関: PKD、polycystic kidney、polycystic kidney disease

WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)
腎臓の

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1. 常染色体優性多発性嚢胞腎の診断およびスクリーニング diagnosis of and screening for autosomal dominant polycystic kidney disease
2. 常染色体優性多発性嚢胞腎の経過および治療 course and treatment of autosomal dominant polycystic kidney disease
3. 常染色体優性多発性嚢胞腎の腎症状 renal manifestations of autosomal dominant polycystic kidney disease
4. 小児における常染色体劣性多発性嚢胞腎 autosomal recessive polycystic kidney disease in children
5. 嚢胞性腎疾患の胎児超音波診断 prenatal sonographic diagnosis of cystic renal disease

English Journal

Transforming growth factor-β inhibits cystogenesis in human autosomal dominant polycystic kidney epithelial cells.

Elberg D, Jayaraman S, Turman MA, Elberg G.AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and characterized by the formation of multiple fluid-filled cysts in the kidneys. It is believed that environmental factors may play an important role in the disease progression. However, the molecular identity of autocrine/paracrine factors influencing cyst formation is largely unknown. In this study, we identified transforming growth factor-β2 (TGF-β2) secreted by normal human kidney (NHK) and ADPKD cells as an inhibitor of cystogenesis in 3D culture system using ADPKD cells from human kidneys. TGF-β2 was identified in conditioned media (CM) of NHK and ADPKD cells as a latent factor activated by heat in vitro. While all TGF-β isoforms recombinant proteins (TGF-β1, -β2, or -β3) displayed a similar inhibitory effect on cyst formation, TGF-β2 was the predominant isoform detected in CM. The involvement of TGF-β2 in the suppression of cyst formation was demonstrated by using a TGF-β2 specific blocking antibody and a TGF-β receptor I kinase inhibitor. TGF-β2 inhibited cyst formation by a mechanism other than activation of p38 mitogen-activated protein (MAP) kinase that mediated cell death in ADPKD cells. Further, we found that TGF-β2 modulated expression of various genes involved in cell-cell and cell-matrix interactions and extracellular matrix proteins that may play a role in the regulation of cystogenesis. Collectively, our results suggest that TGF-β2 secreted by renal epithelial cells may be an inhibitor of cystogenesis influencing the progression of ADPKD.
Experimental cell research.Exp Cell Res.2012 Aug 1;318(13):1508-16. Epub 2012 Mar 30.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and characterized by the formation of multiple fluid-filled cysts in the kidneys. It is believed that environmental factors may play an important role in the disease progression. However, the mo
PMID 22504005

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.

Natoli TA, Husson H, Rogers KA, Smith LA, Wang B, Budman Y, Bukanov NO, Ledbetter SR, Klinger KW, Leonard JP, Ibraghimov-Beskrovnaya O.SourceThese authors contributed equally to this work.
Human molecular genetics.Hum Mol Genet.2012 Aug 1;21(15):3397-407. Epub 2012 May 4.
Genetic forms of polycystic kidney diseases (PKDs), including nephronophthisis, are characterized by formation of fluid-filled cysts in the kidneys and progression to end-stage renal disease. No therapies are currently available to treat cystic diseases, making it imperative to dissect molecular mec
PMID 22563011

Japanese Journal

Renal disease progression in autosomal dominant polycystic kidney disease

HIGASHIHARA Eiji,HORIE Shigeo,MUTO Satoru,MOCHIZUKI Toshio,NISHIO Saori,NUTAHARA Kikuo
Clinical and experimental nephrology 16(4), 622-628, 2012-08-01
NAID 10031058310

A potential salvage therapy for refractory renal cyst infection in patients with autosomal dominant polycystic kidney disease

YANG Chih-Chao,CHUANG Feng-Rong,CHEN Jin-Bor,LEE Chien-Te,WU Chien-Hsing
Clinical and experimental nephrology 16(1), 183-184, 2012-02-01
NAID 10030343388

Ciliopathy

中西浩一,吉川徳茂
日本小児腎臓病学会雑誌 25(2), 127-131, 2012
… As cilia are a component of almost all vertebrate cells, cilia dysfunction can manifest as a constellation of features that include characteristically, retinal degeneration, renal disease and cerebral anomalies. …
NAID 130003346839