.R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi cUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.AbstractParenteral administration of recombinant interferon-α-2b (rINF-α-2b) at a dose of 50×10 IU once a week for 8 weeks is recommended for ovarian cancer. However, short half-life, small therapeutic index and proteolytic degradation cause fluctuations in plasma level and pose barriers in the development of a clinically viable dosage form. Therefore, in the present investigation, fluorescein isothiocynate-tagged rINF-α-2b was loaded into stearic acid (*rINF-α-2b-SMs), pectin (*rINF-α-2b-PMs) and gelatin (*rINF-α-2b-GMs) microspheres. Parameters such as particle size, ζ potential, encapsulation efficiency and in-vitro release were studied to follow the optimization process. The formulation, *rINF-α-2b-GMs of particle size 8.3±2.1 μm with an encapsulation efficiency of 76.0±7.4%, offered 97.4% of *rINF-α-2b release at 288 h. Thus, negatively charged extended-release formulation *rINF-α-2b-GMs was then tethered with a gradient concentration (5-20 mg/ml) of a cationic arginine-rich protein stabilizer, protamine sulphate (Pt). The nanoformulation, *rINF-α-2b-Pt-GMs-15 superimposed with 15 mg/ml of Pt, released 95.0% of *rINF-α-2b at 336 h and was designated as the optimized formulation. The optimized formulation also conserved the primary and secondary structure of *rINF-α-2b as analysed by gel electrophoresis and circular dichroism. Moreover, in-vitro cytotoxicity analysis of SKOV3 cells of the optimized nanoformulation reported significantly (one-way analysis of variance test, P<0.05) lower IC50 (414.3 IU/ml) compared with *rINF-α-2b-GMs (514.3 IU/ml) and pure rINF-α-2b (628.6 IU/ml) at 72 h by offering a prolonged cytotoxic effect. Therefore, *rINF-α-2b-Pt-GMs-15, a promising nanomedicine, warrants further in-depth in-vivo study to scale up the technology for clinical translation.
- Anti-cancer drugs.Anticancer Drugs.2014 Jan;25(1):63-71. doi: 10.1097/CAD.0000000000000026.
- Parenteral administration of recombinant interferon-α-2b (rINF-α-2b) at a dose of 50×10 IU once a week for 8 weeks is recommended for ovarian cancer. However, short half-life, small therapeutic index and proteolytic degradation cause fluctuations in plasma level and pose barriers in the developme
- PMID 24052106
- Using Protamine Can Significantly Reduce the Incidence of Bleeding Complications after Carotid Endarterectomy without Increasing the Risk of Ischemic Cerebral Events.
- Mazzalai F1, Piatto G, Toniato A, Lorenzetti R, Baracchini C, Ballotta E.Author information 1Vascular Surgery Group, 2nd Surgical Clinic, Department of Surgical, Oncological, and Gastroenterological Sciences, School of Medicine, University of Padua, Ospedale Giustinianeo, 2nd Floor, Via N. Giustiniani, 2, 35128, Padua, Italy.AbstractBACKGROUND: Controversy persists regarding the use of protamine sulfate (PS) during carotid endarterectomy (CEA), chiefly because of conflicting experiences reporting both less bleeding and a higher stroke risk. The goal of the present study was to test the hypothesis that reversing heparin with PS after CEA significantly reduces the incidence of bleeding complications without increasing the risk of postoperative stroke.
- World journal of surgery.World J Surg.2013 Nov 26. [Epub ahead of print]
- BACKGROUND: Controversy persists regarding the use of protamine sulfate (PS) during carotid endarterectomy (CEA), chiefly because of conflicting experiences reporting both less bleeding and a higher stroke risk. The goal of the present study was to test the hypothesis that reversing heparin with PS
- PMID 24276985
- Protamine-induced immune thrombocytopenia.
- Singla A1, Sullivan MJ, Lee G, Bartholomew J, Kapadia S, Aster RH, Curtis BR.Author information 1Cleveland Clinic Foundation, Cleveland, Ohio; Platelet & Neutrophil Immunology Laboratory, Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin; Division of Hematology, Duke University Medical Center, Durham, North Carolina; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.AbstractBACKGROUND: Protamine is widely used to reverse the anticoagulant effects of heparin. Although mild thrombocytopenia is common in patients given protamine after cardiac procedures, acute severe thrombocytopenia has not been described. We encountered a patient who experienced profound thrombocytopenia and bleeding shortly after administration of protamine and performed studies to characterize the responsible mechanism.
- Transfusion.Transfusion.2013 Oct;53(10):2158-63. doi: 10.1111/trf.12112. Epub 2013 Feb 5.
- BACKGROUND: Protamine is widely used to reverse the anticoagulant effects of heparin. Although mild thrombocytopenia is common in patients given protamine after cardiac procedures, acute severe thrombocytopenia has not been described. We encountered a patient who experienced profound thrombocytopeni
- PMID 23384227
Japanese Journal
- High-Throughput Turbidimetric Screening for Heparin-Neutralizing Agents and Low-Molecular-Weight Heparin Mimetics
- Sekiya Atsushi,Oishi Shinya,Fujii Nobutaka,Koide Takaki
- Chemical and Pharmaceutical Bulletin 60(3), 371-376, 2012
- … Safer heparin-neutralizing agents are currently required to replace protamine, the use of which causes adverse effects such as anaphylaxia. … The assay is based on turbidimetric measurement of a solution of collagen, heparin, and a test compound. … Since this assay protocol is feasible for an automated high-throughput screening (HTS) system, it could enhance the lead seeking process for drugs related to heparin/heparan sulfate (HS) functions. …
- NAID 130001852423
- Polycationic protamine for water-insoluble complex formation with DNA
- FUKUSHIMA Tadao,OHNO Jun,HAYAKAWA Tohru,IMAYOSHI Rieko,KAWAGUCHI Minoru,DOI Yutaka,KANAYA Keiichi,MITARAI Makoto
- Dental materials journal 29(5), 529-535, 2010-09-01
- … The DNA/protamine complex was prepared by a reaction between DNA and protamine sulfate solutions with stirring, and its cell viability, antibacterial effect and histopathological responses were examined. … A water-insoluble white powder, DNA/protamine complex, with a porous structure was obtained. …
- NAID 10026669680
Related Links
- The serial dilution protamine sulfate test for the detection of fibrin monomer and fibrin degradation products. J Lab Clin Med. 1971 Apr; 77 (4):665–676. [PubMed] Articles from California Medicine are provided here courtesy of ...
- protamine sulfate test When the proper combination of abnormal laboratory results and patient symptoms exists, a negative protamine sulfate test suggests primaryfibrinolysis.Problems of diagnosis of d… Hébergé par OverBlog
★リンクテーブル★
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- 英
- protamine sulfate test
- 同
- パラコアグレーションテスト paracoagulation test
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- 英
- protamine sulfate test
- 同
- パラコアグレーションテスト paracoagulation test
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- 関
- H2SO4、inorganic sulfate、sulfate ester、sulfated、sulfation、sulfuric acid、sulfuric acid ester、sulphate、sulphuric acid
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- 関
- assessment、data quality、exam、examination、examine、experimental design、matched group、measurement、research design、scoring method、test、trial
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- 関
- sulfate、sulfation、sulphate
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テスト
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スルファ、サルファ