WordNet

a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs" (同)antibiotic drug
of or relating to antibiotic drugs

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抗生物質(ペニシリン,ストレプトマイシンなど) / 抗生[物質]の

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1. マクロライド系剤、アミノグリコシド、テトラサイクリン、クリンダマイシン、およびメトロニダゾールに対する過敏反応 hypersensitivity reactions to macrolides aminoglycosides tetracyclines clindamycin and metronidazole
2. 成人の外来患者における市中肺炎の治療 treatment of community acquired pneumonia in adults in the outpatient setting
3. 慢性肺アスペルギルス症の治療 treatment of chronic pulmonary aspergillosis
4. 自由生活アメーバ free living amebas
5. 腎移植における哺乳動物ラパマイシン標的蛋白質（mTOR）阻害剤 mammalian target of rapamycin mtor inhibitors in renal transplantation

English Journal

Isolation of a new broad spectrum antifungal polyene from Streptomyces sp. MTCC 5680.

Vartak A1, Mutalik V, Parab RR, Shanbhag P, Bhave S, Mishra PD, Mahajan GB.Author information 1Department of Natural products-Biology, Piramal Enterprises Limited, Mumbai, India.AbstractA new polyene macrolide antibiotic PN00053 was isolated from the fermentation broth of Streptomyces sp. wild-type strain MTCC-5680. The producer strain was isolated from fertile mountain soil of Naldehra region, Himachal Pradesh, India. The compound PN00053 was purified through various steps of chromatographic techniques and bio-activity guided fractionation followed by its characterization using physiochemical properties, spectral data (1 H-NMR, 13 C-NMR, HMBC, HSQC, and COSY) and MS analysis. PN00053 exhibited broad spectrum in vitro antifungal activity against strains of Aspergillus fumigatus (HMR), A. fumigatus ATCC 16424, Candida albicans (I.V.), C. albicans ATCC 14503, C. krusei GO6, C. glabrata HO4, Cryptococcus neoformans, Trichophyton sp. as well as fluconazole resistant strains C. krusei GO3 and C. glabrata HO5. It did not inhibit growth of gram positive and gram-negative bacteria, displaying its specificity against fungi.
Letters in applied microbiology.Lett Appl Microbiol.2014 Feb 12. doi: 10.1111/lam.12229. [Epub ahead of print]
A new polyene macrolide antibiotic PN00053 was isolated from the fermentation broth of Streptomyces sp. wild-type strain MTCC-5680. The producer strain was isolated from fertile mountain soil of Naldehra region, Himachal Pradesh, India. The compound PN00053 was purified through various steps of chro
PMID 24517845

Didehydroroflamycoin pentaene macrolide family from Streptomyces durmitorensis MS405(T) : production optimization and antimicrobial activity.

Stankovic N1, Senerovic L, Bojic-Trbojevic Z, Vuckovic I, Vicovac L, Vasiljevic B, Nikodinovic-Runic J.Author information 1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.AbstractAIMS: The aim of this study was to improve production of pentaene 32,33-didehydroroflamycoin (DDHR) in Streptomyces durmitorensis MS405 strain to obtain quantities sufficient for in depth analysis of antimicrobial properties.
Journal of applied microbiology.J Appl Microbiol.2013 Dec;115(6):1297-306. doi: 10.1111/jam.12326. Epub 2013 Sep 2.
AIMS: The aim of this study was to improve production of pentaene 32,33-didehydroroflamycoin (DDHR) in Streptomyces durmitorensis MS405 strain to obtain quantities sufficient for in depth analysis of antimicrobial properties.METHODS AND RESULTS: Through classical medium optimization conditions for s
PMID 23941529

All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities.

Jhunjhunwala S1, Chen LC, Nichols EE, Thomson AW, Raimondi G, Little SR.Author information 13.720 Rutland Ave, Room 755A, Baltimore, MD 21205, USA. g.raimondi@jhmi.edu or University of Pittsburgh, 3700 O'Hara St., 440 Benedum Hall, Pittsburgh, PA 15261, USA. E-mail: srlittle@pitt.edu; Twitter: http://www.twitter.com/@think_little.AbstractTregs play important roles in maintaining immune homeostasis, and thus, therapies based on Treg are promising candidates for the treatment for a variety of immune-mediated disorders. These therapies, however, face the significant challenge of obtaining adequate numbers of Tregs from peripheral blood that maintains suppressive function following extensive expansion. Inducing Tregs from non-Tregs offers a viable alternative. Different methods to induce Tregs have been proposed and involve mainly treating cells with TGF-β-iTreg. However, use of TGF-β alone is not sufficient to induce stable Tregs. ATRA or rapa has been shown to synergize with TGF-β to induce stable Tregs. Whereas TGF-β plus RA-iTregs have been well-described in the literature, the phenotype, function, and migratory characteristics of TGF-β plus rapa-iTreg have yet to be elucidated. Herein, we describe the phenotype and function of mouse rapa-iTreg and reveal that these cells differ in their in vivo homing capacity when compared with mouse RA-iTreg and mouse TGF-β-iTreg. This difference in migratory activity significantly affects the therapeutic capacity of each subset in a mouse model of colitis. We also describe the characteristics of iTreg generated in the presence of TGF-β, RA, and rapa.
Journal of leukocyte biology.J Leukoc Biol.2013 Nov;94(5):981-9. doi: 10.1189/jlb.0312167. Epub 2013 Jul 29.
Tregs play important roles in maintaining immune homeostasis, and thus, therapies based on Treg are promising candidates for the treatment for a variety of immune-mediated disorders. These therapies, however, face the significant challenge of obtaining adequate numbers of Tregs from peripheral blood
PMID 23898044

Japanese Journal

New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis

STODULKOVA Eva,KUZMA Marek,HENCH Ivana Bratic,CERNY Jan,KRALOVA Jarmila,NOVAK Petr,CHUDICKOVA Milada,SAVIC Miloje,DJOKIC Lidija,VASILJEVIC Branka,FLIEGER Miroslav
Journal of antibiotics
NAID 10030640633

Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A_1 (S44HP)

PREOBRAZHENSKAYA Maria N,OLSUFYEVA Eugenia N,TEVYASHOVA Anna N,PRINTSEVSKAYA Svetlana S,SOLOVIEVA Svetlana E,REZNIKOVA Marina I,TRENIN Aleksey S,GALATENKO Olga A,TRESHALIN Ivan D,PEREVERZEVA Eleonora R,MIRCHINK Elena P,ZOTCHEV Sergey B
Journal of antibiotics
NAID 10030707571

アムホテリシンB封入イムノリポソーム

丸山一雄,滝澤知子,鈴木亮 [他],宇都口直樹
Drug delivery system 21(5), 516-522, 2006-09-10
ポリエンマクロライド系抗真菌剤であるアムホテリシンB (AmB) は, 深在性真菌症の治療に用いられているが, 腎障害などの重篤な副作用を示すため, その使用に制限がある. したがって, DDSによる副作用の軽減が望まれている. AmBは水やほとんどの有機溶媒に不溶なため, そのリポソーム化は困難であったが, ポリエチレングリコールのリン脂質誘導体 (DSPE-PEG) と9% sucroseを用 …
NAID 10020625892

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リンク元	「ポリエンマクロライド系抗生物質」
関連記事	「macrolide」「macrolide antibiotics」「polyene」「polyene macrolide」「macrolides」