WordNet

a rare abnormality marked by premature aging (grey hair and wrinkled skin and stooped posture) in a child
born after a gestation period of less than the normal time; "a premature infant"
uncommonly early or before the expected time; "illness led to his premature death"; "alcohol brought him to an untimely end" (同)untimely
the state of being senile

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1. 早期副腎皮質性第二次性徴 premature adrenarche
2. 心室性期外収縮 ventricular premature beats
3. 妊娠中期の前期破水による早産 midtrimester preterm premature rupture of membranes
4. 上室性期外収縮 supraventricular premature beats
5. 早産児のための母乳の栄養組成および人工乳 nutritional composition of human milk and preterm formula for the premature infant

Cigarette Smoking and Mortality in Adults Aged 70 Years and Older: Results From the NIH-AARP Cohort.

Nash SH1, Liao LM2, Harris TB3, Freedman ND2.
American journal of preventive medicine.Am J Prev Med.2017 Mar;52(3):276-283. doi: 10.1016/j.amepre.2016.09.036. Epub 2016 Nov 30.
INTRODUCTION: Tobacco use remains a leading modifiable cause of cancer incidence and premature mortality in the U.S. and globally. Despite increasing life expectancy worldwide, less is known about the effects of cigarette smoking on older populations. This study sought to determine the effects of sm
PMID 27914770

Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses.

Christoffersen M1, Frikke-Schmidt R2, Nordestgaard BG3, Tybjærg-Hansen A4.
Experimental gerontology.Exp Gerontol.2017 Mar;89:69-77. doi: 10.1016/j.exger.2017.01.005. Epub 2017 Jan 4.
BACKGROUND: Werner syndrome, a premature genetic aging syndrome, shares many clinical features reminiscent of normal physiological aging, and ischemic vascular disease is a frequent cause of death. We tested the hypothesis that genetic variation in the WRN gene was associated with risk of ischemic v
PMID 28063943

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.

Bar DZ1, Arlt MF2, Brazier JF3, Norris WE4, Campbell SE3, Chines P1, Larrieu D5, Jackson SP5, Collins FS1, Glover TW2, Gordon LB4,6.
Journal of medical genetics.J Med Genet.2017 Mar;54(3):212-216. doi: 10.1136/jmedgenet-2016-104295. Epub 2016 Dec 5.
BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a fatal sporadic autosomal dominant premature ageing disease caused by single base mutations that optimise a cryptic splice site within exon 11 of the LMNA gene. The resultant disease-causing protein, progerin, acts as a dominant negative. D
PMID 27920058