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1. マクロライド系剤、アミノグリコシド、テトラサイクリン、クリンダマイシン、およびメトロニダゾールに対する過敏反応 hypersensitivity reactions to macrolides aminoglycosides tetracyclines clindamycin and metronidazole
2. 嚢胞性線維症：肺疾患治療の概要 cystic fibrosis overview of the treatment of lung disease
3. 成人の外来患者における市中肺炎の治療 treatment of community acquired pneumonia in adults in the outpatient setting
4. 慢性肺アスペルギルス症の治療 treatment of chronic pulmonary aspergillosis
5. 自由生活アメーバ free living amebas

English Journal

Japanese Journal

Enhancement of metabolic flux toward ε-poly-[L]-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus

Yamanaka Kazuya,Hamano Yoshimitsu,Oikawa Tadao
Journal of bioscience and bioengineering 129(5), 558-564, 2020-05
NAID 40022231021

The genome sequence of Streptomyces rochei 7434AN4, which carries a linear chromosome and three characteristic linear plasmids

Nindita Yosi,Cao Zhisheng,Fauzi Amirudin Akhmad,Teshima Aiko,Misaki Yuya,Muslimin Rukman,Yang Yingjie,Shiwa Yuh,Yoshikawa Hirofumi,Tagami Michihira,Lezhava Alexander,Ishikawa Jun,Kuroda Makoto,Sekizuka Tsuyoshi,Inada Kuninobu,Kinashi Haruyasu,Arakawa Kenji
Scientific Reports (9), 10973, 2019-07-29
… rochei chromosome harbors at least 35 secondary metabolite biosynthetic gene clusters, including those for the 28-membered polyene macrolide pentamycin and the azoxyalkene compound KA57-A. …
NAID 120006731228

分子間距離情報に基づくアンフォテリシンB－エルゴステロール相互作用様式の解析

梅川雄一,中川泰男,松下直広,土川博史,花島慎弥,大石徹,松森信明,村田道雄
天然有機化合物討論会講演要旨集 57(0), Oral9, 2015
<p>　アンフォテリシンB(AmB, 図1a)は放線菌Streptomyces nodosusの生産するポリエンマクロライド化合物であり、その強力な抗カビ活性と耐性のできにくい性質から、現在でも抗真菌薬として広く用いられている。AmBの活性は細胞膜中に形成されるイオン透過性チャネル(図1-b)に起因するとされており<sup>1)</sup>、また選択毒性はチャネ …
NAID 130007491907

Related Links

The polyene macrolide antibiotics.

Polyene macrolide derivatives. I. N-acylation and esterification reactions with amphotericin B. J Antibiot (Tokyo) 1972 Apr; 25 (4):256–258. [] Palacios J, Serrano R. Proton permeability induced by polyene antibiotics. A plausible 91 ...

Polyene Macrolide Antibiotics - Pharmacology - Veterinary ...

The polyene macrolides have been isolated from various strains of bacteria; amphotericin B is an antibiotic product of Streptomyces nodosus. Amphotericin B, nystatin, and pimaricin (natamycin) are the only polyene macrolide antibiotics used in veterinary medicine. The polyenes are poorly soluble in water and the common organic solvents.

Chemistry and biology of the polyene macrolide antibiotics.

Polyene macrolide derivatives. 3. Biological properties of polyene macrolide ester salts. J Antibiot (Tokyo) 1972 Apr; 25 (4):261–262. [] Borowski E, Malyshkina M, Kotienko T, Soloviev S. Mycoheptin, a new member of non 1964; 9 ...