English Journal

Effects of L-carnosine and its zinc complex (polaprezinc) on pressure ulcer healing.

Sakae K, Agata T, Kamide R, Yanagisawa H.SourceHiroyuki Yanagisawa, Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan. Email: hryanagisawa@jikei.ac.jp.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.Nutr Clin Pract.2013 Oct;28(5):609-16. doi: 10.1177/0884533613493333. Epub 2013 Jul 8.
Background: L-carnosine (CAR) is an endogenous dipeptide. We aimed to determine the effects of CAR and its zinc complex polaprezinc (PLZ) on pressure ulcer healing in institutionalized long-term care patients. Methods: This study was a nonrandomized controlled trial with a maximum 4-week follow-up.
PMID 23835365

Zinc-L-carnosine binds to molecular chaperone HSP70 and inhibits the chaperone activity of the protein.

Haga A, Okamoto T, Yamada S, Kubota T, Sanpei A, Takahashi S, Nakayama M, Nagai M, Otaka M, Miyazaki T, Nunomura W, Grave E, Itoh H.SourceDepartment of Life Science, Graduate School and Faculty of Engineering and Resource Science, Akita University, Akita 010-8502, Japan and Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo-Ku, Tokyo 113-8421, Japan.
Journal of biochemistry.J Biochem.2013 Sep;154(3):249-56. doi: 10.1093/jb/mvt041. Epub 2013 May 17.
In this study, we have investigated the specific binding proteins of Zinc-l-carnosine (Polaprezinc) using Polaprezinc-affinity column chromatography in vitro. A protein having a 70-kDa molecular mass was eluted by the linear gradient of 0-1.0 mM Polaprezinc from the affinity column and the protein w
PMID 23687308

The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide.

Choi HS, Lim JY, Chun HJ, Lee M, Kim ES, Keum B, Seo YS, Jeen YT, Um SH, Lee HS, Kim CD, Ryu HS, Sul D.SourceDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Republic of Korea.
Life sciences.Life Sci.2013 Jul 30;93(2-3):69-77. doi: 10.1016/j.lfs.2013.05.019. Epub 2013 Jun 3.
AIMS: Polaprezinc (PZ), which consists of l-carnosine and zinc, is widely used to treat gastric ulcers. We compared the effects of PZ with those of rebamipide (RM) on the expression of inflammatory cytokines, antioxidants, growth factors, and heat shock proteins (HSP) in a rat model.MAIN METHODS: Se
PMID 23743168

Japanese Journal

Different effects of polaprezinc and zinc chloride on zinc supplementation in elderly bedridden patients receiving enteral nutrition

Oidov Batgerel,Sakamoto Hironosuke,Kawada Etsuo,Morita Toyoho,Ohyama Yoshio,Koyama Hiroshi,Tamura Jun'ichi
The Kitakanto medical journal 61(3), 275-280, 2011-08-01
… Aims : The purposes of this study were to compare the efTects of polaprezinc and zinc chloride on serumzinc and copper concentrations in elderly bedridden patients receiving enteral nutrition, and to examinethe efTects of polaprezinc on pressure ulcer healing in those patients. … Then, another five elderly patients with pressureulcers were treated with polaprezinc for 8 weeks. …
NAID 120003290150