WordNet
- the property of sticking together (as of glue and wood) or the joining of surfaces of different composition; "the mutual adhesiveness of cells"; "a heated hydraulic press was required for adhesion" (同)adhesion, adherence, bond
- tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/08 18:41:48」(JST)
[Wiki en表示]
Platelet adhesiveness refers to the processes or factors which lead to the adhesion of platelets to other structures.[1]
It can be contrasted with platelet aggregation,[2] which refers to the processes or factors which lead to the adhesion of platelets to other platelets.
See also
- Platelet membrane glycoprotein
References
- ^ Platelet adhesiveness at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Mimidis K, Papadopoulos V, Kartasis Z, et al. (May 2004). "Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system". JOP 5 (3): 132–7. PMID 15138334.
Myeloid physiology
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Hematopoiesis |
Myelopoiesis
(CFU-GEMM)
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CFU-GM
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Granulopoiesis (Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, Band cell)
Monocytopoiesis (Monoblast, Promonocyte)
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MEP
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Thrombopoiesis (Megakaryoblast, Promegakaryocyte)
Erythropoiesis (Proerythroblast, Normoblast, Reticulocyte)
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General
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Extramedullary hematopoiesis
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Hemostasis |
Coagulation (Fibrinolysis) · Clot retraction · Platelet adhesiveness
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Other |
Erythrocyte aggregation
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells.
- Goel PN1, Gude RP2.Author information 1Gude Lab, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410210, India. Electronic address: peeyushgoel29@gmail.com.2Gude Lab, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410210, India. Electronic address: rajivgude@yahoo.in.AbstractPentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Being an inhibitor of platelet aggregation, it can thus reduce the adhesiveness of cancer cells prolonging their circulation time. This delay in forming secondary tumours makes them more prone to immunological surveillance. Recently, we have evaluated its anti-metastatic efficacy against breast cancer, using MDA-MB-231 model system. In view of this, we had ascertained the effect of PTX on adhesion of MDA-MB-231 cells to extracellular matrix components (ECM) and its allied receptors such as the integrins. PTX affected adhesion of breast cancer cells to matrigel, collagen type IV, fibronectin and laminin in a dose dependent manner. Further, PTX showed a differential effect on integrin expression profile. The experimental metastasis model using NOD-SCID mice showed lesser tumour island formation when treated with PTX compared to the control. These findings further substantiate the anti-adhesive potential of PTX in breast cancer and warrant further insights into the functional regulation.
- Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.Biomed Pharmacother.2014 Feb;68(1):93-9. doi: 10.1016/j.biopha.2013.09.002. Epub 2013 Oct 8.
- Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Being an inhibitor of platelet aggregation, it can thus reduce the adhesiveness of cancer cells prolonging their circulation time. This delay in forming secondary tumours makes them more prone t
- PMID 24269001
- Desmopressin (DDAVP) improves recruitment of activated platelets to collagen but simultaneously increases platelet endothelial interactions in vitro.
- Calmer S, Ferkau A, Larmann J, Johanning K, Czaja E, Hagl C, Echtermeyer F, Goudeva L, Heuft HG, Theilmeier G.Author information Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School , Hannover , Germany.AbstractPlatelet dysfunction can cause clinically relevant bleeding. Treatment with DDAVP is advocated for this condition. DDAVP increases von Willebrand factor (VWF) on endothelial cells (ECs) and in plasma. VWF could facilitate platelet deposition on subendothelial collagen. VWF also facilitates platelet/EC interactions. Therefore DDAVP could precipitate thromboembolic events. We used a flow chamber model to study in vitro and ex vivo if DDAVP alters recruitment of platelets to EC and collagen. Resting or TRAP-activated platelets and EC were treated individually or simultaneously with 0.4 ng/ml DDAVP. Fluorophor-labeled platelets (10(6)/ml) were resuspended in reconstituted blood and superfused across EC and collagen in an in vitro flow chamber model at arterial shear (320 s(-1)). Adhesion of platelets to the respective surface was recorded fluorescence microscopically and platelet covered area was assessed. TRAP significantly induced adhesiveness of platelets for collagen and EC. DDAVP pretreatment of platelets did not affect adhesiveness of resting or TRAP-activated platelets for collagen or EC. Adhesiveness of resting but not TRAP-activated platelets was induced on DDAVP-treated EC. DDAVP-conditioned EC supernatant contained vWF and significantly increased platelet deposition on collagen. Platelets from patients with clinically suspected platelet dysfunction undergoing aortic valve replacement exhibited decreased platelet deposition on collagen surfaces. In summary, our data confirm that DDAVP can induce release of platelet adhesion promoting factors from EC, which is most likely vWF. DDAVP has no direct effect on platelets. Blood samples from DDAVP-treated patients do not exhibit significantly augmented platelet deposition on collagen ex vivo. This influence of released promoting factors might cause an increase of undesirable interactions of platelets with EC.
- Platelets.Platelets.2014;25(1):8-15. doi: 10.3109/09537104.2013.767442. Epub 2013 Mar 27.
- Platelet dysfunction can cause clinically relevant bleeding. Treatment with DDAVP is advocated for this condition. DDAVP increases von Willebrand factor (VWF) on endothelial cells (ECs) and in plasma. VWF could facilitate platelet deposition on subendothelial collagen. VWF also facilitates platelet/
- PMID 23534885
- Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling.
- Vaiyapuri S, Ali MS, Moraes LA, Sage T, Lewis KR, Jones CI, Gibbins JM.Author information From the Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom.AbstractOBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature. In this study, the effects of tangeretin, a dietary flavonoid, were explored on platelet function, signaling, and hemostasis.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Dec;33(12):2740-9. doi: 10.1161/ATVBAHA.113.301988. Epub 2013 Oct 17.
- OBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature. In this study, the effects of tangeretin, a dietary flavonoid, were explored on platelet function, signaling, and hemostasis.APPROACH AND RE
- PMID 24135020
Japanese Journal
- Smoking-Induced Alterations in Platelet Membrane Fluidity and Na+/K+-ATPase Activity in Chronic Cigarette Smokers
- , , ,
- Journal of Atherosclerosis and Thrombosis 17(6), 619-627, 2010
- … Platelet adhesiveness and aggregation increases as a result of smoking. … Cigarette smoking modifies haemostatic parameters via thrombosis with a consequently higher rate of cardiovascular events, but smoking-induced alterations of platelet membrane fluidity and other changes have not been studied.<BR>Methods: Thirty experimental and control subjects (mean age 35±8) were selected for the study. …
- NAID 130004845322
- Platelet and Cholesterol Responses Caused by Oral Administration ofGinseng Extract in 66% Hepatectomized Rats
- Xing Cui,Takeo Sakaguchi,Masahiro Ohtake
- Acta medica et biologica 47(1), 15-19, 1999-03
- … Platelet counts and serum cholesterol levels in the blood were examined after oral administration of ginseng extract (GE) to 66% hepatectomized rats. … A significant decrease in the platelet count (PC) and adhesiveness (PA) was obtained 3 days after hepatectomy when GE 125 mg/kg/day was administered, and the PA reduction was dose dependent in the range of 0-250 mg/kg/day. …
- NAID 110004461676
- 笠原 薫,高橋 徹,浜本 文恵,林 敏昭,安達 正晃,奥田 博介,佐藤 修司,鈴木 拓,日野田 裕治,今井 浩三
- 臨床血液 39(4), 308-313, 1998-04-30
- 症例は19歳男性,macrothrombocytopeniaの精査の為当科に紹介となった。血小板数は73,000/μlで巨大血小板が末梢血塗抹標本で認められた。4年前より重症のアトピー性皮膚炎に罹患している以外は出血傾向もなく健康であった。9歳時Fallot四徴症のためシャント手術を受けた際,初めて血小板減少を指摘されたというが,とくに合併症も起きなかった。血小板凝集能はADP, epinephr …
- NAID 10005900538
Related Links
- Platelet Adhesiveness information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Platelet Adhesiveness Description of Platelet Adhesiveness Platelet ...
- Platelet Adhesiveness. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Related Pictures
![Platelet adhesiveness](https://1mg.info/0/8/n/2908.jpg)
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![MBBS Medicine (Humanity First): Normal](https://1mg.info/0/8/n/2911.jpg)
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★リンクテーブル★
[★]
- 英
- platelet adhesiveness, platelet adhesion
- 関
- 血小板粘着性、血小板粘着、血小板粘着能検査
[★]
- 英
- platelet adhesiveness
- 関
- 血小板粘着能
[★]
- 関
- adherence、adherent、adhesive、adhesive property、cohesive、cohesiveness、stickiness、sticky