血小板粘着能、血小板粘着性

WordNet

the property of sticking together (as of glue and wood) or the joining of surfaces of different composition; "the mutual adhesiveness of cells"; "a heated hydraulic press was required for adhesion" (同)adhesion, adherence, bond
tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/08 18:41:48」(JST)

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1. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
2. 血小板生物学 platelet biology
3. 尿毒症における血小板機能不全 platelet dysfunction in uremia
4. 手術室で使用される局所止血剤および組織接着剤の概要 overview of topical hemostatic agents and tissues adhesives used in the operating room
5. 冠動脈疾患における血小板の役割 the role of platelets in coronary heart disease

English Journal

Pentoxifylline regulates the cellular adhesion and its allied receptors to extracellular matrix components in breast cancer cells.

Goel PN1, Gude RP2.Author information 1Gude Lab, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410210, India. Electronic address: peeyushgoel29@gmail.com.2Gude Lab, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410210, India. Electronic address: rajivgude@yahoo.in.AbstractPentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Being an inhibitor of platelet aggregation, it can thus reduce the adhesiveness of cancer cells prolonging their circulation time. This delay in forming secondary tumours makes them more prone to immunological surveillance. Recently, we have evaluated its anti-metastatic efficacy against breast cancer, using MDA-MB-231 model system. In view of this, we had ascertained the effect of PTX on adhesion of MDA-MB-231 cells to extracellular matrix components (ECM) and its allied receptors such as the integrins. PTX affected adhesion of breast cancer cells to matrigel, collagen type IV, fibronectin and laminin in a dose dependent manner. Further, PTX showed a differential effect on integrin expression profile. The experimental metastasis model using NOD-SCID mice showed lesser tumour island formation when treated with PTX compared to the control. These findings further substantiate the anti-adhesive potential of PTX in breast cancer and warrant further insights into the functional regulation.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.Biomed Pharmacother.2014 Feb;68(1):93-9. doi: 10.1016/j.biopha.2013.09.002. Epub 2013 Oct 8.
Pentoxifylline (PTX) is a methylxanthine derivative that improves blood flow by decreasing its viscosity. Being an inhibitor of platelet aggregation, it can thus reduce the adhesiveness of cancer cells prolonging their circulation time. This delay in forming secondary tumours makes them more prone t
PMID 24269001

Desmopressin (DDAVP) improves recruitment of activated platelets to collagen but simultaneously increases platelet endothelial interactions in vitro.

Calmer S, Ferkau A, Larmann J, Johanning K, Czaja E, Hagl C, Echtermeyer F, Goudeva L, Heuft HG, Theilmeier G.Author information Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School , Hannover , Germany.AbstractPlatelet dysfunction can cause clinically relevant bleeding. Treatment with DDAVP is advocated for this condition. DDAVP increases von Willebrand factor (VWF) on endothelial cells (ECs) and in plasma. VWF could facilitate platelet deposition on subendothelial collagen. VWF also facilitates platelet/EC interactions. Therefore DDAVP could precipitate thromboembolic events. We used a flow chamber model to study in vitro and ex vivo if DDAVP alters recruitment of platelets to EC and collagen. Resting or TRAP-activated platelets and EC were treated individually or simultaneously with 0.4 ng/ml DDAVP. Fluorophor-labeled platelets (10(6)/ml) were resuspended in reconstituted blood and superfused across EC and collagen in an in vitro flow chamber model at arterial shear (320 s(-1)). Adhesion of platelets to the respective surface was recorded fluorescence microscopically and platelet covered area was assessed. TRAP significantly induced adhesiveness of platelets for collagen and EC. DDAVP pretreatment of platelets did not affect adhesiveness of resting or TRAP-activated platelets for collagen or EC. Adhesiveness of resting but not TRAP-activated platelets was induced on DDAVP-treated EC. DDAVP-conditioned EC supernatant contained vWF and significantly increased platelet deposition on collagen. Platelets from patients with clinically suspected platelet dysfunction undergoing aortic valve replacement exhibited decreased platelet deposition on collagen surfaces. In summary, our data confirm that DDAVP can induce release of platelet adhesion promoting factors from EC, which is most likely vWF. DDAVP has no direct effect on platelets. Blood samples from DDAVP-treated patients do not exhibit significantly augmented platelet deposition on collagen ex vivo. This influence of released promoting factors might cause an increase of undesirable interactions of platelets with EC.
Platelets.Platelets.2014;25(1):8-15. doi: 10.3109/09537104.2013.767442. Epub 2013 Mar 27.
Platelet dysfunction can cause clinically relevant bleeding. Treatment with DDAVP is advocated for this condition. DDAVP increases von Willebrand factor (VWF) on endothelial cells (ECs) and in plasma. VWF could facilitate platelet deposition on subendothelial collagen. VWF also facilitates platelet/
PMID 23534885

Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling.

Vaiyapuri S, Ali MS, Moraes LA, Sage T, Lewis KR, Jones CI, Gibbins JM.Author information From the Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom.AbstractOBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature. In this study, the effects of tangeretin, a dietary flavonoid, were explored on platelet function, signaling, and hemostasis.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Dec;33(12):2740-9. doi: 10.1161/ATVBAHA.113.301988. Epub 2013 Oct 17.
OBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature. In this study, the effects of tangeretin, a dietary flavonoid, were explored on platelet function, signaling, and hemostasis.APPROACH AND RE
PMID 24135020

Japanese Journal

Smoking-Induced Alterations in Platelet Membrane Fluidity and Na+/K+-ATPase Activity in Chronic Cigarette Smokers

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Journal of Atherosclerosis and Thrombosis 17(6), 619-627, 2010
… Platelet adhesiveness and aggregation increases as a result of smoking. … Cigarette smoking modifies haemostatic parameters via thrombosis with a consequently higher rate of cardiovascular events, but smoking-induced alterations of platelet membrane fluidity and other changes have not been studied.<BR>Methods: Thirty experimental and control subjects (mean age 35±8) were selected for the study. …
NAID 130004845322

Platelet and Cholesterol Responses Caused by Oral Administration ofGinseng Extract in 66% Hepatectomized Rats

Xing Cui,Takeo Sakaguchi,Masahiro Ohtake
Acta medica et biologica 47(1), 15-19, 1999-03
… Platelet counts and serum cholesterol levels in the blood were examined after oral administration of ginseng extract (GE) to 66% hepatectomized rats. … A significant decrease in the platelet count (PC) and adhesiveness (PA) was obtained 3 days after hepatectomy when GE 125 mg/kg/day was administered, and the PA reduction was dose dependent in the range of 0-250 mg/kg/day. …
NAID 110004461676

遺伝性macrothrombocytopenia

笠原薫,高橋徹,浜本文恵,林敏昭,安達正晃,奥田博介,佐藤修司,鈴木拓,日野田裕治,今井浩三
臨床血液 39(4), 308-313, 1998-04-30
症例は19歳男性，macrothrombocytopeniaの精査の為当科に紹介となった。血小板数は73,000/μlで巨大血小板が末梢血塗抹標本で認められた。4年前より重症のアトピー性皮膚炎に罹患している以外は出血傾向もなく健康であった。9歳時Fallot四徴症のためシャント手術を受けた際，初めて血小板減少を指摘されたというが，とくに合併症も起きなかった。血小板凝集能はADP, epinephr …
NAID 10005900538